3D printing technologies for 3D scaffold engineering

Do, Anh‐Vu; Smith, Rasheid; Acri, Timothy M.; Geary, Sean M.; Salem, Aliasger K.

doi:10.1016/b978-0-08-100979-6.00009-4

Cited by 30 publications

(26 citation statements)

References 136 publications

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“…Nonetheless, incorporating natural scaffolds or hydrogels such as collagen or fibrin gels into microfluidic systems can help ensure that the in vitro microtissues that are formed matches the mechanical properties of physiological tissue . Recently, 3‐D printing of biocompatible polymers has enabled an additive manufacturing approach for constructing in vitro biomimetic scaffolds . Successful integration of established microfabrication techniques with 3‐D printing should enable the biofabrication of increasingly more complex lymphatic microenvironments in vitro.…”

Section: Microfluidic Approaches For Studying Lymphatic Vasculaturementioning

confidence: 99%

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Application of microscale culture technologies for studying lymphatic vessel biology

2019

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Immense progress in microscale engineering technologies has significantly expanded the capabilities of in vitro cell culture systems for reconstituting physiological microenvironments that are mediated by biomolecular gradients, fluid transport, and mechanical forces. Here, we examine the innovative approaches based on microfabricated vessels for studying lymphatic biology. To help understand the necessary design requirements for microfluidic models, we first summarize lymphatic vessel structure and function. Next, we provide an overview of the molecular and biomechanical mediators of lymphatic vessel function. Then we discuss the past achievements and new opportunities for microfluidic culture models to a broad range of applications pertaining to lymphatic vessel physiology. We emphasize the unique attributes of microfluidic systems that enable the recapitulation of multiple physicochemical cues in vitro for studying lymphatic pathophysiology. Current challenges and future outlooks of microscale technology for studying lymphatics are also discussed. Collectively, we make the assertion that further progress in the development of microscale models will continue to enrich our mechanistic understanding of lymphatic biology and physiology to help realize the promise of the lymphatic vasculature as a therapeutic target for a broad spectrum of diseases.

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Section: Microfluidic Approaches For Studying Lymphatic Vasculaturementioning

confidence: 99%

“…153,154 Recently, 3-D printing of biocompatible polymers has enabled an additive manufacturing approach for constructing in vitro biomimetic scaffolds. 155 Successful integration of established microfabrication techniques with 3-D printing should enable the biofabrication of increasingly more complex lymphatic microenvironments in vitro.…”

Section: Limitationsmentioning

confidence: 99%

Application of microscale culture technologies for studying lymphatic vessel biology

2019

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“…Hence, significant research and development efforts in the field of tissue engineering have been made and have led to the creation of functional skin tissue substitutes . The design of three‐dimensional (3D) scaffolds with the biological characteristics and functions of the native extracellular matrix (ECM) is one of the most important challenges in tissue engineering …”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8] The design of threedimensional (3D) scaffolds with the biological characteristics and functions of the native extracellular matrix (ECM) is one of the most important challenges in tissue engineering. [9,10] To develop a clinical 3D construct, the performance of decellularized tissues as biological scaffolds were evaluated. [11,12] However, the application of decellularized allogeneic organs is limited due to the lack of donor organs.…”

Section: Introductionmentioning

confidence: 99%

Graphene functionalized decellularized scaffold promotes skin cell proliferation

et al. 2019

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An increasing number of new strategies for skin tissue engineering have been developed with the potential to mimic the biological properties of native tissue with a high degree of complexity, flexibility, and reproducibility. In this study, decellularized tissue (DT) was prepared from the bovine heart by using chemical treatments. However, the mechanical properties of the DT constructs were poorer than the extra cellular matrix of the skin tissue. To overcome this challenge, hybrid scaffolds of DT and graphene oxide (GO) were developed and the effects of the GO concentration on the morphology, pore size, porosity, mechanical strength, and water uptake capacity of the samples were evaluated. Moreover, the biocompatibility of hybrid scaffolds was studied by Live/Dead staining. The results show that a hybrid scaffold incorporating 3 % graphene oxide improved the mechanical strength and cell viability by ~25 % in comparison to the DT scaffolds. Cell viability results confirmed that the porous scaffolds could support cell adhesion, proliferation, and cell activity for 7 days. This study provides new insight into and opportunities for using graphene‐based materials to develop biomimetic constructs for clinical applications.

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“…To achieve personalized dosages with conventional methods, only the dose can be adjusted. With the assistance of computational design, a researcher can adjust the dose, customize the drug-release profiles by complex structure design, and combine multiple active pharmaceutical ingredients (APIs) into a single dose (25–28). In addition, AM is more efficient and economical by reducing the downstream process (29).…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems

Zhang

Feng

et al. 2018

AAPS PharmSciTech

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Inter-individual variability is always an issue when treating patients of different races, genders, ages, pharmacogenetics, and pharmacokinetic characteristics. However, the development of novel dosage forms is limited by the huge investments required for production line modifications and dosages diversity. Additive manufacturing (AM) or 3D printing can be a novel alternative solution for the development of controlled release dosages because it can produce personalized or unique dosage forms and more complex drug-release profiles. The primary objective of this manuscript is to review the 3D printing processes that have been used in the pharmaceutical area, including their general aspects, materials, and the operation of each AM technique. Advantages and shortcomings of the technologies are discussed with respect to practice and practical applications. Thus, this review will provide an overview and discussion on advanced pharmaceutical AM technologies, which can be used to produce unique controlled drug delivery systems and personalized dosages for the future of personalized medicine.

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3D printing technologies for 3D scaffold engineering

Cited by 30 publications

References 136 publications

Application of microscale culture technologies for studying lymphatic vessel biology

Application of microscale culture technologies for studying lymphatic vessel biology

Graphene functionalized decellularized scaffold promotes skin cell proliferation

Pharmaceutical Additive Manufacturing: a Novel Tool for Complex and Personalized Drug Delivery Systems

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