3D pseudo-continuous arterial spin labeling-MRI (3D PCASL-MRI) in the differential diagnosis between glioblastomas and primary central nervous system lymphomas

Баталов, А И; Afandiev, R. M.; Захарова, Н. Е.; Pogosbekyan, E L; Shulgina, A A; Kobyakov, G L; Потапов, А А; Pronin, Igor

doi:10.1007/s00234-021-02888-4

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…Ранее была доказана возможность дифференцирования глиом высокой и низкой степени злокачественности при помощи рСASL-перфузии [1,5]. На основе перфузионных методов была выявлена возможность дифференцирования глио бластом и метастазов, глиобластом и лимфом, а также был исследован перитуморальный отек [6,22]…”

Section: методики мрт применяемые в оценке распространенности глиомunclassified

Magnetic Resonance Imaging in Studies of Perifocal Zone of Brain Gliomas (a Literature Review)

Zakharova,

Batalov,

Pogosbekyan

et al. 2023

jour

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This review provides insight into application of modern MRI modalities including diffusion kurtosis imaging in assessment of perifocal glioma zone. Differentiation of “pure” perifocal vasogenic edema from edema infiltrated by glioma cells, as well as identification of peritumoral intact (on conventional MRI) brain matter infiltration make it possible to determine glial tumor borders more accurately. Analysis of diffusion and perfusion quantitative MR data allow determining glioma borders in areas with unaltered blood-brain barrier. There is a growing possibility to develop a personalized navigation algorithm for surgical removal of the tumor, followed by the determination of an individual plan for radiation and chemotherapy, as well as prediction of disease outcomes.

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Section: методики мрт применяемые в оценке распространенности глиомunclassified

Magnetic Resonance Imaging in Studies of Perifocal Zone of Brain Gliomas (a Literature Review)

Zakharova,

Batalov,

Pogosbekyan

et al. 2023

jour

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“…Previously, pseudo-continuous arterial spin labeling (pCASL) showed the capability to differentiate high-and low-grade gliomas [9,10]. Perfusion methods were used to study peritumoral edema [11] as well as being successfully employed to differentiate glioblastomas and metastases or glioblastomas and lymphomas [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Perifocal Zone of Brain Gliomas: Application of Diffusion Kurtosis and Perfusion MRI Values for Tumor Invasion Border Determination

Захарова

Баталов

Pogosbekyan

et al. 2023

Cancers

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(1) Purpose: To determine the borders of malignant gliomas with diffusion kurtosis and perfusion MRI biomarkers. (2) Methods: In 50 high-grade glioma patients, diffusion kurtosis and pseudo-continuous arterial spin labeling (pCASL) cerebral blood flow (CBF) values were determined in contrast-enhancing area, in perifocal infiltrative edema zone, in the normal-appearing peritumoral white matter of the affected cerebral hemisphere, and in the unaffected contralateral hemisphere. Neuronavigation-guided biopsy was performed from all affected hemisphere regions. (3) Results: We showed significant differences between the DKI values in normal-appearing peritumoral white matter and unaffected contralateral hemisphere white matter. We also established significant (p < 0.05) correlations of DKI with Ki-67 labeling index and Bcl-2 expression activity in highly perfused enhancing tumor core and in perifocal infiltrative edema zone. CBF correlated with Ki-67 LI in highly perfused enhancing tumor core. One hundred percent of perifocal infiltrative edema tissue samples contained tumor cells. All glioblastoma samples expressed CD133. In the glioblastoma group, several normal-appearing white matter specimens were infiltrated by tumor cells and expressed CD133. (4) Conclusions: DKI parameters reveal changes in brain microstructure invisible on conventional MRI, e.g., possible infiltration of normal-appearing peritumoral white matter by glioma cells. Our results may be useful for plotting individual tumor invasion maps for brain glioma surgery or radiotherapy planning.

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“…These benefits include the fact that no contrast agent is necessary, the procedure is noninvasive, and repeatable scans that provide similar information can be obtained. To date, pCASL has been used in a variety of neurological and psychiatric diseases, including tumors, injuries, and ischemic diseases, [27][28][29] but few studies have investigated its utility in assessing microcirculation changes in patients with SLEs.…”

Section: Introductionmentioning

confidence: 99%

Cerebral Microstructural and Microvascular Changes in Non-Neuropsychiatric Systemic Lupus Erythematosus: A Study Using Diffusion Kurtosis Imaging and 3D Pseudo-Continuous Arterial Spin Labeling

Wang,

Huang,

Guo

et al. 2023

JIR

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The purpose of this study was to observe cerebral microstructure and microcirculation features, as well as changes in white matter (WM) and gray matter (GM) among patients with non-neuropsychiatric systemic lupus erythematosus (non-NPSLE). Methods: We compared 36 female patients with non-NPSLE and 20 age-and gender-matched healthy controls (HCs) who underwent 3.0T MRI imaging with diffusion kurtosis imaging (DKI) and 3D pseudo-continuous Arterial Spin Labeling (pCASL). Mean kurtosis (MK), mean kurtosis tensor (MKT), and cerebral blood flow (CBF) values were obtained from 25 brain regions, including WM and GM. We analyzed the correlation between imaging indicators and clinical data. Results: When compared with HCs, patients with non-NPSLE had reduced MK and MKT values in regional WM, deep GM, and the left frontal lobe cortical GM, and increased CBF in the right parietal lobe WM and right semioval center (SOC). The MK and MKT values were weakly correlated with CBF in some regions, including WM and GM. Complement 3 (C3) and Complement 4 (C4) showed a weak positive correlation with MK and MKT in some regions, including WM and deep GM, while platelet (PLT) was positively correlated with MKT in the left frontal lobe WM; dsDNA antibody was correlated negatively with MK in the right occipital lobe WM; and erythrocyte sedimentation rate (ESR) was correlated negatively with CBF in the left SOC. Conclusion: Our findings revealed the presence of brain microstructural and microvascular abnormalities in non-NPSLE patients, indicating microstructural damage in the cortical GM, which was less commonly reported. We found DKI and pCASL useful in detecting early brain lesions, and MK was a more sensitive and beneficial indicator.

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3D pseudo-continuous arterial spin labeling-MRI (3D PCASL-MRI) in the differential diagnosis between glioblastomas and primary central nervous system lymphomas

Cited by 6 publications

References 39 publications

Magnetic Resonance Imaging in Studies of Perifocal Zone of Brain Gliomas (a Literature Review)

Magnetic Resonance Imaging in Studies of Perifocal Zone of Brain Gliomas (a Literature Review)

Perifocal Zone of Brain Gliomas: Application of Diffusion Kurtosis and Perfusion MRI Values for Tumor Invasion Border Determination

Cerebral Microstructural and Microvascular Changes in Non-Neuropsychiatric Systemic Lupus Erythematosus: A Study Using Diffusion Kurtosis Imaging and 3D Pseudo-Continuous Arterial Spin Labeling

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