3D Transcranial Ultrasound Localization Microscopy in the Rat Brain With a Multiplexed Matrix Probe

Chavignon, Arthur; Heiles, Baptiste; Hingot, Vincent; Orset, Cyrille; Vivien, Denis; Couture, Olivier

doi:10.1109/tbme.2021.3137265

Cited by 55 publications

(67 citation statements)

References 62 publications

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“…The 1024 channel system could be replaced by a single 256 channels system combined with electronic multiplexors, as it was recently demonstrated on the rat brain. 22 This approach, however, requires longer acquisition times and more importantly induces a significant loss of the temporal resolution. In this last study, 22 the use of 4:1 multiplexors reduced the volume rate by ten times.…”

Section: Discussionmentioning

confidence: 99%

“… 22 This approach, however, requires longer acquisition times and more importantly induces a significant loss of the temporal resolution. In this last study, 22 the use of 4:1 multiplexors reduced the volume rate by ten times. Such a strong imaging rate reduction affects the quality of velocity estimates in particular in large vessels.…”

Section: Discussionmentioning

confidence: 99%

“…2D velocity estimates can also be significantly underestimated when the vessels are not perfectly aligned to the 2D slice. Several approaches have been proposed to extend ULM to 3D including 1.5 D arrays, 20 fully addressed 2D matrix transducers, 21 multiplexed 2D arrays, 22 sparse 2D arrays, 23 hemispherical arrays 24 and row-column addressed probes. 25 We introduced a few years ago 3D ultrafast imaging using matrix transducers 26 and we recently demonstrated 3D ULM in phantoms.…”

Section: Introductionmentioning

confidence: 99%

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In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy

et al. 2022

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“…3DULM was extensively detailed in our previous paper 30 including all specifications on the volumetric ultrasound sequence, the transcranial brain imaging on rat, and the ULM post-processing. Briefly, volumes were acquired on an ultrafast research scanner Vantage 256 (Verasonics, Kirkland, USA) with a 32 × 32 ultrasonic matrix probe (central frequency 7.8 MHz, 300 µm pitch).…”

Section: Methodsmentioning

confidence: 99%

“…The elevation projection was solved with the emergence of volumetric imaging by combining thousands of transducers for 3DULM 26 – 29 . The system reaches a large field of view, an unbiased velocity estimation, and a quasi-isotropic resolution in-depth even though the intact skull bone 30 .…”

Section: Introductionmentioning

confidence: 99%

3D transcranial ultrasound localization microscopy for discrimination between ischemic and hemorrhagic stroke in early phase

Chavignon

Hingot

Orset

et al. 2022

Sci Rep

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Early diagnosis is a critical part of the emergency care of cerebral hemorrhages and ischemia. A rapid and accurate diagnosis of strokes reduces the delays to appropriate treatments and a better functional recovery. Currently, CTscan and MRI are the gold standards with constraints of accessibility, availability, and possibly some contraindications. The development of Ultrasound Localization Microscopy (ULM) has enabled new perspectives to conventional transcranial ultrasound imaging with increased sensitivity, penetration depth, and resolution. The possibility of volumetric imaging has increased the field-of-view and provided a more precise description of the microvascularisation. In this study, rats (n = 9) were subjected to thromboembolic ischemic stroke or intracerebral hemorrhages prior to volumetric ULM at the early phases after onsets. Although the volumetric ULM performed in the early phase of ischemic stroke revealed a large hypoperfused area in the cortical area of the occluded artery, it showed a more diffused hypoperfusion in the hemorrhagic model. Respective computations of a Microvascular Diffusion Index highlighted different patterns of perfusion loss during the first 24 h of these two strokes’ subtypes. Our study provides the first proof that this methodology should allow early discrimination between ischemic and hemorrhagic stroke with a potential toward diagnosis and monitoring in clinic.

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Evaluation of tumor microvasculature with 3D ultrasound localization microscopy based on 2D matrix array

Zhang,

Lei,

et al. 2024

Eur Radiol

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3D Transcranial Ultrasound Localization Microscopy in the Rat Brain With a Multiplexed Matrix Probe

Cited by 55 publications

References 62 publications

In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy

In vivo whole brain microvascular imaging in mice using transcranial 3D Ultrasound Localization Microscopy

3D transcranial ultrasound localization microscopy for discrimination between ischemic and hemorrhagic stroke in early phase

Evaluation of tumor microvasculature with 3D ultrasound localization microscopy based on 2D matrix array

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