3D-Printed micro-optofluidic device for chemical fluids and cells detection

Cairone, Fabiana; Davi, S. K.; Stella, Giovanna; Guarino, Francesca; Recca, Giuseppe; Cicala, Gianluca; Bucolo, Maide

doi:10.1007/s10544-020-00487-3

Cited by 17 publications

(18 citation statements)

References 26 publications

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“…1. To practically exploit this physical principle, the geometry of the micro-optofluidic device has been appropriately determined, also thanks to the help of appropriate simulations reported in previous studies [27]. Briefly, the device has two inlets, necessary for the inlet of the two fluids characterizing the two-phase fluid to be studied, which are connected to the two micro-channels that, forming a T-junction, guarantee the formation of the two-phase slug flow.…”

Section: Micro-optofluidic Device Design and Working Principlementioning

confidence: 99%

“…In this study two devices, which differ each other for the fabrication process and the raw materials used, were compared. The first micro-optofluidic system (Device 1 ) was realized using PDMS with a fabrication process which has already been explained elsewhere in detail [27]. The fabrication procedure followed is summarized in Fig.…”

Section: Micro-optofluidic Devices Fabrication Processesmentioning

confidence: 99%

“…In this study, a low-cost portable device designed by the authors [27,28], was manufactured using PDMS for soft lithography and a photocurable resin for the PµSTL manufacturing technique. The 3D printed device was manufactured in one piece with no assembly using a one-step manufacturing.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Projection Micro Stereolithography (PµSL) to 3D Print a Micro-Optofluidic Device for Two-Phase Slug Flow Detection: a Comparison with a PDMS-Based Device Manufactured by Resin Casting

Saitta

Celano

Cicala

et al. 2021

Preprint

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In this work, the use of Projection Micro Stereolithography (PmSL) to 3D print a micro-optofluidic device for two-phase slug flow detection is presented. For comparison purposes a PDMS based device obtained by casting was also manufactured. The micro-optofluidic device has a microfluidic T-junction with a micro-optical section that consists of two optical fiber insertions used for two-phase slug flow detection. The working principle in the detection is based on a different light transmission correlated to the fluid interfering with the laser beam in a micro-channel section. The 3D printed material is fully characterized in terms of its surface properties and compared to PDMS used for standard construction using a master-slave casting procedure. The two devices were tested after the setup parameters for the detection were optimized using ANOVA for the 3D printed device. The comparisons of the two devices revealed that 3D printed device can be used for two-phase slug flow detection but future research is still need to obtain a 3D printed resin allowing to outperform PDMS.

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Section: Micro-optofluidic Device Design and Working Principlementioning

confidence: 99%

Section: Micro-optofluidic Devices Fabrication Processesmentioning

confidence: 99%

See 1 more Smart Citation

Projection Micro Stereolithography (PµSL) to 3D Print a Micro-Optofluidic Device for Two-Phase Slug Flow Detection: a Comparison with a PDMS-Based Device Manufactured by Resin Casting

Saitta

Celano

Cicala

et al. 2021

Preprint

Self Cite

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“…In this paper, two approaches based on low-cost technologies, 3D Printing PDMSbased and laser cutting PMMA-based, were investigated as novel methods to realize micro-optical waveguides suitable for integration in micro-optofluidics devices [21,22], comparing their performances. An ad-hoc master-slave protocol developed to realize PDMS components by 3DPrinting has been fully optimized.…”

Section: Introductionmentioning

confidence: 99%

Micro-Optical Waveguides Realization by Low-Cost Technologies

Cairone

Afflitto

Stella

et al. 2022

Micro

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Microscale optofluidic devices are a category of microscale devices combining fluidic and optical features. These devices typically enable in-situ fluid flow measurement for pharmaceutical, environmental or biomedical applications. In micro-optofluidic devices, in order to deliver, as close as possible, the input light to the sample or a specific chip section and, collect the output signal, it is necessary to miniaturize optical components. In this paper, two low-cost technologies, 3D Printing PDMS-based and laser cutting PMMA-based (PDMS stands for Poly-dimethyl-siloxane and PMMA for Poly-methyl-methacrylate), were investigated as novel methods to realize micro-optical waveguides (μWGs) comparing their performances. An ad-hoc master-slave protocol developed to realize PDMS components by 3D Printing has been fully optimized. The manufacturing technologies proposed require simple and low-cost equipment and no strictly controlled environment. Similar results are obtained for both the micro-optical waveguides realized. Their losses, disregarding the losses caused by the fibers’ alignment and the miss-match of the geometry with the waveguide, are of the order of 20%, almost equivalent for both approaches (PDMS-μWG and PMMA-μWG). The losses are of the order of 10% when the PDMS-μWG is shielded by a copper layer, with a significant improvement of the signal acquired. The results obtained show the possibility of using the two low-cost technologies presented for the realization of micro-optical waveguides suitable to be integrated in micro-optofluidic devices and the potential of creating micro-optical paths inside micro-embedded systems.

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“…This is a relevant point for application. In the literature there are increasing examples of the use of additive manufacturing in several fields ranging from microfluidics [11][12][13], tooling for composites [14,15] and injection molding [16]. Mixing epoxy blends with photocurable resins can open the field to novel formulation too if complex toughened epoxy blends area used [17,18] because this can be a suitable method to obtain the impact resistance of the printed specimens.…”

Section: Introductionmentioning

confidence: 99%

Epoxy Based Blends for Additive Manufacturing by Liquid Crystal Display (LCD) Printing: The Effect of Blending and Dual Curing on Daylight Curable Resins

et al. 2020

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Epoxy-based blends printable in a Liquid Crystal Display (LCD) printer were studied. Diglycidyl ether of bisphenol A (DGEBA) mixed with Diethyltoluene diamine (DETDA) was used due to the easy processing in liquid form at room temperature and slower reactivity until heated over 150 ° C. The DGEBA/DETDA resin was mixed with a commercial daylight photocurable resin used for LCD screen 3D printing. Calorimetric, dynamic mechanical and rheology testing were carried out on the resulting blends. The daylight resins showed to be thermally curable. Resin’s processability in the LCD printer was evaluated for all the blends by rheology and by 3D printing trials. The best printing conditions were determined by a speed cure test. The use of a thermal post-curing cycle after the standard photocuring in the LCD printer enhanced the glass transition temperature T g of the daylight resin from 45 to 137 ° C when post-curing temperatures up to 180 ° C were used. The T g reached a value of 174 ° C mixing 50 wt% of DGEBA/DETDA resin with the photocurable resin when high temperature cure cycle was used.

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3D-Printed micro-optofluidic device for chemical fluids and cells detection

Cited by 17 publications

References 26 publications

Projection Micro Stereolithography (PµSL) to 3D Print a Micro-Optofluidic Device for Two-Phase Slug Flow Detection: a Comparison with a PDMS-Based Device Manufactured by Resin Casting

Projection Micro Stereolithography (PµSL) to 3D Print a Micro-Optofluidic Device for Two-Phase Slug Flow Detection: a Comparison with a PDMS-Based Device Manufactured by Resin Casting

Micro-Optical Waveguides Realization by Low-Cost Technologies

Epoxy Based Blends for Additive Manufacturing by Liquid Crystal Display (LCD) Printing: The Effect of Blending and Dual Curing on Daylight Curable Resins

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