3D printable and injectable lactoferrin-loaded carboxymethyl cellulose-glycol chitosan hydrogels for tissue engineering applications

Janarthanan, Gopinathan; Tran, Hao Nguyen; Cha, Eunchong; Lee, Chibum; Das, Dipankar; Noh, Insup

doi:10.1016/j.msec.2020.111008

Cited by 60 publications

(38 citation statements)

References 86 publications

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“…There is no absolute limit on how many types of pollutants can be present in wastewater that has come from multiple industries or other household activities. However, to the best of the author’s knowledge, CMC-based materials have been mainly used thus far for the removal of various organic-inorganic dyes [ 74 , 199 , 200 , 201 ], inorganic ionic pollutants (both anions and cations) [ 202 , 203 , 204 , 205 ], as well as various radioactive species [ 83 , 206 , 207 , 208 ] from polluted waters in different experimental conditions.…”

Section: Application Of Cmcmentioning

confidence: 99%

“…Copyright 2021, Elsevier; ( e ) SEM images of the dried CMC-GC gels with different compositions. Reproduced with permission from [ 208 ]. Copyright 2021, Elsevier; ( f ) Photos of the neat PDMS and composite Na–CMC/PDMS filaments used in FDM; SEM images, at different magnification [ 233 ]; ( g , h ) the composite filament printed in layers.…”

Section: Figures and Schemementioning

confidence: 99%

“…The same year, Ji et al (2020) [235] presented two novel CMC-based macromers (modified with amide and ester cross-linker, respectively) as costefficient bio-inkers for printing differential 3D-architectures with increased complexity (Figure 5d). In another study, Janarthanan et al (2020) [208] synthesized three different types of CMC/glycol chitosan-based hydrogels via simple in situ-ionic interactions and gelling Schiff's base reaction (Figure 5e). The biocompatible hydrogels (biocompatibility was evaluated using MC3T3 mouse osteoblast cells) showed enhanced stability after their in vitro 3D printing.…”

Section: D Bioprinting Processmentioning

confidence: 99%

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Recent Developments of Carboxymethyl Cellulose

et al. 2021

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Carboxymethyl cellulose (CMC) is one of the most promising cellulose derivatives. Due to its characteristic surface properties, mechanical strength, tunable hydrophilicity, viscous properties, availability and abundance of raw materials, low-cost synthesis process, and likewise many contrasting aspects, it is now widely used in various advanced application fields, for example, food, paper, textile, and pharmaceutical industries, biomedical engineering, wastewater treatment, energy production, and storage energy production, and storage and so on. Many research articles have been reported on CMC, depending on their sources and application fields. Thus, a comprehensive and well-organized review is in great demand that can provide an up-to-date and in-depth review on CMC. Herein, this review aims to provide compact information of the synthesis to the advanced applications of this material in various fields. Finally, this article covers the insights of future CMC research that could guide researchers working in this prominent field.

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Section: Application Of Cmcmentioning

confidence: 99%

Section: Figures and Schemementioning

confidence: 99%

Section: D Bioprinting Processmentioning

confidence: 99%

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Recent Developments of Carboxymethyl Cellulose

et al. 2021

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“…In recent years, bioinks that undergo rapid crosslinking using dynamic covalent chemistry have emerged. [ 227–231 ] For example, HA‐hydrazide and HA‐aldehyde form a hydrogel, which is shear thinning and extrudable and particularly useful for printing ( Figure a,b). [ 232 ] Similarly, oxidized alginates crosslinked with semicarbazone or hydrazone bonds are bioprintable and viscoelastic without calcium ion crosslinking.…”

Section: Emerging Concepts In the Application Of Dccsmentioning

confidence: 99%

Designing Hydrogels for 3D Cell Culture Using Dynamic Covalent Crosslinking

Rizwan

Baker

Shoichet

2021

Adv Healthcare Materials

101

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Designing simple biomaterials to replicate the biochemical and mechanical properties of tissues is an ongoing challenge in tissue engineering. For several decades, new biomaterials have been engineered using cytocompatible chemical reactions and spontaneous ligations via click chemistries to generate scaffolds and water swollen polymer networks, known as hydrogels, with tunable properties. However, most of these materials are static in nature, providing only macroscopic tunability of the scaffold mechanics, and do not reflect the dynamic environment of natural extracellular microenvironment. For more complex applications such as organoids or co‐culture systems, there remain opportunities to investigate cells that locally remodel and change the physicochemical properties within the matrices. In this review, advanced biomaterials where dynamic covalent chemistry is used to produce stable 3D cell culture models and high‐resolution constructs for both in vitro and in vivo applications, are discussed. The implications of dynamic covalent chemistry on viscoelastic properties of in vitro models are summarized, case studies in 3D cell culture are critically analyzed, and opportunities to further improve the performance of biomaterials for 3D tissue engineering are discussed.

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“…Self‐healing hydrogels not only have functions such as direct injection into damaged tissues, and serve as drug carriers, but also gradually attract widespread attention as a bio‐ink for 3D printing of tissue‐like structures. [ 72 ] Hydrogels that can be used as bio‐inks include chitosan‐based hydrogels, [ 73 ] cellulose and pectin‐based hydrogels, [ 74 ] and so on. Through pure physical cross‐linking, a highly stretchable, transparent, anti‐fatigue, self‐adhesive and self‐healing hydrogel can be prepared.…”

Section: Common Types and Main Functions Of Injectable Hydrogelsmentioning

confidence: 99%

Injectable Nanocomposite Hydrogels for Cancer Therapy

Zong

Guo

et al. 2021

Macromolecular Bioscience

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Hydrogel is a kind of 3D polymer network with strong swelling ability in water and appropriate mechanical and biological properties, which make it feasible to maintain bioactive substances and has promising applications in the fields of biomaterials, soft machines, and artificial tissues. Unfortunately, traditional hydrogels prepared by chemical crosslinking have poor mechanical properties and limited functions, which limit their further application. In recent years, with the continuous development of nanoparticle research, more and more studies have combined nanoparticles with hydrogels to make up for the shortcomings of traditional hydrogels. In this article, the types and functions of hydrogels and nanomaterials are introduced first, as well as the functions and applications of injectable nanocomposite hydrogels (INHs), then the latest progress of INHs for cancer treatment is reviewed, some existing problems are summarized, and the application prospect of NHs is prospected.

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3D printable and injectable lactoferrin-loaded carboxymethyl cellulose-glycol chitosan hydrogels for tissue engineering applications

Cited by 60 publications

References 86 publications

Recent Developments of Carboxymethyl Cellulose

Recent Developments of Carboxymethyl Cellulose

Designing Hydrogels for 3D Cell Culture Using Dynamic Covalent Crosslinking

Injectable Nanocomposite Hydrogels for Cancer Therapy

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