3D Printed Tubular Scaffolds with Massively Tailorable Mechanical Behavior

Abstract

The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adem.202200479.

A textile-reinforced composite vascular graft that modulates macrophage polarization and enhances endothelial cell migration, adhesion and proliferation in vitro

“…The strength of the vascular graft determines the safety of the vascular graft once implanted. As shown in this study, the PLA textile reinforcement provided the primary mechanical strength, but there are many factors that can influence the bursting strength and suture retention strength of a vascular graft, including, but not limited to, the type of material, 35 the structural design, 36–38 the density and thickness, 39,40 the method of fabrication 41 and post-fabrication treatments such as crosslinking and heat-setting. 6,13,42 We particularly investigated the impact of the number of PLA filaments that were plied together for the fabrication of the textile reinforcement.…”

Volumetric Printing across Melt Electrowritten Scaffolds Fabricates Multi-Material Living Constructs with Tunable Architecture and Mechanics

“…This allows the rhomboid geometry to assume vastly different mechanical properties depending on the chosen winding angle. [45] The aforementioned effect is presented in the recorded difference between the 34° (Peak Stress 28.7 ± 4.9 kPa / Young’s Modulus 3.5 ± 0.3 kPa) and 70° (Peak Stress 73.0 ± 21.5 kPa / Young’s Modulus 10.8 ± 3.3 kPa) rhomboid orientations (Figure 3D). The deviation between the generated samples is minimal within their group (apart from the 70° rhomboid constructs), highlighting the stable manufacturing process of the VolMEW constructs.…”

“…A similar profile can be obtained with the rhombic MEW reinforcements at low winding angles (34°), while stiffer meshes in the radial direction can be obtained at higher winding angles (70°). [45] To enable a comparison to natural tissues, two porcine coronary arteries were measured in the same fashion as the VolMEW constructs. When comparing the rhomboid constructs to the porcine coronary arteries, the 70° (Blood Vessel 1: 72.4 kPa / 70°: 75.5 kPa) and 34° (Blood Vessel 2: 38.7 kPa / 34°: 37.3 kPa) VolMEW constructs showed a good approximation of the maximum stress levels, while the 34° rhomboid reinforced constructs also showed a comparable overall curve trajectory to the physiological specimens (Figure 3F).…”

Volumetric Printing Across Melt Electrowritten Scaffolds Fabricates Multi‐Material Living Constructs with Tunable Architecture and Mechanics

“…This allows the rhomboid geometry to assume vastly different mechanical properties depending on the chosen winding angle. [ 49 ] The aforementioned effect is presented in the recorded difference between the 34° (Peak Stress 28.7 ± 4.9 kPa/Young's modulus 3.5 ± 0.3 kPa) and 70° (Peak Stress 73.0 ± 21.5 kPa/Young's modulus 10.8 ± 3.3 kPa) rhomboid orientations (Figure 3D). The deviation between the generated samples is minimal within their group (apart from the 70° rhomboid constructs), highlighting the stable manufacturing process of the VolMEW constructs.…”