Section 3: Production and Compounding 2018
DOI: 10.1136/ejhpharm-2018-eahpconf.57
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3PC-005 A new packaging of hypertonic solution to overcome an unavailable formulation in france

Abstract: BackgroundMannitol is considered the gold standard hyperosmolar agent to decrease intracranial pressure (ICP) after traumatic brain injury. However, solutions of mannitol may crystallise when exposed to low temperatures, for example at high altitude or during helicopter rescues. If crystals are observed, the container should be warmed, shaken and then cooled to body temperature before administration which is inappropriate in daily emergency practice. Several studies show that hypertonic saline solution (HTSS) … Show more

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