3D Printing Cellulose Hydrogels Using LASER Induced Thermal Gelation

Huber, Tim; Clucas, Don; Vilmay, Mathieu; Pupkes, Birte; Stuart, James; Dimartino, Simone; Fee, Conan J.

doi:10.3390/jmmp2030042

Cited by 9 publications

(5 citation statements)

References 52 publications

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“…Based on these factors, a synthetic method can then be chosen to best suit the characteristics of the final polymer product. These techniques include freeze drying [139], solvent casting [140,141], supercritical foaming [142,143], electrospinning [144][145][146], laser induced thermal gelation [147], 3D bio printing [148] chemical crosslinking [149,150] or physical crosslinking [150]. Each of which have their own discrete advantages and disadvantages which can be considered based on overall polymer requirements.…”

Section: Polymer Synthesis Methodsmentioning

confidence: 99%

Towards advanced wound regeneration

Man

Hoskins

2020

European Journal of Pharmaceutical Sciences

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Wound management is a major contributor towards the economic burden placed upon the national health service (NHS), serving as an important target for the development of advanced therapeutic interventions. The economic expenditure of wound care for the NHS exceeds £5 billion per annum, thus presenting a significant opportunity for the introduction of alternative treatments in regards to their approach in tackling the ever increasing prevalence of wound management associated problems. As most wounds typically fall under the acute or chronic category, it is therefore necessary to design a therapeutic intervention capable of effectively resolving the pathologies associated with each problem. Such an intervention should be of increased economic viability and therapeutic effectiveness when compared to standardized treatments, thus helping to alleviate the financial burden imposed upon the NHS. The purpose of this review is to critically analyse the various aspects associated with wound management, detailing the fundamental concepts of dermal regeneration, whilst also providing an evaluation of the different materials and methods that can be utilised to achieve maximal wound regeneration. The primary aspects of this review revolve around the three concepts of antibacterial methodology, enhancement of dermal regeneration and the utilisation of a carrier medium to facilitate the regenerative process. Each aspect is explored, conveying its justifications as a target for dermal regeneration, whilst offering various solutions towards the fulfilment of a therapeutic design that is both effective and financially feasible.

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Section: Polymer Synthesis Methodsmentioning

confidence: 99%

Towards advanced wound regeneration

Man

Hoskins

2020

European Journal of Pharmaceutical Sciences

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“…The list continues. Advanced research studies have been carried out to make 3D printing even more robust and cost-effective, resulting in novel devices [54][55][56], geometric modeling techniques [57,58], and materials [59]. The list continues.…”

Section: Introductionmentioning

confidence: 99%

Utilizing Fractals for Modeling and 3D Printing of Porous Structures

et al. 2021

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Porous structures exhibiting randomly sized and distributed pores are required in biomedical applications (producing implants), materials science (developing cermet-based materials with desired properties), engineering applications (objects having controlled mass and energy transfer properties), and smart agriculture (devices for soilless cultivation). In most cases, a scaffold-based method is used to design porous structures. This approach fails to produce randomly sized and distributed pores, which is a pressing need as far as the aforementioned application areas are concerned. Thus, more effective porous structure design methods are required. This article presents how to utilize fractal geometry to model porous structures and then print them using 3D printing technology. A mathematical procedure was developed to create stochastic point clouds using the affine maps of a predefined Iterative Function Systems (IFS)-based fractal. In addition, a method is developed to modify a given IFS fractal-generated point cloud. The modification process controls the self-similarity levels of the fractal and ultimately results in a model of porous structure exhibiting randomly sized and distributed pores. The model can be transformed into a 3D Computer-Aided Design (CAD) model using voxel-based modeling or other means for digitization and 3D printing. The efficacy of the proposed method is demonstrated by transforming the Sierpinski Carpet (an IFS-based fractal) into 3D-printed porous structures with randomly sized and distributed pores. Other IFS-based fractals than the Sierpinski Carpet can be used to model and fabricate porous structures effectively. This issue remains open for further research.

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“…This behavior was explored previously by locally heating the cellulose solution beyond its gelation point using a focused laser beam. [22]. In our previous work, a cellulose gel formed from dissolving excess cellulose in a solution of urea and sodium hydroxide was 3D printed and the effect of cellulose gel viscosity on 3D printed part resolution was studied [18].…”

Section: Introductionmentioning

confidence: 99%

A Novel Additive Manufacturing Method of Cellulose Gel

et al. 2021

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Screen-additive manufacturing (SAM) is a potential method for producing small intricate parts without waste generation, offering minimal production cost. A wide range of materials, including gels, can be shaped using this method. A gel material is composed of a three-dimensional cross-linked polymer or colloidal network immersed in a fluid, known as hydrogel when its main constituent fluid is water. Hydrogels are capable of absorbing and retaining large amounts of water. Cellulose gel is among the materials that can form hydrogels and, as shown in this work, has the required properties to be directly SAM, including shear thinning and formation of post-shearing gel structure. In this study, we present the developed method of SAM for the fabrication of complex-shaped cellulose gel and examine whether successive printing layers can be completed without delamination. In addition, we evaluated cellulose SAM without the need for support material. Design of Experiments (DoE) was applied to optimize the SAM settings for printing the novel cellulose-based gel structure. The optimum print settings were then used to print a periodic structure with micro features and without the need for support material.

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3D Printing Cellulose Hydrogels Using LASER Induced Thermal Gelation

Cited by 9 publications

References 52 publications

Towards advanced wound regeneration

Towards advanced wound regeneration

Utilizing Fractals for Modeling and 3D Printing of Porous Structures

A Novel Additive Manufacturing Method of Cellulose Gel

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