3D printing‐assisted fabrication of double‐layered optical tissue phantoms for laser tattoo treatments

Kim, Hanna; Hau, Nguyen Trung; Chae, Yu-Gyeong; Lee, Byeong-Il; Kang, Hyun Wook

doi:10.1002/lsm.22469

Cited by 10 publications

(8 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although their magnitudes are on the higher end, they still fall within the range of established values. Further comparisons can be seen in Figure S2, where the absorption coefficient of this OTP is compared with other epidermal OTPs from the literature. − The values of this work are comparable to that of other publications, with a moderate bias toward OTPs with higher degrees of pigmentation. Thus, although the absorption coefficient values of the epidermis OTP are reasonable, they may be better suited for modeling the absorption coefficients of darker pigmented skin tones rather than those of lighter skin.…”

Section: Resultssupporting

confidence: 74%

Optical Epidermal Mimicry from Ultraviolet to Infrared Wavelengths

Caratenuto

Wan

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Optical tissue phantoms present substantial value for medical imaging and therapeutic applications. We have developed an epidermal tissue phantom to mimic the optical properties of human skin from the ultraviolet to the infrared region, exceeding the breadth of existing studies. An epoxy matrix is combined with melanin-mimicking polydopamine via a cost-effective fabrication strategy. Reflectance and transmittance measurements enable calculation of the wavelength-dependent complex refractive index and absorption coefficient. Results are compared with literature data to establish agreement with a real human epidermis. By analyzing emissive power at a typical skin temperature, the epidermal tissue phantom is shown to accurately mimic the radiative properties of human skin. This simple, multifunctional material represents a promising substitute for human tissue for a variety of medical and bioengineering applications.

show abstract

Section: Resultssupporting

confidence: 74%

Optical Epidermal Mimicry from Ultraviolet to Infrared Wavelengths

Caratenuto

Wan

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…Extrusion printing was also used by Kim et al to produce artificial skin phantoms mimicking human skin as catalogued by color and tone (Fitzpatrick skin types I–VI) in order to match the corresponding optical and mechanical properties in laser tattoo removal applications . Epidermal‐dermal phantoms were printed using gelatin and agar with different concentrations of coffee and TiO 2 added to mimic the melanin variations responsible for skin color and tone.…”

Section: Advanced Tissue Engineering Approaches To Regenerate Skinmentioning

confidence: 99%

“…Bilayered scaffolds were designed to match the thicknesses of epidermis and dermis, 150 µm and 1 mm, respectively. The resins were successfully extruded into 30 µm thick layers, producing overall a 138 µm thick epidermis and 810 µm thick dermis with optical properties emulating various tones of the human skin . This addresses an important aspect of skin tissue engineering regarding the complete recapitulation of native skin pigments and texture which is discussed further in the clinical section.…”

Section: Advanced Tissue Engineering Approaches To Regenerate Skinmentioning

confidence: 99%

Current and Future Perspectives on Skin Tissue Engineering: Key Features of Biomedical Research, Translational Assessment, and Clinical Application

Navarro

Coburn

et al. 2019

Adv Healthcare Materials

157

View full text Add to dashboard Cite

The skin is responsible for several important physiological functions and has enormous clinical significance in wound healing. Tissue engineered substitutes may be used in patients suffering from skin injuries to support regeneration of the epidermis, dermis, or both. Skin substitutes are also gaining traction in the cosmetics and pharmaceutical industries as alternatives to animal models for product testing. Recent biomedical advances, ranging from cellular‐level therapies such as mesenchymal stem cell or growth factor delivery, to large‐scale biofabrication techniques including 3D printing, have enabled the implementation of unique strategies and novel biomaterials to recapitulate the biological, architectural, and functional complexity of native skin. This progress report highlights some of the latest approaches to skin regeneration and biofabrication using tissue engineering techniques. Current challenges in fabricating multilayered skin are addressed, and perspectives on efforts and strategies to meet those limitations are provided. Commercially available skin substitute technologies are also examined, and strategies to recapitulate native physiology, the role of regulatory agencies in supporting translation, as well as current clinical needs, are reviewed. By considering each of these perspectives while moving from bench to bedside, tissue engineering may be leveraged to create improved skin substitutes for both in vitro testing and clinical applications.

show abstract

“…Kim et al applied a combination of gelatin and agar with extrusion printing to create skin substitutes for the treatment of laser tattoo removal. 53 Multiple skin types were emulated, with varying colors and light absorption, to accommodate multiple different skin types. For all types, constructs were determined to be of 138.5 -0.1 lm and 0.81 -0.04 mm thickness for the epidermis and dermis, respectively, which is relatively low, but within the range of native human skin.…”

Section: Skin Printingmentioning

confidence: 99%

“…For all types, constructs were determined to be of 138.5 -0.1 lm and 0.81 -0.04 mm thickness for the epidermis and dermis, respectively, which is relatively low, but within the range of native human skin. 53 Cubo et al printed a skin construct with a dermal layer consisting of human dermal fibroblasts, CaCl 2 , and human plasma. 2 Interestingly, the authors applied a printing technique whereby the ink is mixed during the printing process.…”

Section: Skin Printingmentioning

confidence: 99%

Three-Dimensional Printing and Cell Therapy for Wound Repair

Kogelenberg

Yue

Dinoro

et al. 2018

Advances in Wound Care

View full text Add to dashboard Cite

Skin tissue damage is a major challenge and a burden on healthcare systems, from burns and other trauma to diabetes and vascular disease. Although the biological complexities are relatively well understood, appropriate repair mechanisms are scarce. Three-dimensional bioprinting is a layer-based approach to regenerative medicine, whereby cells and cell-based materials can be dispensed in fine spatial arrangements to mimic native tissue. Various bioprinting techniques have been employed in wound repair-based skin tissue engineering, from laser-induced forward transfer to extrusion-based methods, and with the investigation of the benefits and shortcomings of each, with emphasis on biological compatibility and cell proliferation, migration, and vitality. Development of appropriate biological inks and the vascularization of newly developed tissues remain a challenge within the field of skin tissue engineering. Progress within bioprinting requires close interactions between material scientists, tissue engineers, and clinicians. Microvascularization, integration of multiple cell types, and skin appendages will be essential for creation of complex skin tissue constructs.

show abstract

3D printing‐assisted fabrication of double‐layered optical tissue phantoms for laser tattoo treatments

Cited by 10 publications

References 33 publications

Optical Epidermal Mimicry from Ultraviolet to Infrared Wavelengths

Optical Epidermal Mimicry from Ultraviolet to Infrared Wavelengths

Current and Future Perspectives on Skin Tissue Engineering: Key Features of Biomedical Research, Translational Assessment, and Clinical Application

Three-Dimensional Printing and Cell Therapy for Wound Repair

Contact Info

Product

Resources

About