3D titanium implant for orbital reconstruction after maxillectomy

Clerc, N.; Baudouin, Robin; Carlevan, M.; Khoueir, Nadim; Vérillaud, Benjamin; Herman, Philippe

doi:10.1016/j.bjps.2019.11.014

Cited by 23 publications

(23 citation statements)

References 23 publications

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“…Most previous studies focused on the calvaria 9 , 10 , orbital floor 11 – 13 , maxilla 14 , 15 , and alveolar bone 16 , where the function load was minimal. There are few reports on custom titanium implants for areas subjected to increased functional loads, such as the zygoma and mandible; however, this study proved that titanium patient-specific implants can function successfully in the zygoma and mandible.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction of maxillofacial bone defects using patient-specific long-lasting titanium implants

Lim

Choi

et al. 2022

Sci Rep

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The objective of this retrospective study is to verify the effectiveness and safety of patient-specific titanium implants on maxillofacial bones, with a long-term follow-up. Total 16 patients with various maxillofacial defects underwent reconstruction using patient-specific titanium implants. Titanium implants, manufactured by electron beam melting, selective laser sintering, or milling, were inserted into the maxilla, mandible, or zygoma. Long-term follow‐up (36.7 ± 20.1 months) was conducted after the surgery. Bone fusion of the titanium implant body, postoperative infection, implant malunion, functional results, patient satisfaction, subsidence, osteolysis around the implants, and complications were recorded and analyzed at the last follow-up. Of the 28 implants, only one failed to unite with the bone; therefore, revision surgery was performed. No osteolysis or subsidence around the titanium implants nor adverse events were observed; the mean VAS score for satisfaction was 9. All patients enrolled in this trial were esthetically and functionally satisfied with their surgical results, and fixation failure and esthetic dissatisfaction complications were well resolved. Patient-specific titanium showed satisfactory outcomes when used to treat various oral and maxillofacial defects. A 3D printed titanium implant can be effectively used in the reconstruction of the zygoma and mandible instead of autogenous bone without donor site morbidity.

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Section: Discussionmentioning

confidence: 99%

Reconstruction of maxillofacial bone defects using patient-specific long-lasting titanium implants

Lim

Choi

et al. 2022

Sci Rep

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“…Likewise, another cancer patient had his speech and eating habits restored after using 3DP prosthetics [ 123 ]. Herein, customised implants exhibiting high accuracy and showcasing complex structures can be designed and printed to act as alternatives to grafts in orbital reconstruction [ 124 , 125 ], craniofacial and maxillofacial implants [ 126 , 127 , 128 , 129 ], mandibular contouring and reconstruction [ 130 , 131 ] and nasal reconstruction [ 132 , 133 ].…”

Section: 3d Printing Of Nonbiological Medical Devicesmentioning

confidence: 99%

Three-Dimensional Printing for Cancer Applications: Research Landscape and Technologies

Ting

Youssef

et al. 2021

Pharmaceuticals

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As a variety of novel technologies, 3D printing has been considerably applied in the field of health care, including cancer treatment. With its fast prototyping nature, 3D printing could transform basic oncology discoveries to clinical use quickly, speed up and even revolutionise the whole drug discovery and development process. This literature review provides insight into the up-to-date applications of 3D printing on cancer research and treatment, from fundamental research and drug discovery to drug development and clinical applications. These include 3D printing of anticancer pharmaceutics, 3D-bioprinted cancer cell models and customised nonbiological medical devices. Finally, the challenges of 3D printing for cancer applications are elaborated, and the future of 3D-printed medical applications is envisioned.

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“…Three-dimensional (3D) printing, a novel technique in human reconstructive medicine, has advanced over the past three decades and has been applied in the production of patientspecific implants (11,12). Patient-specific implants have gained importance in treating maxillofacial defects owing to their precise adaptation, reduced surgical times, and better cosmesis (4,(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…In the veterinary literature, there are multiple clinical reports of reconstructive techniques without use of PSI (mini plates, bone grafts) for maxillofacial defects ( 10 , 11 , 13 , 15 – 18 ). Two case reports using 3D printing technique following tumor removal has been published ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

Case report: Reconstruction of a complex maxillofacial gunshot defect using a titanium patient-specific implant in a dog

et al. 2022

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This report describes the surgical reconstruction of large maxillofacial defect caused by a short-range gunshot injury in a dog using titanium patient-specific implant (PSI). A 3-year-old male Wolf Shepherd was admitted for a large right facial defect with right nasal cavity exposure caused by a gunshot injury. Radiographic examination revealed severe loss of the right maxillary, nasal, and incisive bones, multiple fractures of both left and right palatine bones, and a comminuted fracture of the right mandible. Initial surgical procedure included computed tomography (CT) imaging for three-dimensional (3D) implant design. Open wound management was maintained for 18 days until the fresh granulation tissue fully covered the wound bed. The implant was designed in a “hand grasping shape” to cover the defect, align multiple fractured palatine bones, and make a snap fit function. Multiple holes, including cortical screw holes, were added to the final design. The implant was printed on a titanium alloy. Surgical application of titanium PSI was performed 19 days after the primary surgery. A free sublingual mucosal graft was used to reconstruct the mucosal layer of the right nasal cavity. The mucosa was then covered with collagen membrane to strengthen the structure of the nasal cavity. Blunt dissection of the hard palate mucoperiosteum above the palatine process and palatine bones, soft tissue above the maxilla was performed, and the 3D printed titanium implant was fastened in a preplanned position. The facial soft tissue defect was reconstructed, and the titanium PSI was covered using an angularis oris cutaneous flap. Partial flap necrosis occurred in the rostral aspect, and the wound was managed to heal by a second intension. Flap dehiscence at the junction of the flap and hard palate mucoperiosteum occurred with exposure of the implant 2 days postoperatively. Multiple attempts to close the defect failed, and the owner wanted to stop treatment. Healthy granulated tissue was observed proximal to the implant. The defect no longer increased in size and did not show any noticeable complications related to the defect at 60 days after titanium PSI application, and the dog was discharged. Six months post-operatively, the dog remained active with great appetite, gained weight, and showed acceptable facial symmetry without enlargement of the implant exposure or any implant-related problems.

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3D titanium implant for orbital reconstruction after maxillectomy

Cited by 23 publications

References 23 publications

Reconstruction of maxillofacial bone defects using patient-specific long-lasting titanium implants

Reconstruction of maxillofacial bone defects using patient-specific long-lasting titanium implants

Three-Dimensional Printing for Cancer Applications: Research Landscape and Technologies

Case report: Reconstruction of a complex maxillofacial gunshot defect using a titanium patient-specific implant in a dog

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