“…However, there are challenges in the application of connectome-style analyses to dMRI [91] including anatomical variability of fiber tract terminations and cortical anatomy [8, 42, 96], spatial distortions [50], and reduced reproducibility due to the non-continuous nature of the matrix representation [56]. In contrast, white-matter-centric fiber analysis approaches can leverage information about the full course of a fiber tract, which is the anatomical basis for fiber tract definition [101], and empirical results indicate that white-matter-centric approaches benefit from low variability across subjects in terms of the WM parcellations that can be defined [109, 64, 19, 37].…”