3D printed, controlled release, tritherapeutic tablet matrix for advanced anti-HIV-1 drug delivery

Siyawamwaya, Margaret; Toit, Lisa C. du; Kumar, Pradeep; Choonara, Yahya E.; Kondiah, Pierre P. D.; Pillay, Viness

doi:10.1016/j.ejpb.2018.04.007

Cited by 56 publications

(13 citation statements)

References 46 publications

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“…Chemically, emtricitabine (ECT) is 5-fluoro-1-(2R,5S)- [2-(hydroxymethyl It is a potential inhibitor of human immunodeficiency virus type I (HIV-I) reverse transcriptase and, hence, found to be effective against HIV-I infected patients [1,3]. ECT is prescribed to treat HIV-I infected patients either alone or in combination with other antiviral agents [3][4][5]. ECT is marketed It is a potential inhibitor of human immunodeficiency virus type I (HIV-I) reverse transcriptase and, hence, found to be effective against HIV-I infected patients [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…The potential of PEG-400 has been studied extensively in solubility enhancement of various drugs [9][10][11][12][13][14][15][16][17][18]. Several formulation approaches including "3D printed controlled release tablets [4], film coated tablets [19], rapidly disintegrating vaginal tablets [20], immediate release tablets [21], vaginal gels [22], liposomal gels [23], microparticulate drug delivery system [24], nanosuspensions [25,26] and polymeric nanoparticles [5,27,28]" were reported to improve antiviral therapy and pharmacokinetic profile of ECT. The equilibrium solubility of ECT in water was found as 112 mg mL −1 at "T = 298.2 K" [1].…”

Section: Introductionmentioning

confidence: 99%

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Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics

2020

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This study was aimed to find out the solubility, thermodynamic behavior, Hansen solubility parameters and molecular interactions of an antiviral drug emtricitabine (ECT) in various “[polyethylene glycol-400 (PEG-400) + water]” mixtures. The solubility of ECT in mole fraction was determined at “T = 298.2 to 318.2 K” and “p = 0.1 MPa” using an isothermal method. The experimental solubilities of ECT in mole fraction were validated and correlated using various computational models which includes “Van’t Hoff, Apelblat, Yalkowsky-Roseman, Jouyban-Acree and Jouyban-Acree-Van’t Hoff models”. All the models performed well in terms of model correlation. The solubility of ECT was increased with the raise in temperature in all “PEG-400 + water” mixtures studied. The highest and lowest solubility values of ECT were found in pure PEG-400 (1.45 × 10−1) at “T = 318.2 K” and pure water (7.95 × 10−3) at “T = 298.2 K”, respectively. The quantitative values of activity coefficients indicated higher interactions at molecular level in ECT and PEG-400 combination compared with ECT and water combination. “Apparent thermodynamic analysis” showed an “endothermic and entropy-driven dissolution” of ECT in all “PEG-400 + water” combinations studied. The solvation nature of ECT was found an “enthalpy-driven” in each “PEG-400 + water” mixture studied.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics

2020

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“…El Aita et al investigated the drying process and found only 3 h of drying at 200 mbar in a vacuum dryer was sufficient for the complete drying (loss on drying, LOD, <1%) of their printed structure [148]. Other drying conditions reported as using a vacuum dryer at 40 • C for 24 h [18,76,139], on the heated printing platform at 80 • C for 3 h [149], in an oven at 40 • C for 12 h [150,151], left at 20 • C for 12 h [152], in an incubator containing a silica gel bead cartridge at 40 • C for 24 h [63] etc. Drying effect on structure and properties of the finished products are reported as during the drying process shell formation may occur on the outer surface of the tablet which might cause inefficient drying and result in the mechanical properties (friability, hardness) of the tablet [148], deformation of the structure [63,76,150], formation of pores on the surface [152], paste shrinkage [139], etc.…”

Section: Dosage Shape Size Complexitymentioning

confidence: 99%

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

et al. 2020

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Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion-based (both fused deposition modeling (FDM) and pressure-assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion-based 3D printing of pharmaceuticals and how their properties, as well as the behavior of polymer–active pharmaceutical ingredient (API) combinations, impact the printing process. Especially, understanding the rheology of the polymer and API–polymer mixtures is necessary for successful 3D printing of dosage forms or printed structures. This review has summarized a holistic materials–process perspective for polymers on extrusion-based 3D printing. The main focus herein will be both FDM and PAM 3D printing processes. It elaborates the discussion on the comparison of 3D printing with the traditional direct compression process, the necessity of rheology, and the characterization techniques required for the printed structure, drug, and excipients. The current technological challenges, regulatory aspects, and the direction toward which the technology is moving, especially for personalized pharmaceuticals and multi-drug printing, are also briefly discussed.

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“…Pierre Kondiah (University of the Witwatersrand, Johannesburg, South Africa) presented the significance of personalized 3D printed oral tablets for overcoming the limitations of conventional tablet fabrication approaches, as well as specifically tailoring drug delivery particularly where a patient response to the same drugs is varied [69][70][71][72]. 3D printing is rapidly forging its niche as an advanced and transformative build technology holding significant application in pharmaceutical sciences for creating bioinspired solid 3D devices from a digital model with customizable, complex shapes, surfaces, and architectures employing diverse materials.…”

Section: Bioprintingmentioning

confidence: 99%

“…The addition of anti-inflammatory agents to the 3D bioink scaffolds provides acute treatment of specific inflammation and support for adequate tissue repair and rehabilitation. The specific prepared scaffold, PCL-PVA-PAA (PPP), experienced load bearing tissue repair where inflammation was prevalent [70].…”

Section: Bioprintingmentioning

confidence: 99%

Advances in Translational Nanotechnology: Challenges and Opportunities

et al. 2020

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The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area of research and development in the US and globally. NanoFlorida was founded to create a forum for scientific exchange, promote networking among nanoscientists, encourage collaborative research efforts across institutions, forge strong industry-academia partnerships in nanoscience, and showcase the contributions of students and trainees in nanotechnology fields. The 2019 NanoFlorida International Conference expanded this vision to emphasize national and international participation, with a focus on advances made in translating nanotechnology. This review highlights notable research in the areas of engineering especially in optics, photonics and plasmonics and electronics; biomedical devices, nano-biotechnology, nanotherapeutics including both experimental nanotherapies and nanovaccines; nano-diagnostics and -theranostics; nano-enabled drug discovery platforms; tissue engineering, bioprinting, and environmental nanotechnology, as well as challenges and directions for future research.

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3D printed, controlled release, tritherapeutic tablet matrix for advanced anti-HIV-1 drug delivery

Cited by 56 publications

References 46 publications

Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics

Solubility, Hansen Solubility Parameters and Thermodynamic Behavior of Emtricitabine in Various (Polyethylene Glycol-400 + Water) Mixtures: Computational Modeling and Thermodynamics

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective

Advances in Translational Nanotechnology: Challenges and Opportunities

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