3D printing fabrication of Ethylene-Vinyl Acetate (EVA) based intravaginal rings for antifungal therapy

Moroni, Sofia; Bischi, Francesca; Aluigi, Annalisa; Campana, Raffaella; Tiboni, Mattia; Casettari, Luca

doi:10.1016/j.jddst.2023.104469

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Notably, fused deposition modeling (FDM) is a thermal material extrusion technology that has been highly popularized due to its low cost, versatility, and ability to produce products with high mechanical strength [ 4 ]. Indeed, numerous drug delivery devices have been made by FDM 3DP, including tablets with immediate or controlled drug release, vaginal rings, orthodontic retainers, drug implants, catheters, nasal supports, and even devices that can treat prosthetic infections, a therapeutic intervention fraught with numerous challenges within contemporary medical and pharmaceutical domains [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Customizable Three-Dimensional Printed Earring Tap for Treating Affections Caused by Aesthetic Perforations

Pinho,

Lima,

Chen

et al. 2024

Pharmaceutics

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This work aimed to develop a three-dimensional (3D) wearable drug-loaded earring tap to treat affections caused by aesthetic perforations. The initial phase involved a combination of polymers to prepare filaments for fused deposition modeling (FDM) 3D printing using a centroid mixture design. Optimized filament compositions were used in the second phase to produce 3D printed earring taps containing the anti-inflammatory naringenin. Next, samples were assessed via physicochemical assays followed by in vitro skin permeation studies with porcine ear skin. Two filament compositions were selected for the study’s second phase: one to accelerate drug release and another with slow drug dissolution. Both filaments demonstrated chemical compatibility and amorphous behavior. The use of the polymer blend to enhance printability has been confirmed by rheological analysis. The 3D devices facilitated naringenin skin penetration, improving drug recovery from the skin’s most superficial layer (3D device A) or inner layers (3D device B). Furthermore, the devices significantly decreased transdermal drug delivery compared to the control containing the free drug. Thus, the resulting systems are promising for producing 3D printed earring taps with topical drug delivery and reinforcing the feasibility of patient-centered drug administration through wearable devices.

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Section: Introductionmentioning

confidence: 99%

Customizable Three-Dimensional Printed Earring Tap for Treating Affections Caused by Aesthetic Perforations

Pinho,

Lima,

Chen

et al. 2024

Pharmaceutics

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“…The studied composites can be utilized in potential electronic applications as well as in anti-corrosion paints, automotive materials, sensors, capacitors and batteries, in particular. In recent years, EVA, as a part of blends or composites, has been increasingly used in construction applications due to its chemical-physical properties [ 38 , 39 , 40 , 41 ], as well as in diverse areas such as the flexible 3D printing fabrication of medical devices, allowing for a continuous, sustained and controlled local delivery of the incorporated drug with a single application [ 42 , 43 ]. Additionally, it is also used in filled biocomposites or in cenosphere composites [ 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

A Macroscopic Interpretation of the Correlation between Electrical Percolation and Mechanical Properties of Poly-(Ethylene Vinyl Acetate)/Zn Composites

Agrisuelas,

Balart,

García-Jareño

et al. 2024

Materials

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Elastic composites were prepared using a procedure involving hot plates and zinc powder that was directly dispersed into an EVA matrix. The correlation between the zinc content and the conductive properties of the material was studied via impedance spectroscopy, the thermal properties of the material were studied via differential calorimetry and the mechanical properties of the composites were studied via tensile strength curves, representing an important advancement in the characterization of this type of composite material. The composites’ tensile strength and elongation at break decrease with the addition of filler since zinc particles act as stress-concentrating centres, while the composites’ hardness and Young’s modulus increase because of an increase in the stiffness of the material. The AC perturbation across the EVA/Zn composites was characterized using an RC parallel equivalent circuit that allowed us to easily measure their resistivity (ρp) and permittivity (εp). The dependence of these electrical magnitudes on the zinc content is correlated with their mechanical properties across the characteristic time constant τp = ρp·εp of this equivalent circuit. The dependence of the mechanical and electrical magnitudes on the zinc content is consistent with the formation of percolation clusters. The addition of graphite particles increases their potential performance. Three possible mechanisms for the electrical transport of the ac-perturbation across the EVA/Zn composites have been identified. Chemical corrosion in acid media causes the loss of zinc surface particles, but their bulk physical properties practically remain constant.

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Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects

Park,

Renuka,

Lee

et al. 2024

J. Pharm. Investig.

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3D printing fabrication of Ethylene-Vinyl Acetate (EVA) based intravaginal rings for antifungal therapy

Cited by 5 publications

References 34 publications

Customizable Three-Dimensional Printed Earring Tap for Treating Affections Caused by Aesthetic Perforations

Customizable Three-Dimensional Printed Earring Tap for Treating Affections Caused by Aesthetic Perforations

A Macroscopic Interpretation of the Correlation between Electrical Percolation and Mechanical Properties of Poly-(Ethylene Vinyl Acetate)/Zn Composites

Advancements of hot-melt extrusion technology to address unmet patient needs and pharmaceutical quality aspects

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