3D printing technology in healthcare: applications, regulatory understanding, IP repository and clinical trial status

Gupta, Dipak Kumar; Ali, Mohd Humair; Ali, Akhter; Jain, Pooja; Anwer, Md. Khalid; Iqbal, Zeenat; Mirza, Mohd. Aamir

doi:10.1080/1061186x.2021.1935973

Cited by 43 publications

(15 citation statements)

References 108 publications

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“…In the current study, many scholars studied the application of 3D printing technology to assist fracture surgery and achieved good surgical effects, however, none of them studied in groups according to surgeons' experience [18,16,8,5,19]. Our study compared the operation effectiveness of inexperienced and experienced surgeons using 3D printing technology and routine CT images before operations with that of same inexperienced and experienced surgeons only using routine CT scan before operations.…”

Section: Discussionmentioning

confidence: 97%

“…In recent years, with the popularity of 3D printing technology, more and more surgical plans were made by orthopedic surgeons based on conventional CT images and 3D printed models. Surgeons have recently begun to apply 3D printing technology in almost all areas of orthopedic trauma surgery [4,5]. By creating speci c 3D printed anatomical models surgeons can better understand the anatomical structure details of patients' fractures, including trauma bone, surrounding soft tissue as well as normal areas.…”

Section: Introductionmentioning

confidence: 99%

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Comparing the Effectiveness of 3D Printing Technology in the Treatment of Clavicular Fracture between Surgeons with Different Experiences

Guo

Zhao

et al. 2021

Preprint

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Purpose To comparethe effectiveness of the three-dimensional (3D) printing technology in the treatment of clavicularfracturebetween experienced and inexperienced orthopedic surgeons. Methods A total of 80 patients with clavicle fracture (from February 2017 to May 2021)were enrolled in our study. Patients were divided randomly into four groups: group A: Patients underwent low-dose CT scan and 3D models were printed before surgeries performed by inexperienced surgeons; group B: Standard-dose CT were taken and 3D models were printed before surgeries performed by experienced surgeons; group C and D: Standard-dose CT were taken in both groups, and the operations were performed differently by inexperienced (group C) and experienced (group D) surgeons. Operation time, blood loss, length of incision and number of intraoperative fluoroscopy were recorded. Results No statistically significant differences were found in age, gender, fracture site and fracture type (P value: 0.23–0.88).Group A showed shorter incision length and less intraoperative fluoroscopy times than group C and D (P value < 0.05). There were no significant differences in blood loss volume, incision length and number of intraoperative time between group A and group B (P value range: 0.11–0.28). The operation time of group A was no longer than that of group C and D (P value range: 0.11 and 0.24). Conclusion The surgical effectiveness of inexperienced surgeons who applied 3D printing technology before clavicular fracture operation were better than those of both inexperienced and experienced surgeons did not use preoperative 3D printing technology.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Comparing the Effectiveness of 3D Printing Technology in the Treatment of Clavicular Fracture between Surgeons with Different Experiences

Guo

Zhao

et al. 2021

Preprint

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“…[ 266–268 ] In this second case, the absence of strong biological requirements has simplified their introduction in the medical practice, also from a regulatory perspective, which on the other hand is one of the strongest hindrances for implantable devices. [ 269 ] As noted by many authors, [ 4,9,41 ] the current absence of a dedicated regulation for FDM parts, from the mechanical characterization to the suitability of the final struct or device for medical use, is severely damaging both the developer evaluation of its products before the marketing stage and the final step of legal acceptance and implementation among the biomedical products.…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Grivet‐Brancot

Boffito

Ciardelli

2022

Macromolecular Bioscience

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In recent years, 3D printing techniques experience a growing interest in several sectors, including the biomedical one. Their main advantage resides in the possibility to obtain complex and personalized structures in a cost-effective way impossible to achieve with traditional production methods. This is especially true for fused deposition modeling (FDM), one of the most diffused 3D printing methods. The easy customization of the final products' geometry, composition, and physicochemical properties is particularly interesting for the increasingly personalized approach adopted in modern medicine. Thermoplastic polymers are the preferred choice for FDM applications, and a wide selection of biocompatible and biodegradable materials is available to this aim. Moreover, these polymers can also be easily modified before and after printing to better suit the body environment and the mechanical properties of biological tissues. This review focuses on the use of thermoplastic aliphatic polyesters for FDM applications in the biomedical field. In detail, the use of poly(𝝐-caprolactone), poly(lactic acid), poly(lactic-co-glycolic acid), poly(hydroxyalkanoate)s, thermoplastic poly(ester urethane)s, and their blends is thoroughly surveyed, with particular attention to their main features, applicability, and workability. The state-of-the-art is presented and current challenges in integrating the additive manufacturing technology in the medical practice are discussed.

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“…Further, prompt research should be carried out to develop novel biopolymer and multifunctional materials that should be adapted for biomedical device fabrication and be capable of performing numerous functions individually [ 96 ]. Additionally, it is crucial to develop completely automated low-cost, and economically viable bioprinters with an excellent resolution that will support the expansion of this technique [ 97 , 98 ].…”

Section: Future Perspectivementioning

confidence: 99%

Raw Materials, Technology, Healthcare Applications, Patent Repository and Clinical Trials on 4D Printing Technology: An Updated Review

Khan

Shabbir

et al. 2022

Pharmaceutics

Self Cite

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After the successful commercial exploitation of 3D printing technology, the advanced version of additive manufacturing, i.e., 4D printing, has been a new buzz in the technology-driven industries since 2013. It is a judicious combination of 3D printing technologies and smart materials (stimuli responsive), where time is the fourth dimension. Materials such as liquid crystal elastomer (LCE), shape memory polymers, alloys and composites exhibiting properties such as self–assembling and self-healing are used in the development/manufacturing of these products, which respond to external stimuli such as solvent, temperature, light, etc. The technologies being used are direct ink writing (DIW), fused filament fabrication (FFF), etc. It offers several advantages over 3D printing and has been exploited in different sectors such as healthcare, textiles, etc. Some remarkable applications of 4D printing technology in healthcare are self-adjusting stents, artificial muscle and drug delivery applications. Potential of applications call for further research into more responsive materials and technologies in this field. The given review is an attempt to collate all the information pertaining to techniques employed, raw materials, applications, clinical trials, recent patents and publications specific to healthcare products. The technology has also been evaluated in terms of regulatory perspectives. The data garnered is expected to make a strong contribution to the field of technology for human welfare and healthcare.

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3D printing technology in healthcare: applications, regulatory understanding, IP repository and clinical trial status

Cited by 43 publications

References 108 publications

Comparing the Effectiveness of 3D Printing Technology in the Treatment of Clavicular Fracture between Surgeons with Different Experiences

Comparing the Effectiveness of 3D Printing Technology in the Treatment of Clavicular Fracture between Surgeons with Different Experiences

Use of Polyesters in Fused Deposition Modeling for Biomedical Applications

Raw Materials, Technology, Healthcare Applications, Patent Repository and Clinical Trials on 4D Printing Technology: An Updated Review

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