3D laser lithographic fabrication of hollow microneedle mimicking mosquitos and its characterisation

Suzuki, Masato; Takahashi, Tomokazu; Aoyagi, Shigeaki

doi:10.1504/ijnt.2018.089545

Cited by 48 publications

(27 citation statements)

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“…Step 5 [207] with permission from Inderscience analysis is performed prior to clinical practice to allow researchers to refine and improve upon the insertion process.…”

Section: Labrum Tissuementioning

confidence: 99%

“…In another study, by using 3D printing technology, Suzuki et al . tried to mimic the structure of a proboscis of a mosquito to achieve painless insertion of hollow needles in the skin [ 207 ]. The proboscis is composed of different parts (e.g., labrum and maxillae), which mosquitos are able to move separately to penetrate the stratum corneum (Fig.…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

“…Moreover, the capillary force generated inside the device was sufficient to draw enough blood to perform glucose analysis in few seconds. While this is not the first time that the proboscis architecture has been replicated by microfabrication techniques, the use of DLW allowed for an unprecedented 3D freedom during the fabrication process [ 207 ].

Fig.…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.

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“…Step 5 [207] with permission from Inderscience analysis is performed prior to clinical practice to allow researchers to refine and improve upon the insertion process.…”

Section: Labrum Tissuementioning

confidence: 99%

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

Fig.…”

Section: Strategies To Enhance Mn Insertionmentioning

confidence: 99%

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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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“…The mosquito fascicle, which is composed of six stylets, is approximately 70 µm in diameter, being far thinner than commercial medical needles of which diameter are usually over several hundred µm (Suzuki, 2008). One of the reasons why mosquito piercings are painless is the thinness of their fascicle, and the potential for fascicles to avoid pain receptors (free nerve endings) becomes higher as they become thinner.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of TRPV1 and TRPA1 by mosquito and mouse saliva

Derouiche

Sakai

et al. 2020

Preprint

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Keywords:mosquito | saliva | transient receptor potential ankyrin 1 (TRPA1) | transient receptor potential vanilloid 1 (TRPV1) AbstractArthropods are the largest group of living organisms and among them, mosquitoes spread parasites and viruses causing deathly diseases. Mosquito's painless piercing is due to the thinness of their fascicle, but mosquito saliva might also contribute to it. We found that mosquito and mouse saliva inhibit TRPV1 and TRPA1 channels, either heterologously expressed in HEK293T cells or endogenously expressed in native mouse sensory neurons.We have also identified sialorphin as a candidate antinociceptive peptide as it showed similar effects on TRPV1 and TRPA1. Finally, we confirmed the antinociceptive effects of saliva and sialorphin in vivo by observing decreased pain-related behaviors in mice coinjected with these substances. Similar inhibitory effects of mosquito and mouse saliva suggest that the antinociceptive effects of saliva are universal, which could explain why many animals including humans often lick their wounds. These findings would lead to the development of novel anti-nociceptive agents.

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“…1 MEMS devices produced with the 2PP method can be used as micro-fluids, 2 micro-mechanical systems, [3][4][5] optical systems, 6,7 cell structures, 8 and biomedical devices. 9,10 The PμSL method is also used by many companies today. The NanoArch™ is a 3D micro-fabrication equipment based on the PμSL technology.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of mems-based electrothermal microactuators with additive manufacturing technologies

Yüce¹,

Akkuş²,

Ertugrul³

2019

Mater. Tehnol.

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This study aimed to fabricate a bidirectional electrothermal microactuator that can be produced with the conventional micro-electromechanical system (MEMS) fabrication technique, using two-photon polymerization (2PP) and projection micro-stereolithography (PμSL) methods and to compare these methods with each other. The electrothermal microactuator that can move in two directions was designed in accordance with determined criteria. Although the same design was used for the 2PP and PμSL methods, the supporting structures were not produced with the PμSL method. For the PμSL method, the actuator was produced by removing the supports from the original design. Although 2-μm-diameter supports could be fabricated with the 2PP method, it was not possible to produce them with the PμSL method. Furthermore, the 2PP method was found to be better than the PμSL for the production of complex, non-symmetric support structures.

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3D laser lithographic fabrication of hollow microneedle mimicking mosquitos and its characterisation

Cited by 48 publications

References 0 publications

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Inhibition of TRPV1 and TRPA1 by mosquito and mouse saliva

Fabrication of mems-based electrothermal microactuators with additive manufacturing technologies

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