3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted microsyringe printing

Aita, Ilias El; Rahman, Jhinuk; Breitkreutz, Jörg; Quodbach, Julian

doi:10.1016/j.ejpb.2020.09.012

Cited by 70 publications

(39 citation statements)

References 22 publications

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“…With individually manufactured dosage forms, it is possible to adapt the dosage of the API and the release kinetics of the API to the patient. In this way, a wide range of therapeutic regimens can be covered and side effects reduced, as the most effective dose with the least adverse effects can be administered precisely [ 15 ]. In the future, the production of these individual batches could be realized by community pharmacies, hospitals and regional manufacturing hubs.…”

Section: Introductionmentioning

confidence: 99%

Predicting Drug Release from 3D Printed Oral Medicines Based on the Surface Area to Volume Ratio of Tablet Geometry

2021

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3D printing offers the advantage of being able to modify dosage form geometry, which can be exploited to modify release characteristics. In this study, we investigated the influence of the surface area to volume ratio (SA/V) to change and predict release profiles of 3D printed dosage forms. Geometries with varying SA/V and dosages were designed and printed, and drug dissolution was investigated. Three drug substances were used: pramipexole, levodopa (both BCS I) and praziquantel (BCS II). Two polymers were chosen as matrix formers: polyvinyl alcohol (water-soluble) and ethylene vinyl acetate (inert). Drug release was characterized using the mean dissolution time (MDT) and established equations that describe complete dissolution curves were applied. Predictions were validated with previously un-printed dosage forms. Based on an identified MDT-SA/V correlation, the MDT can be predicted with a deviation of ≤5 min for a given SA/V. Using correlations of fit parameters and SA/V, RMSEP values of 0.6–2.8% and 1.6–3.4% were obtained for the BCS I formulations and RMSEP values of 1.0–3.8% were obtained for the BCS II formulation, indicating accurate prediction over a wide range of dissolution profiles. With this approach, MDT and release profiles of dosage forms with a given SA/V can be precisely predicted without performing dissolution tests and vice versa, the required SA/V can be predicted for a desired release profile.

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Section: Introductionmentioning

confidence: 99%

Predicting Drug Release from 3D Printed Oral Medicines Based on the Surface Area to Volume Ratio of Tablet Geometry

2021

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“…It is expected that PAM will be used in the preparation of low cost, small batches of tailored, drug releasing tablets [99]. Indeed, PAM has been extensively used for the preparation of tablets [98][99][100]103,104] and chewable oral dosage forms [105]. In addition, drug releasing composite scaffolds for localized delivery [106], and a drug delivery patch [107] were developed as well.…”

Section: Pressure Assisted Microsyringe (Pam)mentioning

confidence: 99%

“…Tablets that showed immediate release (i.e. by disintegration) were prepared as well [100,103]. Drug dissolution appeared to depend on the amount of layers printed and by adjusting the surface area/volume ratio the drug release could be adjusted.…”

Section: Pressure Assisted Microsyringe (Pam)mentioning

confidence: 99%

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Polymeric drug delivery systems by additive manufacturing

Borandeh

Bochove

Teotia

et al. 2021

Advanced Drug Delivery Reviews

114

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Additive manufacturing (AM) is gaining interests in drug delivery applications, offering innovative opportunities for the design and development of systems with complex geometry and programmed controlled release profile. In addition, polymer-based drug delivery systems can improve drug safety, efficacy, patient compliance, and are the key materials in AM. Therefore, combining AM and polymers can be beneficial to overcome the existing limitations in the development of controlled release drug delivery systems. Considering these advantages, here we are focusing on the recent developments in the field of polymeric drug delivery systems prepared by AM. This review provides a comprehensive overview on a holistic polymer-AM perspective for drug delivery systems with discussion on the materials, properties, design and fabrication techniques and the mechanisms used to achieve a controlled release system. The current challenges and future perspectives for personalized medicine and clinical use of these systems are also briefly discussed.

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“…In the years following the approval of Spritam®, research supporting the use of 3DP to fabricate bespoke pharmaceutical formulations began at an exponential pace [11][12][13][14][15][16][17][18][19][20]. Although 3DP was initially employed to produce simple tablets, the academic 3DP community soon developed the expertise to produce complex structures, polypills, drug-loaded medical devices, and 4D designs [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Special patient populations were actively acknowledged in the movement, exemplified by the case of 3DP tablets incorporating Braille designs for the visually impaired [37,38].…”

Section: Moving 3dp Of Pharmaceuticals Beyond the Laboratory And Into The Clinicmentioning

confidence: 99%

Disrupting 3D printing of medicines with machine learning

Elbadawi

McCoubrey

Gavins

et al. 2021

Trends in Pharmacological Sciences

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3D-Printing with precise layer-wise dose adjustments for paediatric use via pressure-assisted microsyringe printing

Cited by 70 publications

References 22 publications

Predicting Drug Release from 3D Printed Oral Medicines Based on the Surface Area to Volume Ratio of Tablet Geometry

Predicting Drug Release from 3D Printed Oral Medicines Based on the Surface Area to Volume Ratio of Tablet Geometry

Polymeric drug delivery systems by additive manufacturing

Disrupting 3D printing of medicines with machine learning

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