3D-printed fluidic devices enable quantitative evaluation of blood components in modified storage solutions for use in transfusion medicine

Chen, Chengpeng; Wang, Yimeng; Lockwood, Sarah Y.; Spence, Dana M.

doi:10.1039/c3an02357e

Cited by 72 publications

(64 citation statements)

References 26 publications

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“…Since its invention in the late 1980s, 3D printing offers the opportunity for manufacturers to circumvent the time-consuming steps of traditional manufacturing technology via a full-scale or scaled-down mechanical replica of the products designed by computers [46][47][48][49]. A broad range of research components, including chemical reaction-ware [40,44,48,50], gradient generators [51,52], instrumental setups and interfaces [53][54][55][56][57], droplet extractors [52], and user-oriented functional devices [58][59][60][61] have been successfully built with the aid of 3D printing technologies confirming the feasibility of this approach. Further modification of 3D printed devices via adding chemicals or precursors of interest or post-printing surface functionalization extend the applicability of constructed products [45,62,63].…”

Section: D Printing Technologiesmentioning

confidence: 99%

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

Zhang

2016

TrAC Trends in Analytical Chemistry

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Section: D Printing Technologiesmentioning

confidence: 99%

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

Zhang

2016

TrAC Trends in Analytical Chemistry

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“…36,37 In some studies, fluidic devices were designed so that the positions of membrane inserts and measurement reservoirs enabled analyses to be performed by a commercial plate reader (Figure 3). 37 …”

Section: 3d-printed Fluidic Devicesmentioning

confidence: 99%

3D-printed bioanalytical devices

et al. 2016

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While 3D printing technologies first appeared in the 1980s, prohibitive costs, limited materials, and the relatively small number of commercially available printers confined applications mainly to prototyping for manufacturing purposes. As technologies, printer cost, materials, and accessibility continue to improve, 3D printing has found widespread implementation in research and development in many disciplines due to ease-of-use and relatively fast design-to-object workflow. Several 3D printing techniques have been used to prepare devices such as milli- and microfluidic flow cells for analyses of cells and biomolecules as well as interfaces that enable bioanalytical measurements using cellphones. This review focuses on preparation and applications of 3D-printed bioanalytical devices.

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“…28 Spence and colleagues, who were the first to describe the use of 3D-printing to fabricate microfluidic systems, have shown that the resulting devices can be easily integrated with other commercial instruments, such as a microplate reader. 3, 29, 30 Compared to glass or PDMS-based microfluidic devices; 3D-printing enables the fabrication of device in one step, without bonding several components together. These reported 3D-printed devices are also reusable and the CAD drawing can be easily shared between laboratories, increasing reproducibility between analysts and laboratories.…”

Section: Introductionmentioning

confidence: 99%

Microchip-based electrochemical detection using a 3-D printed wall-jet electrode device

Munshi

Martin

2016

Analyst

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Three dimensional (3-D) printing technology has evolved dramatically in the last few years, offering the capability of printing objects with a variety of materials. Printing microfluidic devices using this technology offers various advantages such as ease and uniformity of fabrication, file sharing between laboratories, and increased device-to-device reproducibility. One unique aspects of this technology, when used with electrochemical detection, is the ability to produce a microfluidic device as one unit while also allowing the reuse of the device and electrode for multiple analyses. Here we present an alternate electrode configuration for microfluidic devices, a wall-jet electrode (WJE) approach, created by 3-D printing. Using microchip-based flow injection analysis, we compared the WJE design with the conventionally used thin-layer electrode (TLE) design. It was found that the optimized WJE system enhances analytical performance (as compared to the TLE design), with improvements in sensitivity and the limit of detection. Experiments were conducted using two working electrodes – 500 μm platinum and 1 mm glassy carbon. Using the 500 μm platinum electrode the calibration sensitivity was 16 times higher for the WJE device (as compared to the TLE design). In addition, use of the 1 mm glassy carbon electrode led to limit of detection of 500 nM for catechol, as compared to 6 μM for the TLE device. Finally, to demonstrate the versatility and applicability of the 3-D printed WJE approach, the device was used as an inexpensive electrochemical detector for HPLC. The number of theoretical plates was comparable to the use of commercially available UV and MS detectors, with the WJE device being inexpensive to utilize. These results show that 3D-printing can be a powerful tool to fabricate reusable and integrated microfluidic detectors in configurations that are not easily achieved with more traditional lithographic methods.

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3D-printed fluidic devices enable quantitative evaluation of blood components in modified storage solutions for use in transfusion medicine

Abstract: A fluidic device constructed with a 3D-printer can be used to investigate stored blood components with subsequent high-throughput calibration and readout with a standard plate reader.

Cited by 72 publications

References 26 publications

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

Chemical and biochemical analysis on lab-on-a-chip devices fabricated using three-dimensional printing

3D-printed bioanalytical devices

Microchip-based electrochemical detection using a 3-D printed wall-jet electrode device

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