3D printing of pharmaceutical oral solid dosage forms by fused deposition: The enhancement of printability using plasticised HPMCAS

Oladeji, Simisola; Mohylyuk, Valentyn; Andrews, Gavin

doi:10.1016/j.ijpharm.2022.121553

Cited by 30 publications

(17 citation statements)

References 64 publications

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“…The crystalline 5-ASA drug exhibited a double melting peak that could be attributed to different crystal sizes [50]. The The results obtained for the raw materials agree with those of previous studies [13,30,49]. The DSC thermogram of the physical mixture was similar to that of HPMCAS-HG, the main component in the mixture.…”

Section: Differential Scanning Calorimetry (Dsc)supporting

confidence: 87%

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Shojaie,

Ferrero,

Caraballo

2023

Pharmaceutics

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Dual-nozzle fused deposition modeling (FDM) is a 3D printing technique that allows for the simultaneous printing of two polymeric filaments and the design of complex geometries. Hence, hybrid formulations and structurally different sections can be combined into the same dosage form to achieve customized drug release kinetics. The objective of this study was to develop a novel bicompartmental device by dual-nozzle FDM for colon-specific drug delivery. Hydroxypropylmethylcellulose acetate succinate (HPMCAS) and polyvinyl alcohol (PVA) were selected as matrix-forming polymers of the outer pH-dependent and the inner water-soluble compartments, respectively. 5-Aminosalicylic acid (5-ASA) was selected as the model drug. Drug-free HPMCAS and drug-loaded PVA filaments suitable for FDM were extruded, and their properties were assessed by thermal, X-ray diffraction, microscopy, and texture analysis techniques. 5-ASA (20% w/w) remained mostly crystalline in the PVA matrix. Filaments were successfully printed into bicompartmental devices combining an outer cylindrical compartment and an inner spiral-shaped compartment that communicates with the external media through an opening. Scanning electron microscopy and X-ray tomography analysis were performed to guarantee the quality of the 3D-printed devices. In vitro drug release tests demonstrated a pH-responsive biphasic release pattern: a slow and sustained release period (pH values of 1.2 and 6.8) controlled by drug diffusion followed by a faster drug release phase (pH 7.4) governed by polymer relaxation/erosion. Overall, this research demonstrates the feasibility of the dual-nozzle FDM technique to obtain an innovative 3D-printed bicompartmental device for targeting 5-ASA to the colon.

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Section: Differential Scanning Calorimetry (Dsc)supporting

confidence: 87%

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Shojaie,

Ferrero,

Caraballo

2023

Pharmaceutics

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“…Specifically, the simplicity and low cost of FDM 3DP has led to the general view that it may be the technology to be clinically adopted to produce personalized medicines. Enthusiasm towards FDM 3DP amongst pharmaceutical researchers has been demonstrated by its use to manufacture a range of drug delivery devices, including 3D printed tablets (Printlets) ( Bogdahn et al, 2021 ; Figueiredo et al, 2022 ; Isreb et al, 2019 ; Melocchi et al, 2021 ; Oladeji et al, 2022 ; Pereira et al, 2020 ; Shi et al, 2021 ; Tranová et al, 2022 ; Windolf et al, 2022 ), gastro-retentive tablets ( Zhao et al, 2022 ), microneedles ( Wu et al, 2021 ), and patient-specific devices ( Arany et al, 2021 ; Carlier et al, 2021 ; Eleftheriadis and Fatouros, 2021 ; Eleftheriadis et al, 2020 ; Haddow et al, 2021 ; Liang et al, 2018 ; Saviano et al, 2022 ). While interest in pharmaceutical 3DP continues to grow, with pharmaceutical companies such as Aprecia and Triastek investing in the technology, progress is arguably hampered by the empirical process of formulation development ( Elbadawi et al, 2021b ; Seoane-Viaño et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Accelerating 3D printing of pharmaceutical products using machine learning

Ong

Castro

Gaisford

et al. 2022

International Journal of Pharmaceutics: X

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“…It was allowed to determine that the printed samples have a good printed surface. However, due to the previously discussed shrinkage, a lower viscosity deposit, combined with the compensation system due to the total filling of the sample, overlaps the deposition lines and even making it difficult to visualize the deposition direction of all systems 18,62 . Thus, the behavior presented by the deposition may indicate a formation between the more compact interlayers and a more remarkable absence of voids commonly reproduced in the 3D printing in FDM process 10,18 …”

Section: Resultsmentioning

confidence: 99%

“…However, due to the previously discussed shrinkage, a lower viscosity deposit, combined with the compensation system due to the total filling of the sample, overlaps the deposition lines and even making it difficult to visualize the deposition direction of all systems. 18,62 Thus, the behavior presented by the deposition may indicate a formation between the more compact interlayers and a more remarkable absence of voids commonly reproduced in the 3D printing in FDM process. 10,18 The images also indicate that there was a good filler distribution in the polymer matrix due to the low presence of agglomerates on the surface, corroborating the previous optical micrographs (Figure 6), where the particle agglomerates are detected but well distributed.…”

Section: Scanning Electron Microscopymentioning

confidence: 87%

Development of biodegradable filaments based on agro‐industrial waste and evaluation of process parameters in final properties

da Silva Fortes,

de Abreu,

de Sousa Nascimento Junior

et al. 2023

Polymer Composites

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Additive manufacturing, which has become popular in recent years, is the process of joining materials through the deposition of layers to form parts based on data from a 3D model and fused deposition modeling. The search for biodegradable materials for the production of filaments for 3D printing is increasing and opening up possibilities for the development of new sustainable products, including the use of lignocellulosic waste in the formulation. Therefore, the present work aims to develop polymeric filaments based on polybutylene adipate terephthalate and low content (2.5 and 5 wt%) of peanut and soybean shells and evaluate their potential for 3D printing. The charges were characterized in terms of chemical composition. Tensile and dimensional variation tests were performed on samples manufactured from two different filling orientations: −45/45° and 0/90°. The printability of the filament was based on the manufacture of prototypes of agricultural tubes that were also characterized by thermogravimetry and their morphology through scanning electron and optical microscopy. Both natural residues significantly (p < 0.05) affected the sample dimensions and mechanical properties. However, the filling orientation difference was insignificant (p > 0.05). The filaments produced showed good processability, thermal and dimensional stability. The samples produced showed a satisfactory surface finish without exposing load agglomerates. These results demonstrate the feasibility of using lignocellulosic fillers, such as peanut and soybean shells, in additive manufacturing and indicate the possibility of producing parts with varied geometries.Highlights Use of lignocellulosic residues in biodegradable filaments. The filament produced with fillers of peanut and soybean shells showed good processability. Filament fracture depends on the raster angle. It was possible to produce tubes with good surface quality and mechanical properties.

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3D printing of pharmaceutical oral solid dosage forms by fused deposition: The enhancement of printability using plasticised HPMCAS

Cited by 30 publications

References 64 publications

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Development of 3D-Printed Bicompartmental Devices by Dual-Nozzle Fused Deposition Modeling (FDM) for Colon-Specific Drug Delivery

Accelerating 3D printing of pharmaceutical products using machine learning

Development of biodegradable filaments based on agro‐industrial waste and evaluation of process parameters in final properties

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