3D‐Printed Microfluidics

Au, Anthony K.; Huynh, Wilson; Horowitz, Lisa F.; Folch, Albert

doi:10.1002/anie.201504382

Cited by 668 publications

(523 citation statements)

References 149 publications

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“…In the field of microfluidic applications, AM has begun to embrace the range of sizes and materials that appeal to the developers of microfluidic devices and reflect the recent advances in polymer-based systems, where no etching or dissolution processing is required and are thus more environmentally friendly and economically efficient [30]. Commercially available 3D printing systems for microfluidic devices fabrication and various 3D printed polymeric microfluidic components (microvalves and micropumps, droplet and emulsion chips, micromixers, microreactors, sensor cartridges and medical devices etc.)…”

Section: The Case Of A(n)m For 3d Microfluidic Devicesmentioning

confidence: 99%

Additive (nano)manufacturing perspectives: the use of nanofillers and tailored materials

2017

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Abstract. Additive manufacturing (AM) is identified to cost-effectively lower manufacturing inputs and outputs in small batch production, widely employed in customized and high-value manufacturing chains, such as aerospace and medical component manufacturing. Additive manufacturing has the potential to significantly lower life cycle energy demands of products and their CO 2 emissions. Moreover, AM holds promise of overturning many aspects of the economics of manufacturing, as it pays no heed to unit labour costs or traditional economies of scale. Advances in AM technology are yielding faster production times and enabling objects to be printed in multiple combinations of materials, colours and surface finishes. A significant portion of these advances lie on the development of advanced materials for AM processes, which is undeniably one of the main driving forces of the transition from Rapid Prototyping to the Direct Digital Manufacturing era. Industries are nowadays at the inflection point for AM technologies, which have moved from a much-hyped but largely unproven manufacturing processes, to a mature technological solution, with numerous competitive advantages and the ability to produce real, innovative, complex and robust products.

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Section: The Case Of A(n)m For 3d Microfluidic Devicesmentioning

confidence: 99%

Additive (nano)manufacturing perspectives: the use of nanofillers and tailored materials

2017

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“…Recent reviews describe state of the art 3D-printing for microfluidics applications. 18,19 All the demonstrations of 3D-printed microfluidics so far employ active flow control (usually pneumatic or centrifugal pumps). The resolution currently available with consumer grade 3D-printers is typically ≥ 200 µm 20,21 with ~ 1 µm surface roughness.…”

Section: D-printed Microfluidicsmentioning

confidence: 99%

“…The resolution obtained is similar to that reported for other state of the art stereolithographic 3D-printers in the literature. 18 . The 3D-printed reservoirs were 960 µm wide, 1,000 µm deep, and 6250 µm long with a volume of 6 µL, corresponding to 60 times the volume of typical microfabricated reservoirs.…”

Section: Capillaric Circuit For Autonomous Delivery Of Four Liquidsmentioning

confidence: 99%

3D-Printed Autonomous Capillaric Circuits^†

Olanrewaju

Robillard

Dagher

et al. 2016

Preprint

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Capillaric circuits (CCs) are advanced capillary microfluidic devices that move liquids in complex pre-programmed sequences without external pumps and valves -relying instead on microfluidic control elements powered by capillary forces. CCs were thought to require high-precision micro-scale features manufactured by photolithography in a cleanroom, which is slow and expensive. Here we present rapidly and inexpensively 3D-printed autonomous CCs. Molds for CCs were fabricated with a benchtop 3D-printer, Poly(dimethylsiloxane) replicas were made, and fluidic functionality was verified with aqueous solutions. We established design rules for 3D-printed CCs by a combination of modelling and experimentation. The functionality and reliability of 3D-printed trigger valves -an essential fluidic element that stops one liquid until flow is triggered by a second liquid -was tested for different geometries and different solutions. Trigger valves with geometries up to 80-fold larger than cleanroom-fabricated ones were found to function reliably. We designed 3D-printed retention burst valves that encode sequential liquid drainage and delivery using capillary pressure differences encoded by varying valve height and width. Using an electrical circuit analogue of the CC, we established circuit design rules for ensuring strictly sequential liquid delivery. We realized a 3D-printed CC with reservoir volumes 60 times larger than cleanroom-fabricated circuits and autonomously delivered eight liquids in a pre-determined sequence in < 7 min, exceeding the number of sequentially-encoded, self-regulated fluidic delivery events previously reported. Taken together, our results demonstrate that 3D-printing enables rapid prototyping of reliable CCs with improved functionality and potential applications in diagnostics, research and education.

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“…For example, various groups have used 3D printers to fabricate simple microfluidic devices with truly 3D geometries, including microfluidic devices without moving elements, such as resistors 20 and modular components 21 , as well as those with movable components, such as capacitors, diodes, and transistors 22 . Currently, the field of 3D-printed microfluidics is limited by the following: (1) the available resolution of the printer 20 ; (2) surface roughness 23,24 ; and (3) material types 25,26 ; however, 3D printing technologies are expected to rapidly advance and address these matters in the coming years.…”

Section: Introductionmentioning

confidence: 99%

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

et al. 2016

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A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined processes. Here, three-dimensional (3D) printed polymer molds are used to construct multilayer poly(dimethylsiloxane) (PDMS) devices by employing unique molding, bonding, alignment, and rapid assembly processes. Specifically, a novel single-layer, two-sided molding method is developed to realize two channel levels, non-planar membranes/valves, vertical interconnects (vias) between channel levels, and integrated inlet/outlet ports for fast linkages to external fluidic systems. As a demonstration, a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure, illustrating a high degree of flow rate control. In addition, multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic channels. Using integrated alignment marks to accurately position both stamps and individual layers, this technique is demonstrated by rapidly assembling a six-layer microfluidic device. By combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS, this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems.

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3D‐Printed Microfluidics

Cited by 668 publications

References 149 publications

Additive (nano)manufacturing perspectives: the use of nanofillers and tailored materials

Additive (nano)manufacturing perspectives: the use of nanofillers and tailored materials

3D-Printed Autonomous Capillaric Circuits^†

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

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3D‐Printed Microfluidics

Cited by 668 publications

References 149 publications

Additive (nano)manufacturing perspectives: the use of nanofillers and tailored materials

Additive (nano)manufacturing perspectives: the use of nanofillers and tailored materials

3D-Printed Autonomous Capillaric Circuits†

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

Contact Info

Product

Resources

About

3D-Printed Autonomous Capillaric Circuits^†