3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration

Correia, Tiago Ruivo; Figueira, Daniela Sofia Rodrigues; Sá, Kevin Domingos de; Miguel, Sónia P.; Fradique, Ricardo; Mendonça, António; Correia, Ilídio J.

doi:10.1016/j.ijbiomac.2016.06.004

Cited by 52 publications

(40 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Every year, millions of people worldwide are affected by distinctive and complex bone-related pathologies, including infectious diseases, degenerative and genetic conditions, cancers, and fractures [ 188 ]. Unfortunately, the opportunistic contamination and colonization of orthopedic implants represent major concerns in osseous-tissue replacement strategies, since the related infections are associated with high morbidity [ 189 ].…”

Section: Silver Nanoparticles For Bone Healingmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

View full text Add to dashboard Cite

During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

show abstract

Section: Silver Nanoparticles For Bone Healingmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

View full text Add to dashboard Cite

show abstract

“…3D scaffolds with a porosity structure is suitable for loading ions, nanoparticles, and biomolecules to achieve multifunctional application. 130 In Correia et al study, 131 the tricalcium phosphate (TCP)/sodium alginate (SA) scaffolds were produced by 3DP. Subsequently, AgNPs were incorporated into scaffolds through two different methods, direct incorporation and physical adsorption.…”

Section: Plasma Electrolytic Oxidation (Peo)mentioning

confidence: 99%

“…Both of them present appropriate mechanical properties, biocompatibility, and bactericidal activity, which is suitable for being used in bone tissue regeneration ( Figure 6). 131 Similarly, graphene oxide and AgNPs nanocomposites were successfully modified on the β-TCP scaffolds by a simple soaking method to achieve biofunctions with antibacterial and osteogenic activity. 132 However, through soaking method, AgNP burst was released from the 3D scaffolds in short time, and this manner easily causes cytotoxicity.…”

Section: Plasma Electrolytic Oxidation (Peo)mentioning

confidence: 99%

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Qing

Cheng

et al. 2018

IJN

723

362

View full text Add to dashboard Cite

Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.

show abstract

“…Antimicrobial 3D printed parts have been intensively investigated in recent years due to the wide range of applications, including bone tissue engineering regeneration [84,85] to treat bone fractures [86], the fabrication of biomedical devices that are able to prevent biofilm formation [8], the fabrication of wound dressings [87], or the fabrication of scaffolds, just to mention few of them [88].…”

Section: Antimicrobial Polymers Blends and Composites In Additivmentioning

confidence: 99%

Antimicrobial Polymers for Additive Manufacturing

González‐Henríquez

Sarabia-Vallejos

Hernández

2019

IJMS

View full text Add to dashboard Cite

Three-dimensional (3D) printing technologies can be widely used for producing detailed geometries based on individual and particular demands. Some applications are related to the production of personalized devices, implants (orthopedic and dental), drug dosage forms (antibacterial, immunosuppressive, anti-inflammatory, etc.), or 3D implants that contain active pharmaceutical treatments, which favor cellular proliferation and tissue regeneration. This review is focused on the generation of 3D printed polymer-based objects that present antibacterial properties. Two main different alternatives of obtaining these 3D printed objects are fully described, which employ different polymer sources. The first one uses natural polymers that, in some cases, already exhibit intrinsic antibacterial capacities. The second alternative involves the use of synthetic polymers, and thus takes advantage of polymers with antimicrobial functional groups, as well as alternative strategies based on the modification of the surface of polymers or the elaboration of composite materials through adding certain antibacterial agents or incorporating different drugs into the polymeric matrix.

show abstract

3D Printed scaffolds with bactericidal activity aimed for bone tissue regeneration

Cited by 52 publications

References 58 publications

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Antimicrobial Polymers for Additive Manufacturing

Contact Info

Product

Resources

About