3D printed biomedical devices and their applications: A review on state-of-the-art technologies, existing challenges, and future perspectives

Mamo, Hana Beyene; Adamiak, M.; Kunwar, Anil

doi:10.1016/j.jmbbm.2023.105930

Cited by 33 publications

(19 citation statements)

References 104 publications

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“…[ 210–216 ] Additionally, the lack of intelligent filaments has made the FDM process largely complex for the 4D printing. [ 217–220 ]…”

Section: Am Techniquesmentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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“…[ 210–216 ] Additionally, the lack of intelligent filaments has made the FDM process largely complex for the 4D printing. [ 217–220 ]…”

Section: Am Techniquesmentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

View full text Add to dashboard Cite

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“…3a Costs and time-consuming production in addition to the learning curve for design and implantation could be portrayed as the main limitations of utilization of these breakthrough instruments. 4a However, recent technological advancements in modeling and 3D printing may alleviate these limitations.…”

Section: Commentsmentioning

confidence: 99%

Rapid Implementation of a 3-Dimensional–Printed Patient-Specific Titanium Sacrum Implant for Severe Neuropathic Spinal Arthropathy and Guide to Compassionate US Regulatory Approval

Ruiz-Cardozo,

Trevino,

Pando

et al. 2023

Operative Neurosurgery

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BACKGROUND AND OBJECTIVE: Rapid design and production of patient-specific 3-dimensional–printed implants (3DPIs) present a novel opportunity to restore the biomechanically demanding integrity of the lumbopelvic junction. We present a unique case of a 61-year-old patient with severe neuropathic spinal arthropathy (Charcot spine) who initially underwent a T4-to-sacrum spinal fusion. Massive bone destruction led to dissociation of his upper body from his pelvis and legs. Reconstruction of the spinopelvic continuity was planned with the aid of a personalized lumbosacral 3DPI. METHOD: Using high-resolution computed tomography scans, the custom 3DPI was made using additive titanium manufacturing. The unique 3DPI consisted of (1) a sacral platform with iliac screws, (2) modular corpectomy device with rigid connection to the sacral platform, and (3) anterior plate connection with screws for proximal fixation. The procedures to obtain compassionate use Food and Drug Administration approval were followed. The patient underwent debridement of a chronically open wound before undertaking the 3-stage reconstructive procedure. The custom 3DPI and additional instrumentation were inserted as part of a salvage rebuilding procedure. RESULTS: The chronology of the rapid implementation of the personalized sacral 3DPI from decision, design, manufacturing, Food and Drug Administration approval, and surgical execution lasted 28 days. The prosthesis was positioned in the defect according to the expected anatomic planes and secured using a screw–rod system and a vascularized fibular bone strut graft. The prosthesis provided an ideal repair of the lumbosacral junction and pelvic ring by merging spinal pelvic fixation, posterior pelvic ring fixation, and anterior spinal column fixation. CONCLUSION: To the best of our knowledge, this is the first case of a multilevel lumbar, sacral, and sacropelvic neuropathic (Charcot) spine reconstruction using a 3DPI sacral prosthesis. As the prevalence of severe spine deformities continues to increase, adoption of 3DPIs is becoming more relevant to offer personalized treatment for complex deformities.

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“…In this case, the authors proposed a printing process for scaffolds using laser sintering technology (LS). This technology represents a versatile 3D printing mode based on the coalescence of powders from a sintering process that allows obtaining parts with resolutions higher than FFF [ 132 ]. In terms of hydrophobicity, the reinforced samples generated an increase in the hydrophilic character of the systems together with a higher degradability after 12 weeks of study due to the higher degradable speed of the reinforcement with respect to the polymeric matrix.…”

Section: Bioabsorbable Composite Materials Based On Polymeric Matrix ...mentioning

confidence: 99%

Bioabsorbable Composites Based on Polymeric Matrix (PLA and PCL) Reinforced with Magnesium (Mg) for Use in Bone Regeneration Therapy: Physicochemical Properties and Biological Evaluation

García-Sobrino,

Muñoz,

Rodríguez-Jara

et al. 2023

Polymers

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Improvements in Tissue Engineering and Regenerative Medicine (TERM)–type technologies have allowed the development of specific materials that, together with a better understanding of bone tissue structure, have provided new pathways to obtain biomaterials for bone tissue regeneration. In this manuscript, bioabsorbable materials are presented as emerging materials in tissue engineering therapies related to bone lesions because of their ability to degrade in physiological environments while the regeneration process is completed. This comprehensive review aims to explore the studies, published since its inception (2010s) to the present, on bioabsorbable composite materials based on PLA and PCL polymeric matrix reinforced with Mg, which is also bioabsorbable and has recognized osteoinductive capacity. The research collected in the literature reveals studies based on different manufacturing and dispersion processes of the reinforcement as well as the physicochemical analysis and corresponding biological evaluation to know the osteoinductive capacity of the proposed PLA/Mg and PCL/Mg composites. In short, this review shows the potential of these composite materials and serves as a guide for those interested in bioabsorbable materials applied in bone tissue engineering.

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3D printed biomedical devices and their applications: A review on state-of-the-art technologies, existing challenges, and future perspectives

Cited by 33 publications

References 104 publications

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Rapid Implementation of a 3-Dimensional–Printed Patient-Specific Titanium Sacrum Implant for Severe Neuropathic Spinal Arthropathy and Guide to Compassionate US Regulatory Approval

Bioabsorbable Composites Based on Polymeric Matrix (PLA and PCL) Reinforced with Magnesium (Mg) for Use in Bone Regeneration Therapy: Physicochemical Properties and Biological Evaluation

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