3D printing individualized heel cup for improving the self-reported pain of plantar fasciitis

Li, Lan; Lijun, Yang; Yu, Fei; Shi, Jianping; Zhu, Linli; Yang, Xin; Teng, Huajian; Wang, Xingsong; Jiang, Qing

doi:10.1186/s12967-018-1547-y

Cited by 29 publications

(25 citation statements)

References 44 publications

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“…The scaffold and the block were defined as Ti6Al4V alloys, and the bases were defined as bone material. The material parameters were selected from the literature, as shown in Table 2 [28], [29].…”

Section: Methodsmentioning

confidence: 99%

Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models

Shi

Zhang

et al. 2019

Journal of Orthopaedic Translation

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BackgroundThe graded porous structures were designed using triply periodic minimal surfaces models to mimic the biomechanical properties of bone. The mechanical properties and bone formation ability were evaluated to explore the feasibility of the design method in bone tissue engineering.MethodsThe scaffolds were designed using a P-surface with different pore sizes. All materials were fabricated using 3D printing technology and the mechanical properties were tested by an electronic universal testing device. The biomechanical properties were then analyzed by finite element method, while the ontogenesis of the material in vivo was examined by implanting the scaffolds for five weeks in pigs.ResultsAccording to the obtained results, the pore size ranged between 100 μm to about 700 μm and porosity were around 49.54%. The graded porous architectures can decrease the stiffness of implants and reduce the stress shielding effect. In addition, these porous structures can stimulate bone ingrowth and achieve a stable interface between implants and surrounding bone tissues after 5 weeks' implantation. The micro-CT results also demonstrated the obviously bone formation around all the porous structures.ConclusionTo sum up, the triply periodic minimal surfaces based graded porous structure is effective in decreasing the stress shielding effect, promoting early osteogenesis and osteointegration. This is the first research to explore the effect of this kind of porous structures on bone formation in vivo where the obtained results supported the previous theoretical research on the application potential in bone tissue engineering.The translational potential of this articlePorous architecture designed using triply periodic minimal surface models can achieve gradually changed pore size and appropriate porosity for bone regeneration. This kind of structure can mimic the Young’s modulus of natural bone tissue, improve the stress transmission capability and dismiss the stress shielding effect. It also can stimulate the early bone integration in vivo and enhance the binding force between bone and implants, which may bring a new design method for orthopaedic implants and their surface structure.

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Section: Methodsmentioning

confidence: 99%

Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models

Shi

Zhang

et al. 2019

Journal of Orthopaedic Translation

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“…The bone material behavior was linear with an elastic modulus ( E ) of 7300 MPa and a Poisson’s ratio (ν) of 0.3 [15]. The articular cartilage and the menisci were assumed to be composed of a single-phase linear elastic and isotropic material with the following average properties: E = 15 MPa, ν = 0.475 and E = 120 MPa, ν = 0.45, respectively [16–19].…”

Section: Methodsmentioning

confidence: 99%

The biomechanical changes of load distribution with longitudinal tears of meniscal horns on knee joint: a finite element analysis

Zhang

Lijun

et al. 2019

J Orthop Surg Res

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Background Meniscal horns are important structures of meniscus, and longitudinal tears of these places could significantly change the load distribution among the knee joint. Few studies concerned the stress concentrated on bones, which may induce the osteonecrosis of subchondral bone. The goal of this study was to construct a finite element (FE) model with high fidelity of the knee joint and evaluate the biomechanical changes of load distribution of components after longitudinal tears of the horns of meniscus. Methods Computed tomography and magnetic resonance images were used to develop the FE model, and two different kinds of simulations, the vertical and the anterior load, mimicking the static stance and slight flexion simulations, were applied after longitudinal tears of the horns of meniscus. Results Significantly elevated peak compressive and shear stress was observed on the menisci, cartilages, and subchondral bones, and enlarged meniscus extrusion was noticed. Between all the four types of longitudinal tears investigated in this study, longitudinal tears at the posterior horn of the medial meniscus were found to be the most significant. Conclusions These findings showed that longitudinal tears of the meniscal horns lead to increased magnitude and changed distribution of stress and indicated the important role of posterior horn of medial meniscus. This may contribute to the mechanism between meniscal tears and spontaneous subchondral bone osteonecrosis. Electronic supplementary material The online version of this article (10.1186/s13018-019-1255-1) contains supplementary material, which is available to authorized users.

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“…All the materials were considered isotropic and liner-elastic. The material parameters were selected form the literature, as shown in Table 1 (45,46).…”

Section: Fe Model Operationmentioning

confidence: 99%

Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds

Lijun

et al. 2019

Ann. Transl. Med

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Background: Titanium implants are widely used in orthopedic and dental for more than 30 years. Its stable physicochemical properties and mechanical strength are indeed appropriate for implantation. However, the Bioinertia oxidized layer and higher elastic modulus often lead to the early implantation failure. Methods: In this study, we proposed a simple design of porous structure to minimize the disparity between scaffold and natural bone tissue, and introduced a one-step reaction to form a polydopamine (PDA) layer on the surface of titanium for the purpose of improving osteogenesis as well. The porous scaffolds with pore size of 400 μm and porosity of 44.66% were made by additive manufacturing. The cell behavior was tested by seeding MC3T3-E1 cells on Ti6Al4V films for 15 days. The biomechanical properties were then analyzed by finite element (FE) method and the in vivo osteogenesis effect was accordingly evaluated by implanting the scaffolds for 5 weeks in rabbits. Results: According to the achieved results, it was revealed that the immersion for 40 min with dopamine could significantly improve the cell adhesion. The proposed method for design of porous structure can avoid the stress shielding effect and bone growth inside the PDA coating scaffolds, which were observed at the early stage of bone healing process. Conclusions: It can be concluded that the proposed PDA coating method is effective in promoting early osteogenesis, as well as being easy to operate, and can be helpful in the future clinical application of titanium implants.

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3D printing individualized heel cup for improving the self-reported pain of plantar fasciitis

Cited by 29 publications

References 44 publications

Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models

Early osteointegration evaluation of porous Ti6Al4V scaffolds designed based on triply periodic minimal surface models

The biomechanical changes of load distribution with longitudinal tears of meniscal horns on knee joint: a finite element analysis

Polydopamine coating promotes early osteogenesis in 3D printing porous Ti6Al4V scaffolds

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