3D static elastography at the micrometer scale using Full Field OCT

Nahas, Amir; Bauer, Morgane; Roux, Stéphane; Boccara, Albert‐Claude

doi:10.1364/boe.4.002138

Cited by 108 publications

(90 citation statements)

References 20 publications

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“…3). OCT contrast enhancement (prerequisite 3) has been accomplished by introducing polarization-sensitive OCT, [24][25][26][27][28] phasesensitive OCT, [29][30][31][32][33] optical coherence elastography, [34][35][36][37][38][39] spectroscopic low coherence interferometry, [40][41][42][43] elastic scattering spectroscopy, 31,[44][45][46] and nonlinear interferometric vibrational imaging (NIVI), as well as employing endogenous or exogenous contrast. [47][48][49][50][51][52] In this paper, a recently developed contrast improvement for OCT, named label-free optical angiography, is reviewed (cf.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

View full text Add to dashboard Cite

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“…General OCE techniques employ a loading device to induce tissue deformation and utilize OCT-based displacement-detection technique to monitor the dynamic response of the tissue [34][35][36]. The feasibilities of using OCE for three-dimensional elastic imaging [37,38], in vivo detection [39][40][41] and Young's modulus measurement [42][43][44] have been demonstrated on tissue-mimicking phantoms and different types of biological tissues, such as skin and soft-tissue tumor.…”

Section: Introductionmentioning

confidence: 99%

“…Alonso-Caneiro et al [45] and Dorronsoro et al [46] studied the dynamics of the cornea during an air puff, where the temporal characteristics of the corneal response are selected to qualitatively represent the mechanical properties of the whole cornea. With static loading of the cornea through a glass window, Ford et al [47] and Nahas et al [38] measured the amplitude of corneal deformation and utilized the mapping of the strain to provide depthresolved elastographic information of the cornea. Based on the detection of the elastic wave propagation inside the cornea, Li et al [48] and Manapuram et al [49] assessed the wave group velocity that can be used to quantitatively estimate the elasticity of the cornea.…”

Section: Introductionmentioning

confidence: 99%

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Wang

Larin

2014

Biomed. Opt. Express

152

129

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High-resolution elastographic assessment of the cornea can greatly assist clinical diagnosis and treatment of various ocular diseases. Here, we report on the first noncontact depth-resolved micro-scale optical coherence elastography of the cornea achieved using shear wave imaging optical coherence tomography (SWI-OCT) combined with the spectral analysis of the corneal Lamb wave propagation. This imaging method relies on a focused air-puff device to load the cornea with highly-localized lowpressure short-duration air stream and applies phase-resolved OCT detection to capture the low-amplitude deformation with nano-scale sensitivity. The SWI-OCT system is used here to image the corneal Lamb wave propagation with the frame rate the same as the OCT A-line acquisition speed. Based on the spectral analysis of the corneal temporal deformation profiles, the phase velocity of the Lamb wave is obtained at different depths for the major frequency components, which shows the depthwise distribution of the corneal stiffness related to its structural features. Our pilot experiments on ex vivo rabbit eyes demonstrate the feasibility of this method in depth-resolved micro-scale elastography of the cornea. The assessment of the Lamb wave dispersion is also presented, suggesting the potential for the quantitative measurement of corneal viscoelasticity. 3026-3031 (2007). 3. L. T. Nordan, "Keratoconus: diagnosis and treatment," Int. Ophthalmol. Clin. 37(1), 51-63 (1997). 4. C. Edmund, "Corneal elasticity and ocular rigidity in normal and keratoconic eyes," Acta Ophthalmol. (Copenh.) 66(2), 134-140 (1988 Biol. 93(1-3), 176-191 (2007). 17. G. Scarcelli and S. H. Yun, "Confocal Brillouin microscopy for three-dimensional mechanical imaging," Nat. ©2014 Optical Society of AmericaPhotonics 2(1), 39-43 (2008). 18. J. Schmitt, "OCT elastography: imaging microscopic deformation and strain of tissue," Opt. Express 3(6), 199-211 (1998). 19. G. Scarcelli and S. H. Yun, "In vivo Brillouin optical microscopy of the human eye," Opt. Express 20(8), 9197-9202 (2012). 20. G. Scarcelli, R. Pineda, and S. H. Yun, "Brillouin optical microscopy for corneal biomechanics," Invest.Ophthalmol. Vis. Sci. 53(1), 185-190 (2012). 21. G. Scarcelli, S. Kling, E. Quijano, R. Pineda, S. Marcos, and S. H. Yun, "Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus," Invest. Ophthalmol. Vis. Sci.

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“…Dealing with this issue can involve merely waiting for transients to decay (for up to several minutes [149]! ), or attempting to exploit the time dependence to extract more information.…”

Section: General Considerationsmentioning

confidence: 99%

“…In the meantime, other groups have been seeking to advance compression methods based on speckle tracking [46,149,166,167], largely borrowing from digital image correlation [21,22] methodologies, as described in Section 2. Such methods have also been developed for volumes, so-called digital volume correlation, which was first developed for X-ray computed tomography [168].…”

Section: Speckle Tracking In Quasi-static Compressionmentioning

confidence: 99%

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin

Sampson

2017

Biomed. Opt. Express

356

258

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Abstract:Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography -the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published in 2015, and more than 25 in 2016, OCE is growing fast, but still small compared to the companion fields of cell mechanics research methods, and medical elastography. In this review, we describe the early developments in OCE, and the factors that led to the current acceleration. Much of our attention is on the key recent advances, with a strong emphasis on future prospects, which are exceptionally bright.

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3D static elastography at the micrometer scale using Full Field OCT

Cited by 108 publications

References 20 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

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