Abstract:The aim of this study was to develop a fast releasing oral polymeric thin film, prepared by solvent casting method, with good mechanical properties, instant disintegration and dissolution. Diphenhydramine hydrochloride, an antihistamine drug belonging to BCS class I was used for oral thin film preparation. The formulations from the preliminary trial were analyzed which was applied to optimize the type of polymers (Gelatin and HPMC E15), concentration of polymers, plasticizer (Glycerol, Propylene Glycol, PEG 40… Show more
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