3D multi-structural foot imaging using dual-modal photoacoustic and ultrasound imaging

Choi, Wonseok; Park, Eunyeong; Jeon, Seungwan; Cho, Seonghee; Ahn, Jae-Sung; Park, Byullee; Kim, Chulhong

doi:10.1117/12.2579012

Cited by 2 publications

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“…(29,30) Others have recently demonstrated the use of PA imaging to assess peripheral hemodynamic changes in humans. (31)(32)(33)(34)(35), and thus we were motivated to use photoacoustic imaging to visualize angiogenesis. This could help clinicians make early and better-informed decisions on whether a particular treatment regimen should be continued.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Mantri

Tsujimoto

Donovan

et al. 2021

Preprint

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Chronic wounds are a major health problem that cause the medical infrastructure billions of dollars every year. Chronic wounds are often difficult to heal and cause significant discomfort. Although wound specialists have numerous therapeutic modalities at their disposal, tools that could 3D-map wound bed physiology and guide therapy do not exist. Visual cues are the current standard but are limited to surface assessment; clinicians rely on experience to predict response to therapy. Photoacoustic (PA) ultrasound (US) is a non-invasive, hybrid imaging modality that can solve these major limitations. PA relies on the contrast generated by hemoglobin in blood which allows it to map local angiogenesis, tissue perfusion and oxygen saturation - all critical parameters for wound healing. This work evaluates the use of PA-US to monitor angiogenesis and stratify patients responding vs. not-responding to therapy. We imaged 19 patients with 22 wounds once a week for at least three weeks. Our findings suggest that PA imaging directly visualizes angiogenesis. Patients responding to therapy showed clear signs of angiogenesis and an increased rate of PA increase (p = 0.002). These responders had a significant and negative correlation between PA intensity and wound size. Hypertension was correlated to impaired angiogenesis in non-responsive patients. The rate of PA increase and hence the rate of angiogenesis was able to predict healing times within 30 days from the start of monitoring (power = 88%, alpha = 0.05) This early response detection system could help inform management and treatment strategies while improving outcomes and reducing costs.

show abstract

Section: Introductionmentioning

confidence: 99%

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Mantri

Tsujimoto

Donovan

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…PA imaging is ideally suited for this application due to centimetre-scale depth penetration and the contrast generated by haemoglobin in blood vessels. 29,30 Others have recently demonstrated the use of PA imaging to assess peripheral hemodynamic changes in humans, [31][32][33][34][35] and thus we were motivated to use PA imaging to visualise angiogenesis. We show here that the rate of PA signal increase directly reports the rate of angiogenesis.…”

mentioning

confidence: 99%

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Mantri

Tsujimoto

Donovan

et al. 2022

Wound Repair Regeneration

View full text Add to dashboard Cite

Chronic wounds are a major health problem that cause the medical infrastructure billions of dollars every year. Chronic wounds are often difficult to heal and cause significant discomfort. Although wound specialists have numerous therapeutic modalities at their disposal, tools that could three dimensional‐map wound bed physiology and guide therapy do not exist. Visual cues are the current standard but are limited to surface assessment; clinicians rely on experience to predict response to therapy. Photoacoustic (PA) ultrasound (US) is a non‐invasive, hybrid imaging modality that can solve these major limitations. PA relies on the contrast generated by haemoglobin in blood which allows it to map local angiogenesis, tissue perfusion and oxygen saturation—all critical parameters for wound healing. This work evaluates the use of PA‐US to monitor angiogenesis and stratify patients responding versus not‐responding to therapy. We imaged 19 patients with 22 wounds once a week for at least 3 weeks. Our findings suggest that PA imaging directly visualises angiogenesis. Patients responding to therapy showed clear signs of angiogenesis and an increased rate of PA increase (p = 0.002). These responders had a significant and negative correlation between PA intensity and wound size. Hypertension was correlated to impaired angiogenesis in non‐responsive patients. The rate of PA increase and hence the rate of angiogenesis was able to predict healing times within 30 days from the start of monitoring (power = 88%, alpha = 0.05). This early response detection system could help inform management and treatment strategies while improving outcomes and reducing costs.

show abstract

3D multi-structural foot imaging using dual-modal photoacoustic and ultrasound imaging

Cited by 2 publications

References 0 publications

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds

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