3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study

Korean Amberjack Skin-Inspired Hyaluronic Acid Bioink for Reconstruction of Human Skin

“…In the cases of HA/0dECM and HA/10dECM, which contained a higher amount of HA, a larger proportion of HA was crosslinked when increasing the DVS ratio and this caused a greater decrease of the swelling ratio of these scaffolds. The highest swelling ratio of the HA/30dECM scaffold could be because of the swelling properties of collagen fibers presented in dECM . A previous study on 3D gelatin/dECM-based bioink reported that the 3D-printed model with the highest ratio of dECM showed the highest change in weight after incubation in the cell culture medium .…”

“…The highest swelling ratio of the HA/30dECM scaffold could be because of the swelling properties of collagen fibers presented in dECM . A previous study on 3D gelatin/dECM-based bioink reported that the 3D-printed model with the highest ratio of dECM showed the highest change in weight after incubation in the cell culture medium . A DVS ratio of 7% (v/v) was used for further experiments to maintain suitable swelling properties for wound healing effects.…”

Gelatin as It Is: History and Modernity

“…Of natural compounds, chitin and chitosan [ 209 , 210 , 211 , 212 , 213 ], silk [ 214 , 215 , 216 ], and hyaluronan [ 217 , 218 , 219 , 220 , 221 , 222 , 223 ] are mentioned in the literature; among synthetic compounds, this included poly(lactic-co-glycolic) acid [ 224 , 225 , 226 , 227 , 228 , 229 ], oligo(poly(ethylene glycol) fumarate [ 230 , 231 , 232 , 233 , 234 , 235 , 236 ] and poly(propylene) fumarate [ 237 , 238 , 239 , 240 , 241 , 242 ]. Of the recent works, it should be noted that publications [ 243 , 244 , 245 , 246 , 247 , 248 , 249 , 250 , 251 , 252 , 253 ], along with the named components of gelatin systems, also used some other polymers, for example, methacrylate [ 244 ], polycaprolactone [ 246 ], and polypyrrole [ 248 ]. To the use of these polymers in medical practice, a review [ 253 ] was devoted.…”

Tackling current production of HAp and HAp-driven biomaterials

“…The addition of HAp derivatives to the gelatin scaffold, as observed in other soft biocomposites such as alginate, has been shown to promote cell osteogenesis through increased expression of osteogenic genes and inorganic matrix deposition. 203 In the present study, gelatin was combined with decellularized bone particles (dbPTs, B100 mm diameter) to produce 3D printed scaffolds. These scaffolds were further subjected to freeze-drying, and the obtained results revealed a decrease in pore size with an increase in HAp concentration (Fig.…”

“…Fig.7Gelatin/dbPTs 3D printed scaffolds 203. (A) Morphological analysis of the Gelatin/dbPTs 3D printed scaffolds.…”