3D printing of high-strength chitosan hydrogel scaffolds without any organic solvents

Zhou, Luyu; Ramezani, Hamed; Sun, Miao; Xie, Mingjun; Nie, Jing; Lv, Shang; Cai, Jie; Fu, Jianzhong; He, Yong

doi:10.1039/d0bm00896f

Cited by 95 publications

(49 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 9 ] Thus it is very important to optimize the formula and discuss the performances of the precursor hydrogel inks. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

Liu

et al. 2021

Macromolecular Bioscience

View full text Add to dashboard Cite

In this work, a 3D printed double‐network (DN) hydrogel scaffold is designed with chitosan (CS) and polyvinyl alcohol (PVA) as the framework matrix. The addition of PVA into the CS‐based hydrogel clearly enhances the mechanical properties and lowers the swelling behaviors of the hydrogels. The crosslinking of CS with genipin can perform the pre‐crosslinking to improve the viscosity and 3D printability of the hydrogel precursor, while increasing the PVA content results in lowering the viscosity and 3D printability of the pre‐crosslinked hydrogel. The antibacterial property results of the DN hydrogel display that the hydrogel have favorable long‐lasting antibacterial ability. The appropriate pre‐crosslinked hydrogel with the CS/PVA mass ratio of 3:10 and pre‐crosslinking time of 7 h is used for 3D printing to prepare the 3D printed porous DN hydrogels. Moreover, the anti‐tumor drug doxorubicin (DOX) is loaded into the 3D printed porous DN hydrogels and the in vitro release study displays the sustainable drug release behavior. And the DOX release from hydrogel scaffold can be adjusted by the pH value of release environment. All of the results indicate that the porous DN CS/PVA hydrogel scaffolds have great application potential for tissue regeneration.

show abstract

“…[ 9 ] Thus it is very important to optimize the formula and discuss the performances of the precursor hydrogel inks. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

Liu

et al. 2021

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…Furthermore, the inflammatory factors (e.g. tumor necrosis factor-α (TNF-α), interleukins 1β and 6 (IL-1β and IL-6)) after implanting vascular scaffolds can be measured by ELISA [ 174 ]. And the degradability is verified by the weight reduction of scaffolds after placed in culture mediums after some days.…”

Section: Transformation Of Vascular Scaffolds To Clinical Productivitmentioning

confidence: 99%

3D printing of tissue engineering scaffolds: a focus on vascular regeneration

et al. 2021

View full text Add to dashboard Cite

“…16 Zhou et al printed chitosan presolution (alkali solution) using a high-temperature method. 17 However, the long fabrication time and the use of acidic or alkaline media to dissolve the chitosan pre-gel solution in these methods render it unsuitable for direct cell encapsulation and biomedical application. Alternatively, Liu et al reported a 3D printed chitosan-based hydrogel using photocrosslinking of phenol functionalized chitosan and dibenzaldehyde-terminated telechelic poly(ethylene glycol) (DF-PEG) pre-gel crosslinked by dynamic imine bonds.…”

Section: Introductionmentioning

confidence: 99%

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

et al. 2022

View full text Add to dashboard Cite

show abstract

3D printing of high-strength chitosan hydrogel scaffolds without any organic solvents

Abstract: 3D printing of chitosan hydrogel has attracted wide interests because of its excellent biocompatibility, antibacterial activities, biodegradability, none-toxicity and low cost. However, chitosan inks are often involved in toxic and...

Cited by 95 publications

References 43 publications

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

Preparation of 3D Printed Chitosan/Polyvinyl Alcohol Double Network Hydrogel Scaffolds

3D printing of tissue engineering scaffolds: a focus on vascular regeneration

Synergistic complexation of phenol functionalized polymer induced in situ microfiber formation for 3D printing of marine-based hydrogels

Contact Info

Product

Resources

About