3D in-situ characterization reveals the instability-induced auxetic behavior of collagen scaffolds for tissue engineering
Enze Chen,
Byumsu Kim,
Nikolaos Bouklas
et al.
Abstract:Collagen scaffolds seeded with human chondrocytes have shown great potential for cartilage repair and regeneration. However, these porous scaffolds buckle under low compressive forces, creating regions of highly localized deformations that can cause cell death and deteriorate the integrity of the engineered tissue. We perform three-dimensional (3D) tomography-based characterization to track the evolution of collagen scaffolds’ microstructure under large deformation. The results illustrate how instabilities pro… Show more
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