3D nanointerface enhanced optical microfiber for real-time detection and sizing of single nanoparticles

Abstract

Graphical abstract

Optical Microfiber Coated with WS2‐Supported Gold Nanobipyramids: Ultrasensitive Detecting Prostate Cancer Extracellular Vesicles in Complex Human Samples

“…The main sensor detected a single EV in different background solutions that exhibited different variations in the transmission spectra of the main sensor. By observing the step‐wise height of wavelength shift, [ 44 ] the size of PC exosomes in pure PBS and serum solution was mainly distributed in the range of 60–100 nm. However, the main sensor could mainly detect single microvesicle with a size of more than 150 nm.…”

Ultrasensitive Detection and Cellular Photothermal Therapy via a Self‐Photothermal Modulation Biosensor

“…The rapid and accurate detection of analytes (nucleic acids, proteins, viruses) at small concentrations is crucial in applications ranging from clinical diagnostics to environmental sensor. [23] It may also enhance the PTT effect. However, evanescent field enhancement at locations other than the fiber surface may increase the noise signals caused by interfering molecules or temperature changes in the solution.…”

“…Interface design can enhance the evanescent field of microfibers, thereby improving the light–matter interaction with the target analytes, which inherently improves the sensitivity of the sensor. [ 23 ] It may also enhance the PTT effect. However, evanescent field enhancement at locations other than the fiber surface may increase the noise signals caused by interfering molecules or temperature changes in the solution.…”

“…[24] Several works have demonstrated that integrating optical microfibers with localized surface plasmon resonance (LSPR) structures helps in not only enhancing the evanescent field but also confine the enhanced light-matter interactions on the microfiber surface. [12,23,25,26] Nobel metals, as a group of typical plasmon materials, have attracted widespread attention. [27,28] However, their resonance typically occurs at visible wavelengths, while the operating wavelengths of microfiber transducers are within the communication window (1550 nm).…”

An optical nanofibre-enabled on-chip single-nanoparticle sensor

“…Recently, Chen et al reported a portable optical microfibre sensor functionalized by a plasmonic nanointerface for single-nanoparticle detection and sizing. 24 These optical MNF sensors represent an easy-to-perform platform. However, to isolate a single nanoparticle, the sample must be diluted so that on average less than one particle resides in the effective detection region.…”