3D printed infliximab suppositories for rectal biologic delivery

Awad, Atheer; Goyanes, Álvaro; Orlu, Mine; Gaisford, Simon; Basit, Abdul W.

doi:10.1016/j.ijpx.2023.100176

Cited by 9 publications

(6 citation statements)

References 59 publications

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“…Recently, Awad et al fabricated infliximab (a monoclonal antibody) containing a suppository (shown in Figure 6 ) by 3D printing the SSE technique for rectal delivery for the treatment of inflammatory bowel disease [ 91 ]. It was observed that infliximab remains stable following the 3D printing process, and the GEL48W20 suppository disintegrated significantly faster ( p < 0.05) than the GEL48W7.5 suppository.…”

Section: 3d Printing Technology To Design Nanomedicine-based Solid Do...mentioning

confidence: 99%

“… Infliximab-containing suppositories (GEL48W7.5 [ left ]—composed of Gelucire 48/16, coconut oil, water, and infliximab; GEL48W20 [ right ]—composed of Gelucire 48/16, water, and infliximab) prepared by SSE-based 3D printing techniques for rectal delivery. Reproduced from Awad et al [ 91 ], copyright 2023, Elsevier. …”

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope

et al. 2023

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3D printing technology in medicine is gaining great attention from researchers since the FDA approved the first 3D-printed tablet (Spritam®) on the market. This technique permits the fabrication of various types of dosage forms with different geometries and designs. Its feasibility in the design of different types of pharmaceutical dosage forms is very promising for making quick prototypes because it is flexible and does not require expensive equipment or molds. However, the development of multi-functional drug delivery systems, specifically as solid dosage forms loaded with nanopharmaceuticals, has received attention in recent years, although it is challenging for formulators to convert them into a successful solid dosage form. The combination of nanotechnology with the 3D printing technique in the field of medicine has provided a platform to overcome the challenges associated with the fabrication of nanomedicine-based solid dosage forms. Therefore, the major focus of the present manuscript is to review the recent research developments that involved the formulation design of nanomedicine-based solid dosage forms utilizing 3D printing technology. Utilization of 3D printing techniques in the field of nanopharmaceuticals achieved the successful transformation of liquid polymeric nanocapsules and liquid self-nanoemulsifying drug delivery systems (SNEDDS) to solid dosage forms such as tablets and suppositories easily with customized doses as per the needs of the individual patient (personalized medicine). Furthermore, the present review also highlights the utility of extrusion-based 3D printing techniques (Pressure-Assisted Microsyringe—PAM; Fused Deposition Modeling—FDM) to produce tablets and suppositories containing polymeric nanocapsule systems and SNEDDS for oral and rectal administration. The manuscript critically analyzes contemporary research related to the impact of various process parameters on the performance of 3D-printed solid dosage forms.

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Section: 3d Printing Technology To Design Nanomedicine-based Solid Do...mentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope

et al. 2023

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“…Biologics are another class of drugs that are naturally derived by engineered biotechnological processes and are known for their complex and less stable structures. [165] They include hormones, cytokines, and peptides, and are used in the treatment of several human diseases such as cancer, [166] rheumatoid arthritis, [167,168] inflammatory bowel diseases, [169] and growth deficiencies. To allow higher control over the dose and release properties, IJP has been used to develop oromucosal films containing biologics.…”

Section: Oromucosal Filmsmentioning

confidence: 99%

Inkjet Printing of Pharmaceuticals

Carou‐Senra,

Rodríguez‐Pombo,

Awad

et al. 2023

Advanced Materials

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Inkjet printing (IJP) is an additive manufacturing process that selectively deposits ink materials, layer‐by‐layer, to create three‐dimensional (3D) objects or two‐dimensional (2D) patterns with precise control over their structure and composition. This technology has emerged as an attractive and versatile approach to address the ever‐evolving demands of personalized medicine in the healthcare industry. Although originally developed for non‐healthcare applications, IJP harnesses the potential of pharma‐inks, which are meticulously formulated inks containing drugs and pharmaceutical excipients. Delving into the formulation and components of pharma‐inks, the key to precise and adaptable material deposition enabled by IJP is unraveled. The review extends its focus to substrate materials, including paper, films, foams, lenses, and 3D‐printed materials, showcasing their diverse advantages, whilst exploring a wide spectrum of therapeutic applications. Additionally, the potential benefits of hardware and software improvements, along with artificial intelligence integration, are discussed to enhance IJP's precision and efficiency. Embracing these advancements, IJP holds immense potential to reshape traditional medicine manufacturing processes, ushering in the era of medical precision. However, further exploration and optimization are needed to fully utilize IJP's healthcare capabilities. As researchers push the boundaries of IJP, the vision of patient‐specific treatment is on the horizon of becoming a tangible reality.This article is protected by copyright. All rights reserved

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“…Semi-solid extrusion (SSE) is a material extrusion technique, depositing gels, waxes, or pastes to create solid objects without requiring high temperatures, thereby preventing drug degradation and ensuring rapid, low-temperature printing [90]. SSE has facilitated the development of tailored 3D printed dosage forms (termed printlets) and drug delivery systems such as orodispersible printlets [91][92][93][94][95], polypills (i.e., multidrug-loaded printlets) [88,96,97], suppositories [98][99][100][101], immediate [102,103] and controlled release tablets [104,105], microneedles [106], intravesical inserts [107], or ophthalmologic [108] and dermal [109] patches (Figure 5). Semi-solid extrusion (SSE) is a material extrusion technique, depositing gels, waxes, or pastes to create solid objects without requiring high temperatures, thereby preventing drug degradation and ensuring rapid, low-temperature printing [90].…”

Section: Advanced Therapies Through 3d Printing Technologymentioning

confidence: 99%

3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in Pediatric Populations

Carou-Senra,

Rodríguez-Pombo,

Monteagudo-Vilavedra

et al. 2023

Nutrients

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The incidence of Inborn Error of Intermediary Metabolism (IEiM) diseases may be low, yet collectively, they impact approximately 6–10% of the global population, primarily affecting children. Precise treatment doses and strict adherence to prescribed diet and pharmacological treatment regimens are imperative to avert metabolic disturbances in patients. However, the existing dietary and pharmacological products suffer from poor palatability, posing challenges to patient adherence. Furthermore, frequent dose adjustments contingent on age and drug blood levels further complicate treatment. Semi-solid extrusion (SSE) 3D printing technology is currently under assessment as a pioneering method for crafting customized chewable dosage forms, surmounting the primary limitations prevalent in present therapies. This method offers a spectrum of advantages, including the flexibility to tailor patient-specific doses, excipients, and organoleptic properties. These elements are pivotal in ensuring the treatment’s efficacy, safety, and adherence. This comprehensive review presents the current landscape of available dietary products, diagnostic methods, therapeutic monitoring, and the latest advancements in SSE technology. It highlights the rationale underpinning their adoption while addressing regulatory aspects imperative for their seamless integration into clinical practice.

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3D printed infliximab suppositories for rectal biologic delivery

Cited by 9 publications

References 59 publications

3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope

3D Printing Technology as a Promising Tool to Design Nanomedicine-Based Solid Dosage Forms: Contemporary Research and Future Scope

Inkjet Printing of Pharmaceuticals

3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in Pediatric Populations

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