3D Printing of Reservoir Devices for Oral Drug Delivery: From Concept to Functionality through Design Improvement for Enhanced Mucoadhesion

Abstract

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Micro and nanoscale technologies in oral drug delivery

“…However, more advanced microfabricated systems (3D printed or lithography enabled casting), have typically a complex engineering design and low-throughput manufacturing processes that result in high cost of fabrication [ 29 , 168 , 269 , 170 ]. For example, the current workflow for 3D printed drug delivery systems is multi-step (3D printing, drug loading, sealing, substrate release) and involves expensive equipment (3D printer, inkjet printer, spray coater) [ 270 ]. Recently, rapid and large-scale 3D printing was achieved using a mobile liquid interface that minimize heat buildup [ 271 ].…”

Disrupting 3D printing of medicines with machine learning

“…In the years following the approval of Spritam®, research supporting the use of 3DP to fabricate bespoke pharmaceutical formulations began at an exponential pace [11][12][13][14][15][16][17][18][19][20]. Although 3DP was initially employed to produce simple tablets, the academic 3DP community soon developed the expertise to produce complex structures, polypills, drug-loaded medical devices, and 4D designs [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Special patient populations were actively acknowledged in the movement, exemplified by the case of 3DP tablets incorporating Braille designs for the visually impaired [37,38].…”

Cubic Microcontainers Improve In Situ Colonic Mucoadhesion and Absorption of Amoxicillin in Rats

“…However, these microdevices were not investigated in situ or in vivo and the surface structures on these devices were remarkably smaller (60-160 nm) than the pillars on the surface of the microcontainers in the present study (41 µm in height and 35 µm in diameter). In a different study, the impact of larger and more complex surface structures was investigated ex vivo and these were found to have a large impact on the adhesive properties of the microdevices [39].…”

“…Previously, we have seen that the shape and surface texture of microdevices influence mucoadhesion ex vivo [22,39]. More specifically, triangular microcontainers previously resulted in improved mucoadhesion in parts of a small intestinal section compared to cylindrical microcontainers [22].…”