2019
DOI: 10.3390/mi11010017
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3D Printed Multi-Functional Hydrogel Microneedles Based on High-Precision Digital Light Processing

Abstract: Traditional injection and extraction devices often appear painful and cumbersome for patients. In recent years, polymer microneedles (MNs) have become a novel tool in the field of clinical medicine and health. However, the cost of building MNs into any shapes still remains a challenge. In this paper, we proposed hydrogel microneedles fabricated by high-precision digital light processing (H-P DLP) 3D printing system. Benefits from the sharp protuberance and micro-porous of the hydrogel microneedle, the micronee… Show more

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Cited by 75 publications
(46 citation statements)
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References 26 publications
(33 reference statements)
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“…So far, DLP printers have demonstrated their capacity to create dental models with high accuracy [ 22 ], as well as patient-specific drug delivery devices, including microneedle arrays on finger splints [ 23 ], hydrogel microneedles [ 24 ], non-dissolving suppository molds [ 25 ] and various implants [ 26 ]. Despite numerous advantages, the potential application of the DLP technique in the production and optimization of oral dosage forms has not been fully explored.…”
Section: Introductionmentioning
confidence: 99%
“…So far, DLP printers have demonstrated their capacity to create dental models with high accuracy [ 22 ], as well as patient-specific drug delivery devices, including microneedle arrays on finger splints [ 23 ], hydrogel microneedles [ 24 ], non-dissolving suppository molds [ 25 ] and various implants [ 26 ]. Despite numerous advantages, the potential application of the DLP technique in the production and optimization of oral dosage forms has not been fully explored.…”
Section: Introductionmentioning
confidence: 99%
“…Despite changing design features, the tip radii of MNs were at the range of 20–40 μm. Furthermore, higher printing layer heights result in faster printing, while yielding lower surface quality ( Krieger et al., 2019 ; Yao et al., 2020 ). Two-photon polymerization with a 780 nm light wavelength was used to produce soft elastomeric MN replica molds.…”
Section: Fabrication Of Mnsmentioning
confidence: 99%
“…Based on the DLP 3D printing technology, a new setup was built with high precision to print in micro-scale, being utilized for fabrication of MNs with a photosensitive hydrogel, which was cured with different blue light ( Yao et al., 2020 ). Alginate hydrogel (5 wt%), which is similar to human skin in terms of mechanical properties, was used as an artificial skin to study drug injection, extraction, and detection by the fabricated MNs.…”
Section: Emerging Applications In Biomedical Engineeringmentioning
confidence: 99%
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“…The design and fabrication of MNs determine their specic bioassay features. Many strategies (e.g., etching, 22,23 lithography, [24][25][26] micromachining, [27][28][29] and threedimensional (3D) printing [30][31][32] ) have been used for these purposes. Etching is one of the traditional methods to directly fabricate MNs through chemical reagents or physical ions, and is especially used to produce metal-based MNs.…”
Section: Design and Fabrication Strategies Of Mnsmentioning
confidence: 99%