3D printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for bone regeneration

Li, Xiangjia; Yuan, Yuan; Liu, Luyang; Leung, Yuen Shan; Chen, Yiyu; Guo, Yuxing; Chai, Yang; Chen, Yong

doi:10.1007/s42242-019-00056-5

Cited by 108 publications

(76 citation statements)

References 63 publications

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“…The computer‐generated model of the MNs was virtually sliced to generate a series of mask projection images with the slicing thickness ranging from 10 µm to 25 µm for a smooth surface (Figure 3a and Figure S4, Supporting Information). [ 54 ] The exposure time was adjusted based on the light intensity and the photosensitivity of the printing material (ranging from 20 to 35 s) to improve the fabrication accuracy. [ 53 ]…”

Section: Methodsmentioning

confidence: 99%

Limpet Tooth‐Inspired Painless Microneedles Fabricated by Magnetic Field‐Assisted 3D Printing

Shan

Yang

et al. 2020

Adv Funct Materials

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Microneedle arrays show many advantages in drug delivery applications due to their convenience and reduced risk of infection. Compared to other microscale manufacturing methods, 3D printing easily overcomes challenges in the fabrication of microneedles with complex geometric shapes and multifunctional performance. However, due to material characteristics and limitations on printing capability, there are still bottlenecks to overcome for 3D printed microneedles to achieve the mechanical performance needed for various clinical applications. The hierarchical structures in limpet teeth, which are extraordinarily strong, result from aligned fibers of mineralized tissue and protein‐based polymer reinforced frameworks. These structures provide design inspiration for mechanically reinforced biomedical microneedles. Here, a bioinspired microneedle array is fabricated using magnetic field‐assisted 3D printing (MF‐3DP). Micro‐bundles of aligned iron oxide nanoparticles (aIOs) are encapsulated by polymer matrix during the printing process. A bioinspired 3D‐printed painless microneedle array is fabricated, and suitability of this microneedle patch for drug delivery during long‐term wear is demonstrated. The results reported here provide insights into how the geometrical morphology of microneedles can be optimized for the painless drug delivery in clinical trials.

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Section: Methodsmentioning

confidence: 99%

Limpet Tooth‐Inspired Painless Microneedles Fabricated by Magnetic Field‐Assisted 3D Printing

Shan

Yang

et al. 2020

Adv Funct Materials

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“…The compressive strength that the material has is anisotropic, a property that bears similarity to human bones. 3D printed hydroxyapatite has structural properties that allow it to bear load and have a high strain [36,37]. II) Hyperelastic bone -Hyperelastic bone is a 3D printing material, that is primarily composed of bone mineral or hydroxyapatite, along with a biocompatible material like polyglycolic acid [39,39].…”

Section: 6mentioning

confidence: 99%

Emerging trend in manufacturing of 3D biomedical components using selective laser sintering: A review

Kumar¹,

syed²

2020

E3S Web Conf.

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Additive manufacturing (also known as 3D printing) process is an emerging technique for the fabrication of biomedical components. Selective laser sintering or melting is one of the widely used additive printing technology for manufacturing of metallic and non-metallic components used in the industry. This review paper presents, a summary of the published research papers on the fabrication of biomedical components using selective laser sintering technique. Therefore, author meticulously attempted to investigate individual biocompatible material-wise review which includes Ti6Al4V, Ti-7.5 Mo alloy, β-Ti35Zr28Nb, PEEK, PA2200, and Polyamide/Hydroxyapatite. In addition, this article also explores the effects of the various laser sintering process parameters such as laser power, scanning speed, density of the material on the mechanical properties, tribological properties, porosity and surface roughness of the fabricated alloy. Moreover, the author also investigated challenges and future prospective of the laser processing of biomedical implants.

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“…Three-dimensional (3D) printing has been developed as one of the most promising fabrication techniques able to produce patient-personalized scaffolds. The possibility to control porosity and interconnectivity provides a valuable tool to enhance cell-biomaterial or tissue-specific interactions, including the access and distribution of cells into the scaffold core, and to improve the transportation of nutrients and oxygen [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Currently, the main strategies in bone tissue engineering are focused on the development of 3D printed scaffolds based on biomimetic composites, with high precision and reproducibility [ 3 , 6 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…The main combination of biomaterials for composite scaffolds fabrication as bone tissue mimics was based on calcium phosphates as an inorganic component and hydrogels precursors as organic phase [ 3 , 12 , 17 ]. Hydroxyapatite, β-tricalcium phosphate or a combination of them, were broadly used to produce 3D printed composites due to their intrinsic bioactivity and osteoconductivity [ 2 , 3 , 6 , 8 , 9 , 10 , 12 , 17 , 22 , 24 ]. Apart from those, calcium silicates are another important bioceramic class which have gained considerable attention due to their outstanding bioactivity for biomimetic surface mineralization [ 22 , 23 , 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Development of 3D Bioactive Scaffolds through 3D Printing Using Wollastonite–Gelatin Inks

et al. 2020

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The bioactivity of scaffolds represents a key property to facilitate the bone repair after orthopedic trauma. This study reports the development of biomimetic paste-type inks based on wollastonite (CS) and fish gelatin (FG) in a mass ratio similar to natural bone, as an appealing strategy to promote the mineralization during scaffold incubation in simulated body fluid (SBF). High-resolution 3D scaffolds were fabricated through 3D printing, and the homogeneous distribution of CS in the protein matrix was revealed by scanning electron microscopy/energy-dispersive X-ray diffraction analysis (SEM/EDX) micrographs. The bioactivity of the scaffold was suggested by an outstanding mineralization capacity revealed by the apatite layers deposited on the scaffold surface after immersion in SBF. The biocompatibility was demonstrated by cell proliferation established by MTT assay and fluorescence microscopy images and confirmed by SEM micrographs illustrating cell spreading. This work highlights the potential of the bicomponent inks to fabricate 3D bioactive scaffolds and predicts the osteogenic properties for bone regeneration applications.

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3D printing of hydroxyapatite/tricalcium phosphate scaffold with hierarchical porous structure for bone regeneration

Cited by 108 publications

References 63 publications

Limpet Tooth‐Inspired Painless Microneedles Fabricated by Magnetic Field‐Assisted 3D Printing

Limpet Tooth‐Inspired Painless Microneedles Fabricated by Magnetic Field‐Assisted 3D Printing

Emerging trend in manufacturing of 3D biomedical components using selective laser sintering: A review

Development of 3D Bioactive Scaffolds through 3D Printing Using Wollastonite–Gelatin Inks

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