3D-Printed Hydrogel for Diverse Applications: A Review

Agrawal, Arpana; Hussain, Chaudhery Mustansar

doi:10.3390/gels9120960

Cited by 13 publications

(13 citation statements)

References 140 publications

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“…This is a challenge in 3D bioprinting research that most studies of the current literature lacks. Printing of intricate scaffold architectures can help to design hierarchical formulations and structures ( Agrawal and Hussain, 2023 ) that optimizes scalability and can lead to new in situ print applications ( Zhao et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate

Grandjean,

Perumal,

Manicam

et al. 2024

Front. Bioeng. Biotechnol.

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Introduction:Autologous platelet concentrate (APC) are pro-angiogenic and can promote wound healing and tissue repair, also in combination with other biomaterials. However, challenging defect situations remain demanding. 3D bioprinting of an APC based bioink encapsulated in a hydrogel could overcome this limitation with enhanced physio-mechanical interface, growth factor retention/secretion and defect-personalized shape to ultimately enhance regeneration.Methods:This study used extrusion-based bioprinting to create a novel bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate. Chemico-physical testing exhibited an amorphous structure characterized by high shape fidelity. Cytotoxicity assay and incubation of human osteogenic sarcoma cells (SaOs2) exposed excellent biocompatibility. enzyme-linked immunosorbent assay analysis confirmed pro-angiogenic growth factor release of the printed constructs, and co-incubation with HUVECS displayed proper cell viability and proliferation. Chorioallantoic membrane (CAM) assay explored the pro-angiogenic potential of the prints in vivo. Detailed proteome and secretome analysis revealed a substantial amount and homologous presence of pro-angiogenic proteins in the 3D construct.Results:This study demonstrated a 3D bioprinting approach to fabricate a novel bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate with high shape fidelity, biocompatibility, and substantial pro-angiogenic properties.Conclusion:This approach may be suitable for challenging physiological and anatomical defect situations when translated into clinical use.

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Section: Discussionmentioning

confidence: 99%

Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate

Grandjean,

Perumal,

Manicam

et al. 2024

Front. Bioeng. Biotechnol.

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“…Thus, it does not require the use of specific equipment, which is used in the method of using particular hydrogel compositions as ink for 3D photoprinting of biologically active hydrogel materials [23] and does not include the stage of post-processing of annual products [24].…”

Section: Discussionmentioning

confidence: 99%

Modeling of Smart Bio-Medical Active Polymeric Hydrogel Transdermal Materials

Lebedeva,

Cherkashina,

Masikevych

et al. 2024

JES

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In this article, effective 3D printing modeling technology of smart bio-medical polymeric hydrogel transdermal materials based on gelatin and sodium alginate, modified by humic acids, was researched. Such smart biologically active polymeric hydrogel materials showed interesting applicability in tissue engineering fields due to their intrinsic biological compatibility, adaptability, and capacity to replicate the extracellular matrix environment. A literature review was carried out and proved that 3D printing modeling technology is a perspective for the functional effect on the smart bio-medical polymer hydrogel transdermal properties. Smart biomedical polymeric transdermal hydrogel patches were produced using a micromolding technique. A stereolithography (SLA) 3D printer was used to print the master mold. The three-stage technology of lignite humic acids modification of smart biologically active polymeric hydrogel transdermal microneedles patches based on gelatin, hydroxypropyl methylcellulose, and sodium alginate was designed. It was shown that modification of gelatin-sodium alginate and hydroxypropyl methylcellulose-sodium alginate biopolymer hydrogels by humic acids makes it possible to obtain smart biologically active polymeric hydrogel transdermal materials with an increased swelling degree and ability to improve the skin moisture-lipid balance (from the initial moisture 34–36 % and fatness 8–10, they increase to 58–66 % and 52–60 %). Finally, the developed 3D printing modeling technology of smart bio-medical polymeric hydrogel transdermal materials hydrogel based on gelatin sodium alginate, modified by humic acids, is a transdermal material with required properties.

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“…The fabrication techniques employed for self-healing hydrogels encompass a spectrum of methodologies, spanning physical blending, chemical reactions, and advanced methodologies like 3D printing, offering precise control over the hydrogel's structure and attributes [362].…”

Section: Clinical Applications Of Regenerative Hydrogelsmentioning

confidence: 99%

“…Self-healing hydrogels have demonstrated various applications in therapeutic domains [360,[362][363][364][365]:…”

Section: Clinical Applications Of Regenerative Hydrogelsmentioning

confidence: 99%

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

Olteanu,

Neacșu,

Joița

et al. 2024

IJMS

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This state-of-the-art review explores the emerging field of regenerative hydrogels and their profound impact on the treatment of skin wounds. Regenerative hydrogels, composed mainly of water-absorbing polymers, have garnered attention in wound healing, particularly for skin wounds. Their unique properties make them well suited for tissue regeneration. Notable benefits include excellent water retention, creating a crucially moist wound environment for optimal healing, and facilitating cell migration, and proliferation. Biocompatibility is a key feature, minimizing adverse reactions and promoting the natural healing process. Acting as a supportive scaffold for cell growth, hydrogels mimic the extracellular matrix, aiding the attachment and proliferation of cells like fibroblasts and keratinocytes. Engineered for controlled drug release, hydrogels enhance wound healing by promoting angiogenesis, reducing inflammation, and preventing infection. The demonstrated acceleration of the wound healing process, particularly beneficial for chronic or impaired healing wounds, adds to their appeal. Easy application and conformity to various wound shapes make hydrogels practical, including in irregular or challenging areas. Scar minimization through tissue regeneration is crucial, especially in cosmetic and functional regions. Hydrogels contribute to pain management by creating a protective barrier, reducing friction, and fostering a soothing environment. Some hydrogels, with inherent antimicrobial properties, aid in infection prevention, which is a crucial aspect of successful wound healing. Their flexibility and ability to conform to wound contours ensure optimal tissue contact, enhancing overall treatment effectiveness. In summary, regenerative hydrogels present a promising approach for improving skin wound healing outcomes across diverse clinical scenarios. This review provides a comprehensive analysis of the benefits, mechanisms, and challenges associated with the use of regenerative hydrogels in the treatment of skin wounds. In this review, the authors likely delve into the application of rational design principles to enhance the efficacy and performance of hydrogels in promoting wound healing. Through an exploration of various methodologies and approaches, this paper is poised to highlight how these principles have been instrumental in refining the design of hydrogels, potentially revolutionizing their therapeutic potential in addressing skin wounds. By synthesizing current knowledge and highlighting potential avenues for future research, this review aims to contribute to the advancement of regenerative medicine and ultimately improve clinical outcomes for patients with skin wounds.

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3D-Printed Hydrogel for Diverse Applications: A Review

Cited by 13 publications

References 140 publications

Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate

Towards optimized tissue regeneration: a new 3D printable bioink of alginate/cellulose hydrogel loaded with thrombocyte concentrate

Modeling of Smart Bio-Medical Active Polymeric Hydrogel Transdermal Materials

Advancements in Regenerative Hydrogels in Skin Wound Treatment: A Comprehensive Review

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