3D-Scaffolds from Poly(3-hydroxybutyrate)Poly(ethylene glycol) Copolymer for Tissue Engineering

Бонарцев, А. П.; Zharkova, I. I.; Yakovlev, Sergey; Мышкина, В. Л.; Махина, Т. К.; Zernov, A. L.; Kudryashova, Kseniya S.; Feofanov, Аlexey V.; Akulina, E. A.; Ivanova, E. V.; Жуйков, В. А.; Andreeva, N. V.; Voinova, V. V.; Bessonov, I. V.; Kopitsyna, M. V.; Morozov, A. V.; Бонарцева, Г. А.; Шайтан, К. В.; Kirpichnikov, Mikhaǐl P.

doi:10.1166/jbt.2016.1414

Cited by 31 publications

(18 citation statements)

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“…[83] Bone tissue engineering: PHB-PEG scaffolds better than PHB for growth of bone marrow stromal cells. [84] Bone tissue engineering: human mesenchymal stromal cells (hMSCs) remained viable on PHB/nHA biocomposite scaffolds and proliferated continuously until reaching confluence. [85] Artificial blood vessels and heart valve: Mechanical properties of the PHBHHx films were improved significantly by blending with PPC without affecting the biocompatibility, similar results achieved with mcl PHA.…”

Section: Future Prospectivementioning

confidence: 99%

Polyhydroxyalkanoates (PHA) for therapeutic applications

Zhang

Shishatskaya

Volova

et al. 2018

Materials Science and Engineering: C

191

106

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As intracellular carbon and energy storage materials, polyhydroxyalkanoates (PHA) are a diverse biopolyesters synthesized by many bacteria. PHA have been produced in large quantity for various application research including medical implants for approximately 30years. Many studies demonstrated that PHA are promising implant materials due to their diverse and ascendant mechanical, biodegradable and tissue compatible properties. Importantly, common PHA biodegradation products including oligomers and monomers are also not toxic to the cells and tissues. Pharmaceutical applications of some PHA degradation products also have been reported. So far, no study has been reported to have any carcinogenesis result induced by any PHA or their biodegradation products. All results suggest that PHA could be developed into various bio-implant products.

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Section: Future Prospectivementioning

confidence: 99%

Polyhydroxyalkanoates (PHA) for therapeutic applications

Zhang

Shishatskaya

Volova

et al. 2018

Materials Science and Engineering: C

191

106

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“…This production method allows varying the physicochemical properties of polymers of this type over a wide range [12]. Because PHB has the ability to biodegrade and has high biocompatibility, it is widely used for biomedical applications in regenerative medicine and tissue engineering [13][14][15][16][17][18][19][20][21][22] and medicine forms [23][24][25][26]. It is able to create composites with synthetic polymers, inorganic materials [19,[27][28][29] and also as a new environmentally friendly material, including application as a material for the packaging industry [15,24,30,31].…”

Section: Introductionmentioning

confidence: 99%

“…The copolymer PHBV is more plastic, extensible, and resilient due to a decrease in the value of Young's modulus with an increase in the HV molar fraction in PHB-HV polymer chain Reference [32] The copolymerization of PHB with polyethylene glycol (PEG) increases water permeability and solubility due to the hygroscopicity of PEG. In addition, biocompatibility and hydrophilicity are improved compared to a homopolymer [15].…”

Section: Introductionmentioning

confidence: 99%

Comparative Structure-Property Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)s Films under Hydrolytic and Enzymatic Degradation: Finding a Transition Point in 3-Hydroxyvalerate Content

et al. 2020

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The hydrolytic and enzymatic degradation of polymer films of poly(3-hydroxybutyrate) (PHB) of different molecular mass and its copolymers with 3-hydroxyvalerate (PHBV) of different 3-hydroxyvalerate (3-HV) content and molecular mass, 3-hydroxy-4-methylvalerate (PHB4MV), and polyethylene glycol (PHBV-PEG) produced by the Azotobacter chroococcum 7B by controlled biosynthesis technique were studied under in vitro model conditions. The changes in the physicochemical properties of the polymers during their in vitro degradation in the pancreatic lipase solution and in phosphate-buffered saline for a long time (183 days) were investigated using different analytical techniques. A mathematical model was used to analyze the kinetics of hydrolytic degradation of poly(3-hydroxyaklannoate)s by not autocatalytic and autocatalytic hydrolysis mechanisms. It was also shown that the degree of crystallinity of some polymers changes differently during degradation in vitro. The total mass of the films decreased slightly up to 8–9% (for the high-molecular weight PHBV with the 3-HV content 17.6% and 9%), in contrast to the copolymer molecular mass, the decrease of which reached 80%. The contact angle for all copolymers after the enzymatic degradation decreased by an average value of 23% compared to 17% after the hydrolytic degradation. Young’s modulus increased up to 2-fold. It was shown that the effect of autocatalysis was observed during enzymatic degradation, while autocatalysis was not available during hydrolytic degradation. During hydrolytic and enzymatic degradation in vitro, it was found that PHBV, containing 5.7–5.9 mol.% 3-HV and having about 50% crystallinity degree, presents critical content, beyond which the structural and mechanical properties of the copolymer have essentially changed. The obtained results could be applicable to biomedical polymer systems and food packaging materials.

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“…PHB has a set of unique properties: high mechanical strength and thermal plasticity that allows to obtain a wide range of products due to easy processing, ability to form composites with synthetic polymers, inorganic materials and medicinal products, complete biodegradability to non‐toxic products, biocompatibility (including hemocompatibility) with human and animal tissues and organs and environmental safety, special diffusion properties that allows to produce devices and formulations for drugs sustained release . Therefore, PHB is widely used for biomedical applications in regenerative medicine and tissue engineering . However, PHB homopolymer has certain disadvantages as well: high hydrophobicity and crystallinity, long‐term biodegradation and low plasticity, which in some cases severely limits their use as bioengineered materials in medicine, for example for the manufacture of vessel grafts …”

Section: Introductionmentioning

confidence: 99%

“…[29] Therefore, PHB is widely used for biomedical applications in regenerative medicine and tissue engineering. [19][20][21][22][23][24][26][27][28][29][30] However, PHB homopolymer has certain disadvantages as well: high hydrophobicity and crystallinity, long-term biodegradation and low plasticity, which in some cases severely limits their use as bioengineered materials in medicine, for example for the manufacture of vessel grafts. [11,13,[31][32][33] It is generally accepted that biodegradation of PHB both in living systems and in environment occurs via enzymatic and non-enzymatic processes that take place simultaneously under natural conditions.…”

Section: Introductionmentioning

confidence: 99%

Effect of Poly(ethylene glycol) on the Ultrastructure and Physicochemical Properties of the Poly(3‐hydroxybutyrate)

Жуйков

Бонарцев

Zharkova

et al. 2017

Macromolecular Symposia

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Chemical conjugation or blending with poly(ethylene glycols) (PEGs) are established procedures to facilitate solubilisation of hydrophobic compounds. The techniques of bioPEGylation and blending with PEG were applied to poly(3‐hydroxybutyrate). In this paper we have examined the properties of copolymer of poly(3‐hydroxybutyrate‐co‐poly(ethylene glycol)) (PHB‐PEG) and composite material polyhydroxybutyrate with poly(ethylene glycol) (PHB + PEG) compared to homopolymer of poly(3‐hydroxybutyrate) (PHB). It was found that copolymer has significally different mechanical and thermophysical properties with respect to pure PHB: an increased crystallinity but a decreased Young's modulus and elongation at break. Moreover, the creation of the composite, and a copolymer of PHB with PEG results in a change in surface morphology of ultrathin films.

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3D-Scaffolds from Poly(3-hydroxybutyrate)Poly(ethylene glycol) Copolymer for Tissue Engineering

Cited by 31 publications

References 0 publications

Polyhydroxyalkanoates (PHA) for therapeutic applications

Polyhydroxyalkanoates (PHA) for therapeutic applications

Comparative Structure-Property Characterization of Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)s Films under Hydrolytic and Enzymatic Degradation: Finding a Transition Point in 3-Hydroxyvalerate Content

Effect of Poly(ethylene glycol) on the Ultrastructure and Physicochemical Properties of the Poly(3‐hydroxybutyrate)

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