3D printing of robust and biocompatible poly(ethylene glycol)diacrylate/nano-hydroxyapatite composites <i>via</i> continuous liquid interface production

Deng, Xueyong; Huang, Bingxue; Hu, Rui; Chen, Liling; Tang, Yingying; Lu, Canhui; Chen, Zhenming; Zhang, Wei; Zhang, Ximu

doi:10.1039/d0tb02182b

Cited by 24 publications

(18 citation statements)

References 49 publications

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“…The second stage of degradation occurs with a mass loss of 55.72% and a maximum degradation temperature of 391 °C. This degradation event is related to PEGDA polymer chains [ 43 , 44 , 45 , 46 , 47 ]. On the other hand, Lap has a mass loss stage (8.1% mass loss) at a maximum temperature of 68 °C, related to the evaporation of water, which occurs up to 180 °C.…”

Section: Resultsmentioning

confidence: 99%

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Magalhães

Andrade

Bezerra

et al. 2022

JFB

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Herein, a nanocomposite hydrogel was produced using laponite and polyethylene-glycol diacrylate (PEGDA), with or without Irgacure (IG), for application in bone tissue regeneration. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier-Transform infrared spectroscopy (FTIR), and thermal analysis (TG/DTG). The XRD results showed that the crystallographic structure of laponite was preserved in the nanocomposite hydrogels after the incorporation of PEGDA and IG. The FTIR results indicated that PEGDA polymer chains were entangled on laponite in hydrogels. The TG/DTG found that the presence of laponite (Lap) improved the thermal stability of nanocomposite hydrogel. The toxicity tests by Artemia salina indicated that the nanocomposite hydrogels were not toxic, because the amount of live nauplii was 80.0%. In addition, in vivo tests demonstrated that the hydrogels had the ability to regenerate bone in a bone defect model of the tibiae of osteopenic rats. For the nanocomposite hydrogel (PEGDA + Lap nanocomposites + UV light), the formation of intramembranous bone in the soft callus was more intense in 66.7% of the animals. Thus, the results presented in this study evidence that nanocomposite hydrogels obtained from laponite and PEGDA have the potential for use in bone regeneration.

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Section: Resultsmentioning

confidence: 99%

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Magalhães

Andrade

Bezerra

et al. 2022

JFB

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“…Poly(ethylene glycol) diacrylate (PEGDA), a biocompatible acrylate monomer, was chosen for its ability to undergo free-radical polymerization and its common use for medical applications. 77–80 Irradiation was carried out on the B band of PS using LED@405 nm and LED@455 nm (Fig. 7 and S23†), but also on the Q band with LED@625 nm and LED@660 nm (Fig.…”

Section: Resultsmentioning

confidence: 99%

Bio-based porphyrins pyropheophorbide a and its Zn-complex as visible-light photosensitizers for free-radical photopolymerization

et al. 2022

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“…AA, PEGDA, and CNC were chosen as they have already been reported as biocompatible materials. − Moreover, the TPO PI was shown to not have any cytotoxic effect on human epithelial colorectal adenocarcinoma cells . However, to minimize the possible negative PI effects, a minimal concentration of TPO was used that enabled rapid curing under a short irradiation time.…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Cellulose Nanocrystal-Loaded Hydrogels through Rapid Fixation by Photopolymerization

et al. 2021

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New ink compositions for direct ink writing (DIW) printing of hydrogels, combining superior rheological properties of cellulose nanocrystals (CNCs) and a water-compatible photoinitiator, are presented. Rapid fixation was achieved by photopolymerization induced immediately after the printing of each layer by 365 nm light for 5 s, which overcame the common height limitation in DIW printing of hydrogels, and enabled the fabrication of objects with a high aspect ratio. CNCs imparted a unique rheological behavior, which was expressed by orders of magnitude difference in viscosity between low and high shear rates and in rapid high shear recovery, without compromising ink printability. Compared to the literature, the presented printing compositions enable the use of low photoinitiator concentrations at a very short build time, 6.25 s/mm, and are also curable by 405 nm light, which is favorable for maintaining viability in bioinks.

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3D printing of robust and biocompatible poly(ethylene glycol)diacrylate/nano-hydroxyapatite composites via continuous liquid interface production

Abstract: This work demonstrates the first successful attempt on CLIP 3D printing of n-HA nanocomposites, providing a feasible, cost-effective and patient-specific solution for future bone tissue engineering.

Cited by 24 publications

References 49 publications

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration

Bio-based porphyrins pyropheophorbide a and its Zn-complex as visible-light photosensitizers for free-radical photopolymerization

3D Printing of Cellulose Nanocrystal-Loaded Hydrogels through Rapid Fixation by Photopolymerization

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