3D printed modules for integrated microfluidic devices

Lee, Kyoung G.; Park, Kyun Joo; Seok, Seunghwan; Shin, Sujeong; Kim, Do Hyun; Park, Jung Youn; Heo, Yun Seok; Lee, Seok Jae; Lee, Tae Jae

doi:10.1039/c4ra05072j

Cited by 149 publications

(125 citation statements)

References 15 publications

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“…To create channels, the walls are polymerized by light followed by drainage of the uncured resin 3 , without need for assembly (bonding, alignment, etc.). Plastic modular 3D microfluidic circuits have been built with SL 4-6 . The availability of transparent biocompatible resins opens the possibility of fabricating biomedical devices by SL.…”

Section: Introductionmentioning

confidence: 99%

3D-printed microfluidic automation

et al. 2015

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Microfluidic automation – the automated routing, dispensing, mixing, and/or separation of fluids through microchannels – generally remains a slowly-spreading technology because device fabrication requires sophisticated facilities and the technology’s use demands expert operators. Integrating microfluidic automation in devices has involved specialized multi-layering and bonding approaches. Stereolithography is an assembly-free, 3D-printing technique that is emerging as an efficient alternative for rapid prototyping of biomedical devices. Here we describe fluidic valves and pumps that can be stereolithographically printed in optically-clear, biocompatible plastic and integrated within microfluidic devices at low cost. User-friendly fluid automation devices can be printed and used by non-engineers as replacement for costly robotic pipettors or tedious manual pipetting. Engineers can manipulate the designs as digital modules into new devices of expanded functionality. Printing these devices only requires the digital file and electronic access to a printer.

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Section: Introductionmentioning

confidence: 99%

3D-printed microfluidic automation

et al. 2015

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“…3,7 Electrodes have been incorporated into 3D-printed fluidic devices prepared by PolyJet technology, fused deposition modeling, and stereolithography for electrochemical sensing. 4–6 The devices described here for ECL measurements can similarly be used for biosensing, flow injection analysis, and other purposes that require relatively low sample volumes.…”

Section: Discussionmentioning

confidence: 99%

“…1 These printers have been used to produce modular fluidic components, 7 fluidic devices for various applications, 5,8,9 as well as open channels (600 μm dia.) that can be filled with colloidal metal suspensions to produce microelectronic components for building circuits.…”

mentioning

confidence: 99%

Electrochemiluminescence at Bare and DNA-Coated Graphite Electrodes in 3D-Printed Fluidic Devices

et al. 2015

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Clear plastic fluidic devices with ports for incorporating electrodes to enable electrochemiluminescence (ECL) measurements were prepared using a low-cost, desktop three-dimensional (3D) printer based on stereolithography. Electrodes consisted of 0.5 mm pencil graphite rods and 0.5 mm silver wires inserted into commercially available 1/4 in.-28 threaded fittings. A bioimaging system equipped with a CCD camera was used to measure ECL generated at electrodes and small arrays using 0.2 M phosphate buffer solutions containing tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate ([Ru(bpy)3]2+) with 100 mM tri-n-propylamine (TPA) as the coreactant. ECL signals produced at pencil graphite working electrodes were linear with respect to [Ru(bpy)3]2+ concentration for 9–900 μM [Ru(bpy)3]2+. The detection limit was found to be 7 μM using the CCD camera with exposure time set at 10 s. Electrode-to-electrode ECL signals varied by ±7.5%. Device performance was further evaluated using pencil graphite electrodes coated with multilayer poly(diallyldimethylammonium chloride) (PDDA)/DNA films. In these experiments, ECL resulted from the reaction of [Ru(bpy)3]3+ with guanines of DNA. ECL produced at these thin-film electrodes was linear with respect to [Ru(bpy)3]2+ concentration from 180 to 800 μM. These studies provide the first demonstration of ECL measurements obtained using a 3D-printed closed-channel fluidic device platform. The affordable, high-resolution 3D printer used in these studies enables easy, fast, and adaptable prototyping of fluidic devices capable of incorporating electrodes for measuring ECL.

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“…Recently, researchers have started to use 3D printing and other technologies to make 3D micro devices such as microfluidic systems [2][3][4][5][6][7][8] but few have studied in the rapid metallization for 3D micro systems. Ideally, metal-embedded 3D micro systems could enable various new applications.…”

Section: Introductionmentioning

confidence: 99%

3D printed RF passive components by liquid metal filling

Yang

Glick

et al. 2015

2015 28th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

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We present three-dimensional (3D) micro-scale electrical components and systems by means of 3D printing and a liquid-metal-filling technique. The 3D supporting polymer structures with hollow channels and cavities are fabricated from inkjet printing. Liquid metals made of silver particles suspension in this demonstration are then injected into the hollow paths and solidified to form metallic elements and interconnects with high electrical conductivity. In the proof-of-concept demonstrations, various radio-frequency (RF) passive components, including 3D-shaped inductors, capacitors and resistors are fabricated and characterized. High-Q inductors and capacitors up to 1 GHz have been demonstrated. This work establishes an innovative way to construct arbitrary 3D electrical systems with efficient and labor-saving processes.

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3D printed modules for integrated microfluidic devices

Abstract: Direct 3d printing for functional modules and their assembly into an integrated microfluidic device.

Cited by 149 publications

References 15 publications

3D-printed microfluidic automation

3D-printed microfluidic automation

Electrochemiluminescence at Bare and DNA-Coated Graphite Electrodes in 3D-Printed Fluidic Devices

3D printed RF passive components by liquid metal filling

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