3D-printed electrochemical glucose device with integrated Fe(II)-MOF nanozyme

Koukouviti, Eleni; Plessas, Alexios K.; Pagkali, Varvara; Economou, Anastasios; Papaefstathìou, Giannis S.; Kokkinos, Christos

doi:10.1007/s00604-023-05860-6

Cited by 7 publications

(1 citation statement)

References 39 publications

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“…16 Moreover, Koukouvit et al investigated a 3D-printed Fe( ii ) MOF-based nanozyme for the electrochemical detection of glucose. 17 However, although these 3D-printed substrates are polymer- and plastic-based, which are mostly disposable and difficult to recycle. Thus, considering this, we developed DEG 500 nanozyme-deposited 3D-printed metal substates (alloy of Ti, V and Al) for portable application and reusability.…”

Section: Introductionmentioning

confidence: 99%

Immobilizing nanozymes on 3D-printed metal substrates for enhanced peroxidase-like activity and trace-level glucose detection

Koley,

Jakku,

Hosseinnejad

et al. 2024

Nanoscale

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Section: Introductionmentioning

confidence: 99%

Immobilizing nanozymes on 3D-printed metal substrates for enhanced peroxidase-like activity and trace-level glucose detection

Koley,

Jakku,

Hosseinnejad

et al. 2024

Nanoscale

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3D Printable Multifunctional Electrochemical Nano‐Doped Biofilament

Koukouviti,

Economou,

Kokkinos

2024

Adv Funct Materials

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Fused deposition modeling (FDM) represents a state‐of‐the‐art 3D printing technology that holds great promise in the field of electrochemistry as a fast, in‐house, and digital fabrication method of sustainable sensors. Despite the progress in FDM, existing practical 3D printed sensors still require post‐printing treatment to improve their operational features, either through (electro)chemical surface activation or surface modification with external functional materials. Herein, a novel lab‐made conductive biofilament with integrated two different types of metallic nanoparticles (NPs) for the 3D printing of ready‐to‐use and multiplexed electrochemical sensors is introduced. The filament is composed of biodegradable polylactic acid as a base, polyethylene glycol dimethyl ether as a plasticizer, carbon black as a conductive filler, and nanopowder oxides of bismuth and copper as integrated functional precursor materials. The as‐printed sensors serve as multifunctional transducers for the direct and sensitive determinations of several analytes, by exploiting the different properties of the two co‐existing NPs. Particularly, heavy metals (such as lead, and cadmium) are voltammetrically quantified by amalgamation with BiNPs electrogenerated from Bi2O3, while biomarkers (such as glucose, and uric acid) are determined in enzymatic‐free modes. Determination of glucose takes advantage of the electrocatalytic properties of CuO, while uric acid is directly oxidized at the sensor.

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An efficient enzyme cascade bio‐platform based on metal‐organic frameworks nanozyme for the detection of glucose

Sang

2023

J Chinese Chemical Soc

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ObjectiveEnzyme cascade reaction typically involves the synergistic action of two or more enzymes. It is an efficient tool in the field of biosensing. In this research, with the combination of natural enzyme and nanozyme, a high‐performance enzyme cascade bio‐platform is constructed for sensing of H2O2 and glucose.MethodsThe enzyme cascade bio‐platform consisting of natural enzyme glucose oxidase (GOX) and nanozyme (hemin@ZIF‐8) was constructed through one‐step co‐precipitation method. The morphology and structure of the composites were characterized by using scanning electron microscopy, x‐ray diffraction and Fourier transform infrared spectrometer. UV‐vis spectrophotometer was used to research the catalytic activity and sensing performances of enzyme cascade bio‐platform.ResultsThe synergistic catalysis between hemin and ZIF‐8 in hemin@ZIF‐8 nanozyme resulted in highly efficient peroxidase‐like activity, which could be used for H2O2 sensing. The porous structure of the metal‐organic framework provided a good microenvironment for loading the natural enzyme, guaranteeing the enzyme activity and spatial proximity of enzymes. The bio‐platform achieved the sensitive detection of glucose with low detection limit of 7.15 μM. Due to the color change in the catalytic reaction, this bio‐platform can be used for detecting glucose qualitatively and semi‐quantitatively with the naked eye.ConclusionsThe constructed efficient enzyme cascade bio‐platform combined the advantages of natural enzyme and nanozyme. This research not only expanded the application possibilities of nanozyme‐based enzyme cascade system, but also offered an effective strategy for the development of simple, rapid and reliable sensing methods for real application.

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3D-printed electrochemical glucose device with integrated Fe(II)-MOF nanozyme

Cited by 7 publications

References 39 publications

Immobilizing nanozymes on 3D-printed metal substrates for enhanced peroxidase-like activity and trace-level glucose detection

Immobilizing nanozymes on 3D-printed metal substrates for enhanced peroxidase-like activity and trace-level glucose detection

3D Printable Multifunctional Electrochemical Nano‐Doped Biofilament

An efficient enzyme cascade bio‐platform based on metal‐organic frameworks nanozyme for the detection of glucose

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