3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance

Zhou, Fang; Zhang, Guang‐Xian; Rostami, Abdolmohamad

doi:10.1016/j.intimp.2010.11.005

Cited by 4 publications

(4 citation statements)

References 71 publications

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“…Coculture with NSCLC cells leads to the downregulation of the expression of CD40, CD80, CD86, and HLA-DR on human CD1c + DCs (Figures 4, 5). The biological features of NSCLCincubated DCs are similar to those of tolerogenic DCs, which have been previously used for DC-mediated immunotherapy to target autoimmune diseases (36)(37)(38)(39)(40)(41)(42)(43). Our results suggest that NSCLC cells may be able to induce tolerogenic DCs with the low expression of costimulatory molecules and MHCs so that DCmediated immune responses that are dependent on Signal 1-, 2-, and 3-associated molecules expressed on DCs are inhibited.…”

Section: Discussionsupporting

confidence: 65%

Non-small Cell Lung Cancer Cells Modulate the Development of Human CD1c+ Conventional Dendritic Cell Subsets Mediated by CD103 and CD205

et al. 2019

Front. Immunol.

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Advanced non-small cell lung cancer (NSCLC) leads to a high death rate in patients and is a major threat to human health. NSCLC induces an immune suppressive microenvironment and escapes from immune surveillance in vivo. At present, the molecular mechanisms of NSCLC immunopathogenesis and the immune suppressive microenvironment induced by NSCLC have not been fully elucidated. Here, we focus on the effect of NSCLC cells on the development and differentiation of human CD1c + conventional dendritic cell (DC) subsets mediated by CD205 and CD103. The peripheral blood mononuclear cells (PBMCs) were isolated from NSCLC patients and healthy donors. DCs were induced and cocultured with primary NSCLC cells or tumor cell line H1299. DCs without incubation with tumor cells are control. The protein expression of costimulatory molecules such as CD80 and CD86, HLA-DR, pro-/anti-inflammatory cytokines such as IL-10 and IL-12, and CD205 and CD103 on CD1c + DCs was detected by flow cytometry. Our data revealed two new subpopulations of human CD1c + DCs (CD1c + CD205 + CD103 + and CD1c + CD205 + CD103 − DC) in healthy donors and NSCLC patients. NSCLC cells modulate the development of the CD1c + CD205 + CD103 + DC and CD1c + CD205 + CD103 − DC subpopulations in vitro and ex vivo. NSCLC cells also suppress the expression of signal molecules such as CD40, CD80, CD86, and HLA-DR on CD1c + DCs. In addition, the production of pro-inflammatory cytokines, including IL-12 and IL-23, is downregulated by NSCLC cells; however, the secretion of anti-inflammatory cytokines, such as IL-10 and IL-27, by CD1c + DCs is upregulated by NSCLC cells. Our results suggest that NSCLC cells may induce immune tolerogenic DCs, which block DC-mediated anti-tumor immunity in NSCLC patients. Our data may be helpful in revealing new cellular mechanisms related to the induction of tolerogenic CD1c + DCs by NSCLCs and the development of an immune suppressive microenvironment that causes tumor cells to escape immune surveillance. Our results indicate a potential role for CD1c + DC subsets mediated by CD205 and CD103 in DC-mediated immunotherapy to target NSCLC in the future.

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Section: Discussionsupporting

confidence: 65%

Non-small Cell Lung Cancer Cells Modulate the Development of Human CD1c+ Conventional Dendritic Cell Subsets Mediated by CD103 and CD205

et al. 2019

Front. Immunol.

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“…Moreover, GITR is also expressed on surface of typical CD4 + T regs [13]. In addition, 3G11 is a marker for specific subsets of CD4 + T regs [14, 15, 20, 29]. It is unclear whether or not DCs regulate development of T regs through modulating expression of T reg -associated molecules.…”

Section: Discussionmentioning

confidence: 99%

“…Mouse MOG 35–55 peptide (MEVGWYRSPFSRVVHLYRNGK), a part of myelin oligodendrocyte glycoprotein (MOG), was provided by Invitrogen (Invitrogen, Carlsbad, CA, USA) [3, 4, 20–23]. …”

Section: Methodsmentioning

confidence: 99%

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LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4+ regulatory T cell subpopulations mediated by 3G11 and CD127

2016

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Intravenous transfer of LPS-treated bone marrow-derived dendritic cells blocks development of autoimmunity induced by CD4+ T cells in vivo. However, cellular mechanisms of dendritic cell-mediated immune tolerance have not yet been fully elucidated. Here, we report that there are two new subpopulations of CD4+CD25+FoxP3+GITR+ regulatory T cells (CD127+3G11+ and CD127+3G11− cells). LPS-treated dendritic cells facilitate development of CD4+CD127+3G11− regulatory T cells but inhibit that of CD4+CD127+3G11+ regulatory T cells. LPS-induced tolerogenic dendritic cells may cause immune tolerance through modulating balance of different subsets of CD4+ regulatory T cells mediated by CD127 and 3G11. Our results imply a new potential cellular mechanism of dendritic cell-mediated immune tolerance.

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The differentiation of new human CD303+ Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells

Zhong

et al. 2021

International Immunopharmacology

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3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance

Cited by 4 publications

References 71 publications

Non-small Cell Lung Cancer Cells Modulate the Development of Human CD1c+ Conventional Dendritic Cell Subsets Mediated by CD103 and CD205

Non-small Cell Lung Cancer Cells Modulate the Development of Human CD1c+ Conventional Dendritic Cell Subsets Mediated by CD103 and CD205

LPS-treated bone marrow-derived dendritic cells induce immune tolerance through modulating differentiation of CD4+ regulatory T cell subpopulations mediated by 3G11 and CD127

The differentiation of new human CD303+ Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells

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