3D-printed flexible polymer stents for potential applications in inoperable esophageal malignancies

Lin, Maohua; Firoozi, Negar; Tsai, Chi-Tay; Wallace, Michael B.; Kang, Yunqing

doi:10.1016/j.actbio.2018.10.035

Cited by 68 publications

(52 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the last few years, tissue engineering (TE) has emerged as a promising solution for the replacement of physiological esophageal functions [7][8][9]. This field of science has deeply benefited from meaningful progresses in biomaterial science, nanotechnologies, bioreactor technology, molecular biology, and stem cells discovery [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, the issue related to rejection or host immune response activation has been mitigated producing scaffold based on biocompatible and absorbable polymers. The research in this area is very dynamic, having a high interest in finding multidisciplinary approaches for solving transplant issues [8,[14][15][16][17][18][19] Several cutting-edge technologies have been exploited in the last years, such as electrospinning, 3D printing, and 3D bioprinting, for producing biodegradable and biocompatible scaffolds having structures that resemble the natural extracellular matrix (ECM). The electrospinning is a fabrication technology based on high electric fields that can be used to produce fibers ranging from the submicron to nanometers size.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tissue Engineered Esophageal Patch by Mesenchymal Stromal Cells: Optimization of Electrospun Patch Engineering

Pisani

Croce

Chiesa

et al. 2020

IJMS

View full text Add to dashboard Cite

Aim of work was to locate a simple, reproducible protocol for uniform seeding and optimal cellularization of biodegradable patch minimizing the risk of structural damages of patch and its contamination in long-term culture. Two seeding procedures are exploited, namely static seeding procedures on biodegradable and biocompatible patches incubated as free floating (floating conditions) or supported by CellCrownTM insert (fixed conditions) and engineered by porcine bone marrow MSCs (p-MSCs). Scaffold prototypes having specific structural features with regard to pore size, pore orientation, porosity, and pore distribution were produced using two different techniques, such as temperature-induced precipitation method and electrospinning technology. The investigation on different prototypes allowed achieving several implementations in terms of cell distribution uniformity, seeding efficiency, and cellularization timing. The cell seeding protocol in stating conditions demonstrated to be the most suitable method, as these conditions successfully improved the cellularization of polymeric patches. Furthermore, the investigation provided interesting information on patches’ stability in physiological simulating experimental conditions. Considering the in vitro results, it can be stated that the in vitro protocol proposed for patches cellularization is suitable to achieve homogeneous and complete cellularizations of patch. Moreover, the protocol turned out to be simple, repeatable, and reproducible.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tissue Engineered Esophageal Patch by Mesenchymal Stromal Cells: Optimization of Electrospun Patch Engineering

Pisani

Croce

Chiesa

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Cell spheroids with human dermal fibroblasts, human esophageal smooth muscle cells, human bone marrow-derived mesenchymal stem cells, human umbilical vein endothelial cells [115] Rod supporting bioprinting and electrospinning Polyurethane (PU), polycaprolactone (PCL) [15] Rod supporting bioprinting and electrospinning Polycaprolactone (PCL) [14] Direct bioprinting Thermal polyurethane (TPU), polylactic acid (PLA) [130] Yosuke Takeoka et al developed a scaffold-free biomimetic structure for the regeneration of the esophagus using the kenzan method bioprinting (Figure 3) [115]. This team used the maturated cell spheroids of the normal human dermal fibroblasts (NHDFs), human esophageal smooth muscle cells (HESMCs), human bone marrow-derived mesenchymal stem cells (MSCs), and human umbilical vein endothelial cells (HUVECs) to print the tubular multicellular structures.…”

Section: Kenzan Methods Bioprintingmentioning

confidence: 99%

“…Among the mechanical stimuli, in particular, the intermittent shear flow by hydrostatic pressure and the shear stress by flow media were relevant to improving efficacy for differentiation of the epithelial and muscle lineage compared to steady shear flow. Direct bioprinting Thermal polyurethane (TPU), polylactic acid (PLA) [130] Similarly, Eun-Jae Chung et al utilized both supporting rod bioprinting and electrospinning and developed an esophageal scaffold reinforced by a 3D-printed PCL ring [14]. After bioprinting the reinforcing ring on the rod, a thin PCL layer was formed by electrospinning to form a nano-structured In Gul Kim et al employed both techniques of the supporting rod bioprinting and electrospinning to build the enhanced tubular structure with two-layer [15].…”

Section: Kenzan Methods Bioprintingmentioning

confidence: 99%

“…Maohua Lin et al used direct bioprinting to a fabricated esophageal tubular stent with spiral patterns that applied the optimized design by computational simulation [130]. The printed esophageal tubular stent consisted of a mixed biodegradable polymer of medical-grade thermal polyurethane (TPU) and PLA in optimum proportion to achieve appropriate mechanical stiffness and flexibility.…”

Section: Kenzan Methods Bioprintingmentioning

confidence: 99%

See 1 more Smart Citation

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

et al. 2020

View full text Add to dashboard Cite

It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-shaped tissues and organs have their own design with target-specific mechanical and biological properties. Therefore, the customized geometrical and physiological environment is required as one of the most critical factors for functional tissue regeneration. 3D bioprinting technology has been receiving attention for the fabrication of patient-tailored and complex-shaped free-form architecture with high reproducibility and versatility. Printable biocomposite inks that can facilitate to build tissue constructs with polymeric frameworks and biochemical microenvironmental cues are also being actively developed for the reconstruction of functional tissue. In this review, we delineated the state-of-the-art of 3D bioprinting techniques specifically for tubular tissue and organ regeneration. In addition, this review described biocomposite inks, such as natural and synthetic polymers. Several described engineering approaches using 3D bioprinting techniques and biocomposite inks may offer beneficial characteristics for the physiological mimicry of human tubular tissues and organs.

show abstract

4D‐Printed Biodegradable and Remotely Controllable Shape Memory Occlusion Devices

Lin

et al. 2019

Adv Funct Materials

195

143

View full text Add to dashboard Cite

Implantation of occlusion devices is an effective approach for the treatment of congenital heart diseases in the clinic. However, most commercial clinical occlusion devices are currently made of nondegradable metals, which may lead to complications such as perforation, allergies, and erosion. In this work, 4D-printed novel, biodegradable, remotely controllable, and personalized shape memory occlusion devices are demonstrated and atrial septal defect occluders are exemplified. By incorporating Fe 3 O 4 magnetic particles into the shape memory poly(lactic acid) matrix, the deployment of the occluders can be controlled remotely after implantation. The excellent cytocompatibility and histocompatibility are conducive to cell adhesion and ingrowth of granulation tissues into the occluders, thus facilitating rapid endothelialization. In addition, personalized shape memory occluders ensure an ideal fit and provide sufficient support for defects. Therefore, 4D-printed shape memory occluders can be used as a potential substitute for metal occlusion devices.

show abstract

3D-printed flexible polymer stents for potential applications in inoperable esophageal malignancies

Cited by 68 publications

References 50 publications

Tissue Engineered Esophageal Patch by Mesenchymal Stromal Cells: Optimization of Electrospun Patch Engineering

Tissue Engineered Esophageal Patch by Mesenchymal Stromal Cells: Optimization of Electrospun Patch Engineering

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

4D‐Printed Biodegradable and Remotely Controllable Shape Memory Occlusion Devices

Contact Info

Product

Resources

About