3MLCT excited states in Ru(II) complexes: Reactivity and related two-photon absorption applications in the near-infrared spectral range

Abstract

This short review provides a concise summary of the current state of research on the population by two-photon absorption of the triplet metal-to-ligand RésuméCette courte revue a pour objectif de fournir un état de l'art actuel, le plus concis et précis possible, concernant la recherche sur le phénomène de population par absorption à deux photons de l'état excité triplet à transfert de charge 3 MLTC au sein de complexes du ruthénium(II). Outre les applications de ce phénomène d'optique non linéaire à la limitation optique dans le proche infrarouge, des applications plus particulières en biologie (imagerie, dosage tant in vitro que in vivo du dioxygène et thérapie photodynamique ou PDT) sont ici décrites et envisagées. Pour citer cet article : G. Lemercier et al., C. R. Chimie 11 (2008).

Bioorthogonal Labeling, Bioimaging, and Photocytotoxicity Studies of Phosphorescent Ruthenium(II) Polypyridine Dibenzocyclooctyne Complexes

“…Two‐photon luminescence imaging is a useful technique in visualizing biomolecules in live cells because it provides larger penetration depth, lower photoinduced damage, reduced background autofluorescence, and higher image resolution 23. As the phosphorescence of many ruthenium(II) polypyridine complexes can be induced by two‐photon excitation at near‐infrared wavelengths,12b, 24 the nonlinear optical property will enable the visualization of Ac 4 ManNAz‐pretreated CHO‐K1 cells labeled by the DIBO complexes 1 a and 2 a using two‐photon excitation LSCM. The two‐photon absorption cross‐section ( σ TPA ) of complexes 1 a and 2 a measured at λ =750 nm (the excitation wavelength used in the two‐photon imaging studies, see below) were determined to be approximately 2.19 and 4.03 Goeppert–Mayer (GM) units (1 GM=10 −50 cm 4 s per photon), respectively.…”

Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics?

“…These results suggest that bimodal therapy potentially exerts a greater significant antitumor effect compared with one-modal therapy . Ru­(II) therapeutics for two-photon photodynamic therapy have been reported. , …”

Paramagnetic Oxygen as Contrast Agent for a Potential PDT Treatment MRI Monitoring

“…To evaluate the efficiency of a PS in PDT in a given medium, fluorescence study can be performed. Indeed, we evidenced that the luminescence of our new compounds (from the 3 MLCT emissive excited state) was then partially quenched (depending to the energy transfer efficiency) in the presence of 3 O 2 [21] . Actually, the triplet‐triplet energy transfer process efficiency can be evaluated with a Stern–Volmer quenching study and relation (evolution of the luminescence signal according to the quencher concentration).…”