4′-[2-Butyl-4-chloro-5-(hydroxyiminomethyl)-1H-imidazol-3-ylmethyl]biphenyl-2-carbonitrile

Abstract

Key indicatorsSingle-crystal X-ray study T = 173 K Mean (C-C) = 0.003 Å Disorder in main residue R factor = 0.043 wR factor = 0.105 Data-to-parameter ratio = 13.8For details of how these key indicators were automatically derived from the article, seePerspective view of the title compound, with the atom numbering; displacement ellipsoids are drawn at the 50% probability level. The minor occupancy disordered atoms are shown with open bonds.

4'-(2-Butyl-4-chloro-5-formylimidazol-1-ylmethyl)biphenyl-2-carbonitrile

“…The title compound is used as a key intermediate for the synthesis of the antihypertensive drug losartan (Griffiths et al, 1999). In a continuation of our work on derivatives of imidazole (Yathirajan et al, 2005), and in order to establish the conformation of the title compound, the crystal structure determination was carried out.…”