3T sodium MR imaging in Alzheimer’s disease shows stage-dependent sodium increase influenced by age and local brain volume

Haeger, Alexa; Boumezbeur, Fawzi; Bottlaender, Michel; Rabrait-Lerman, Cécile; Lagarde, Julien; Mirzazade, Shahram; Krahe, Janna; Hohenfeld, Christian; Sarazin, Marie; Schulz, Jörg B.; Romanzetti, Sandro; Reetz, Kathrin

doi:10.1016/j.nicl.2022.103274

Cited by 1 publication

(8 citation statements)

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“…The mean sodium concentration in vitreous humor of AGRdm (145 mmol/L) was used as internal reference to scale all sodium reconstructions from arbitrary units to mmol/L. In the absence of external sodium concentration calibration standards, sodium concentration ratios between cortical GM and WM, and between cortical GM and a brainstem ROI eroded by 4 mm were also calculated, similar to the relative regional sodium quantification proposed in Reference 7.…”

Section: Methodsmentioning

confidence: 99%

“…3. "Anatomically guided" reconstruction of the combined first and second echo dataset including joint signal decay estimation and modeling (AGRdm) by solving equation ( 9) using the structural dTV prior * and a mono-exponential for signal decay during readout in (7) for u and r.…”

Section: Simulation Experimentsmentioning

confidence: 99%

“…Changes in tissue sodium concentration have been shown to provide physiologically relevant information for challenging brain pathologies such such as brain tumors, 1,2 stroke, 3,4 and Alzheimer's disease. [5][6][7] For an in-depth overview on the state-of-the-art of in vivo MR sodium imaging techniques and applications, we refer to the recent reviews by Madelin, 8 Sha, 9 Thulborn 10 and Hagiwara. 11 Despite its unique potential for providing non-invasive and physiologically relevant information, the development and clinical acceptance of sodium MRI has been hampered compared to proton MRI, owing to the unique data acquisition challenges posed by the NMR properties of the 23 Na nucleus, namely:…”

Section: Introductionmentioning

confidence: 99%

“…Sodium‐23 ( 23 Na) is the second most abundant MR‐active nucleus in the human body and plays a crucial role in ion homeostasis and cell viability. Changes in tissue sodium concentration have been shown to provide physiologically relevant information for challenging brain pathologies such such as brain tumors, 1,2 stroke, 3,4 and Alzheimer's disease 5–7 . For an in‐depth overview on the state‐of‐the‐art of in vivo MR sodium imaging techniques and applications, we refer to the recent reviews by Madelin, 8 Sha, 9 Thulborn 10 and Hagiwara 11 .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the images that are commonly obtained, suffer from spatial blurring beyond that corresponding to the nominal spatial resolution of the acquired spatial frequency values (i.e.,

1/2{k}_{\mathrm{max}}

) due to the fast decay of the signal during readout. As discussed in References 7 and 12, a direct consequence of the rather low resolution of sodium images are severe partial volume effects (PVEs) that make accurate quantification of local sodium concentration difficult. This is especially the case, when changes in local sodium concentration in the brain are accompanied by atrophy, necessitating advanced methods for partial volume correction.…”

Section: Introductionmentioning

confidence: 99%

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Resolution enhancement, noise suppression, and joint T2* decay estimation in dual‐echo sodium‐23 MR imaging using anatomically guided reconstruction

Schramm,

Filipovic,

Qian

et al. 2023

Magnetic Resonance in Med

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PurposeSodium MRI is challenging because of the low tissue concentration of the 23Na nucleus and its extremely fast biexponential transverse relaxation rate. In this article, we present an iterative reconstruction framework using dual‐echo 23Na data and exploiting anatomical prior information (AGR) from high‐resolution, low‐noise, 1H MR images. This framework enables the estimation and modeling of the spatially varying signal decay due to transverse relaxation during readout (AGRdm), which leads to images of better resolution and reduced noise resulting in improved quantification of the reconstructed 23Na images.MethodsThe proposed framework was evaluated using reconstructions of 30 noise realizations of realistic simulations of dual echo twisted projection imaging (TPI) 23Na data. Moreover, three dual echo 23Na TPI brain datasets of healthy controls acquired on a 3T Siemens Prisma system were reconstructed using conventional reconstruction, AGR and AGRdm.ResultsOur simulations show that compared to conventional reconstructions, AGR and AGRdm show improved bias‐noise characteristics in several regions of the brain. Moreover, AGR and AGRdm images show more anatomical detail and less noise in the reconstructions of the experimental data sets. Compared to AGR and the conventional reconstruction, AGRdm shows higher contrast in the sodium concentration ratio between gray and white matter and between gray matter and the brain stem.ConclusionAGR and AGRdm generate 23Na images with high resolution, high levels of anatomical detail, and low levels of noise, potentially enabling high‐quality 23Na MR imaging at 3T.

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Section: Methodsmentioning

confidence: 99%

Section: Simulation Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Moreover, the images that are commonly obtained, suffer from spatial blurring beyond that corresponding to the nominal spatial resolution of the acquired spatial frequency values (i.e.,