3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder

Tabriz, Atabak Ghanizadeh; Mithu, Md Sadeque; Antonijević, Milan D.; Vilain, Lilian; Derrar, Youri; Grau, Clara; Morales, Anaïs; Katsamenis, Orestis L.; Douroumis, Dennis

doi:10.1016/j.ijpharm.2022.122574

Cited by 13 publications

(6 citation statements)

References 23 publications

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“…In the past 7 years, we have shown that it is possible to set up a facility for the μCT imaging community, with successful completion and initiation of over 120 projects involving 125+ collaborators from 60 affiliations. This has resulted in 15 published manuscripts, 10 submitted/in preparation, over 35 conference proceedings, and over 25 research funding proposals 1 – 3 , 7 , 23 , 30 – 32 , 37 , 44 , 56 – 59 .…”

Section: Discussionmentioning

confidence: 99%

A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications

Katsamenis,

Basford,

Robinson

et al. 2023

Wellcome Open Res

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Background The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray microfocus computed tomography (μCT) -based technology. This article presents the outcomes of these endeavours and highlights the distinctive characteristics of a μCT facility tailored explicitly for 3D X-ray Histology, with a primary focus on applications in biomedical research and preclinical and clinical studies. Methods The UHS houses a unique 3D X-ray Histology (XRH) facility, offering a range of services to national and international clients. The facility employs specialised μCT equipment explicitly designed for histology applications, allowing whole-block XRH imaging of formalin-fixed and paraffin-embedded tissue specimens. It also enables correlative imaging by combining μCT imaging with other microscopy techniques, such as immunohistochemistry (IHC) and serial block-face scanning electron microscopy, as well as data visualisation, image quantification, and bespoke analysis. Results Over the past seven years, the XRH facility has successfully completed over 120 projects in collaboration with researchers from 60 affiliations, resulting in numerous published manuscripts and conference proceedings. The facility has streamlined the μCT imaging process, improving productivity and enabling efficient acquisition of 3D datasets. Discussion & Conclusions The 3D X-ray Histology (XRH) facility at UHS is a pioneering platform in the field of histology and biomedical imaging. To the best of our knowledge, it stands out as the world's first dedicated XRH facility, encompassing every aspect of the imaging process, from user support to data generation, analysis, training, archiving, and metadata generation. This article serves as a comprehensive guide for establishing similar XRH facilities, covering key aspects of facility setup and operation. Researchers and institutions interested in developing state-of-the-art histology and imaging facilities can utilise this resource to explore new frontiers in their research and discoveries.

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Section: Discussionmentioning

confidence: 99%

A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications

Katsamenis,

Basford,

Robinson

et al. 2023

Wellcome Open Res

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“…The first FDA-approved 3D printed medication Spritam ® specifically includes the orodispersible feature to address the swallowing difficulty (68). Furthermore, immediate, delayed, pulsatile, and prolonged release profiles can be achieved by choosing fitting materials and technologies (69)(70)(71)(72). Prolonged or delayed drug release would enable children to take their medication in a familiar setting in the morning or evening instead of relying on daycare (55).…”

Section: Personalization Options Of 3d Printed Medicationsmentioning

confidence: 99%

The potential of three-dimensional printing for pediatric oral solid dosage forms

Kreft,

Fanous,

Möckel

2024

Acta Pharmaceutica

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Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing accuracy and palatability. This paper explores the potential of 3D printing as a solution to address the challenges and provide tailored doses of medication for each pediatric patient. The technological overview of 3D printing is discussed, highlighting various 3D printing technologies and their suitability for pharmaceutical applications. Several individualization options with the potential to improve adherence are discussed, such as individualized dosage, custom release kinetics, tablet shape, and palatability. To integrate the preparation of 3D printed medication at the point of care, a decentralized manufacturing model is proposed. In this setup, pharmaceutical companies would routinely provide materials and instructions for 3D printing, while specialized compounding centers or hospital pharmacies perform the printing of medication. In addition, clinical opportunities of 3D printing for dose-finding trials are emphasized. On the other hand, current challenges in adequate dosing, regulatory compliance, adherence to quality standards, and maintenance of intellectual property need to be addressed for 3D printing to close the gap in personalized oral medication.

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“…Within the realm of pharmaceuticals, 3DP and other printing technologies has gotten substantial attention for its capacity to generate individualized and unique medications or 3D printed tablets already increasingly from 2011 onwards [6][7][8][9][10]. The pharmaceutical 3DP allows for the creation of medications with a wide spectrum of dosage levels, shapes, flavors, colors, drug combinations, and drug release profiles, all tailored to the specific needs of each patient or disease condition [11][12][13][14]. It has been stated that these attributes make this technology particularly advantageous for diverse patient groups, including pediatrics, geriatrics, those on multiple medications, and individuals with rare diseases.…”

Section: Introductionmentioning

confidence: 99%

Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets

Sandler,

Shokraneh,

Bahman

et al. 2024

Preprint

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Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is in a verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenting challenges in terms of consistency, dosage accuracy, quality control, contamination and scalability. However, the emergence of cutting-edge technologies has paved a way for a new era for pharmacy compounding, promising to redefine the way medications are prepared and delivered as pharmacy-tailored personalized medicines. In this multi-site study, more than 30 hospitals and community pharmacies from 8 countries in Europe utilized a novel automated dosing approach inspired by 3D printing for compounding of non-sterile propranolol hydrochloride tablets. CuraBlend® excipient base, a GMP manufactured pharma-ink, intended for automated compounding applications was used. A standardized study protocol to test the automated dosing of tablets with variable weights was performed in all participating pharmacies in 4 different iterative phases. Integrated quality control was performed with an in-process scale and NIR spectroscopy supported by HPLC content uniformity measurements. In total, 6088 propranolol tablets were produced at different locations during this study. It was shown that the dosing accuracy of the process increased from about 90% to 100% from phase 1 to phase 4 by making improvements to the formulation and the hardware solutions. The results indicate that through this novel automated and quality-controlled compounding approach extemporaneous pharmacy manufacturing can take a giant leap forward towards automation and digital manufacture of dosage forms in hospital pharmacies and compounding pharmacies.

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3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder

Cited by 13 publications

References 23 publications

A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications

A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications

The potential of three-dimensional printing for pediatric oral solid dosage forms

Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets

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