3D printing hybrid materials using fused deposition modelling for solid oral dosage forms

Krueger, Liam; Miles, Jared A.; Popat, Amirali

doi:10.1016/j.jconrel.2022.09.032

Cited by 29 publications

(20 citation statements)

References 91 publications

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Section: Incorporation Of Additivesmentioning

confidence: 99%

“…The incorporation of additives is a promising and potentially viable approach for increasing the dissolution rates of drugs from the FDM 3D-printed tablets. Indeed, Krueger et al [ 57 ] called the polymer-additive adducts hybrid materials since the additives can impart new properties to the polymers. Resulting in better performance.…”

Section: Current Strategies For the Development Of Rapid-release Fdm ...mentioning

confidence: 99%

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Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Serajuddin

2023

ADMET DMPK

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Since the approval of a 3D-printed tablet by the FDA in 2015 for marketing, there has been a great interest in 3D printing in the pharmaceutical field for the development of personalized and on-demand medications. Among various 3D printing methods explored for the development of oral solid dosage form like tablet, the fused deposition modeling (FDM) 3D-printing, where the drug-polymer mixtures are first converted into filaments by hot melt extrusion (HME) and then the filaments are printed into tablets using 3D printers by applying computer-aided design principles, has emerged as the most attractive option. However, no FDM 3D-printed tablets have yet been marketed as the technology faces many challenges, such as limited availability of pharmaceutical-grade polymers that can be printed into tablets, low drug-polymer miscibility, the need for high temperature for HME and 3D-printing, and slow drug release rates from tablets. These challenges are discussed in this article with a special focus on drug release rates since FDM 3D-printing usually leads to the preparation of slow-release tablets while the rapid release from dosage forms is often desired for optimal therapeutic outcomes of new drug candidates. Pros and cons of various strategies for the development of rapidly dissolving FDM 3D-printed tablets reported in the literature are reviewed. Finally, two case studies on emerging strategies for the development of rapidly dissolving FDM 3D-printed tablets are presented, where one outlines a systematic approach for formulating rapidly dissolving tablets, and the other describes a novel strategy to increase dissolution rates of drugs from FDM 3D-printed tablets, which at the same time can also increase drug-polymer miscibility and printability of tablets and lower processing temperatures. Thus, this overview and commentary discusses various issues involving the formulation of rapidly dissolving FDM 3D-printed tablets and provides guidance for the development of commercially viable products.

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Section: Incorporation Of Additivesmentioning

confidence: 99%

Section: Current Strategies For the Development Of Rapid-release Fdm ...mentioning

confidence: 99%

Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Serajuddin

2023

ADMET DMPK

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“…A 3D printing technique [ 14 , 15 ] is capable of selectively producing various products with specific structures through layer-by-layer printing and curing [ 16 ]. In the past decades, numerous dosages such as tablets [ 17 , 18 ], pellets [ 19 ], transdermal microneedles [ 20 ], hydrogels [ 21 ] and oral films [ 22 , 23 ] have been produced using this technology.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional-Printed Oral Films Based on LCD: Influence Factors of the Film Printability and Received Qualities

Xia

et al. 2023

Pharmaceutics

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As an oral mucosal drug delivery system, oral films have been of wide concern in recent years because of their advantages such as rapid absorption, being easy to swallow and avoiding the first-pass effect common for mucoadhesive oral films. However, the currently utilized manufacturing approaches including solvent casting have many limitations, such as solvent residue and difficulties in drying, and are not suitable for personalized customization. To solve these problems, the present study utilizes liquid crystal display (LCD), a photopolymerization-based 3D printing technique, to fabricate mucoadhesive films for oral mucosal drug delivery. The designed printing formulation includes PEGDA as the printing resin, TPO as the photoinitiator, tartrazine as the photoabsorber, PEG 300 as the additive and HPMC as the bioadhesive material. The influence of printing formulation and printing parameters on the printing formability of the oral films were elucidated in depth, and the results suggested that PEG 300 in the formulation not only provided the necessary flexibility of the printed oral films, but also improved drug release rate due to its role as pore former in the produced films. The presence of HPMC could greatly improve the adhesiveness of the 3D-printed oral films, but excessive HPMC increased the viscosity of the printing resin solution, which could strongly hinder the photo-crosslinking reaction and reduce printability. Based on the optimized printing formulation and printing parameters, the bilayer oral films containing a backing layer and an adhesive layer were successfully printed with stable dimensions, adequate mechanical properties, strong adhesion ability, desirable drug release and efficient in vivo therapeutic efficacy. All these results indicated that an LCD-based 3D printing technique is a promising alternative to precisely fabricate oral films for personalized medicine.

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“…Over the past 10 years, the number of research studies focused on the application of three dimensional (3D) printing by fused deposition modeling (FDM) in pharmaceutics has definitely grown, likely due to the cost-accessibility of desktop equipment and of the overall simplicity of the technique, even for unexperienced users [ Aho et al, 2019 ; Dumpa et al, 2021 ; Fuenmayor et al, 2018 ; Gupta et al, 2022 ; Joo et al, 2020 ; Melocchi et al, 2020a ]. Indeed, FDM is an extrusion-based additive process in which filaments, composed of thermoplastic polymeric formulations and obtained by hot melt extrusion (HME), are deposited through a nozzle in a series of overlapping layers on a build plate, following a software-controlled path [ Krueger et al, 2022 ; Parulski et al, 2021 ; Quodbach et al, 2022 ]. In this respect, the mutual movement of the printhead and of the build plate in x-, y- and z-directions enables the fabrication of the product bottom up, layer-by-layer.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the use of fused deposition modeling for the production of IR dosage forms containing Timapiprant

Uboldi

Chiappa

Pertile

et al. 2023

International Journal of Pharmaceutics: X

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3D printing hybrid materials using fused deposition modelling for solid oral dosage forms

Cited by 29 publications

References 91 publications

Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary

Three-Dimensional-Printed Oral Films Based on LCD: Influence Factors of the Film Printability and Received Qualities

Investigation on the use of fused deposition modeling for the production of IR dosage forms containing Timapiprant

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