2016
DOI: 10.1038/srep29936
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3D Imaging of Nanoparticle Distribution in Biological Tissue by Laser-Induced Breakdown Spectroscopy

Abstract: Nanomaterials represent a rapidly expanding area of research with huge potential for future medical applications. Nanotechnology indeed promises to revolutionize diagnostics, drug delivery, gene therapy, and many other areas of research. For any biological investigation involving nanomaterials, it is crucial to study the behavior of such nano-objects within tissues to evaluate both their efficacy and their toxicity. Here, we provide the first account of 3D label-free nanoparticle imaging at the entire-organ sc… Show more

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Cited by 93 publications
(58 citation statements)
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“…LipsImag can provide 3-dimensional elemental mapping for laser ablation depth [27,35,36,37,45]. As discussed above, the laser ablation depth of the maize leaf is approximately 12 µm with a 90 mJ laser and a 75 µm spot size.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…LipsImag can provide 3-dimensional elemental mapping for laser ablation depth [27,35,36,37,45]. As discussed above, the laser ablation depth of the maize leaf is approximately 12 µm with a 90 mJ laser and a 75 µm spot size.…”
Section: Resultsmentioning
confidence: 99%
“…LIBS has been used to qualitatively and quantitatively measure solids, liquids, and gases based on atomic, ionic, and molecular spectral characteristics [28,29,30,31]. LIBS has also been used for fast mapping and imaging elemental distributions on solid surfaces [27,32,33,34,35,36,37,38,39]. Compared with other imaging and mapping methods, LIBS is advantageous due to its simple structure, flexibility in use, and low cost, and it can be used in-field, is removable, and can even be used as a handheld device [28,40].…”
Section: Introductionmentioning
confidence: 99%
“…However, to quantify volume changes and verify the complete fracturing of a particle into multiple pieces, one must know 3D imaging with high precision 201, 202. X‐ray crystallography as the primary method has been utilized to solve the 3D atomic structure of crystals in the last century 203.…”
Section: Atomic‐scale Studies Of the Storage Mechanisms Of Anode Nanomentioning
confidence: 99%
“…[45][46][47] In the current study, LIBS coupled with an automated sample chamber was evaluated for spatial prediction of Na and K contents in minced beef sample pellets in order to study the elemental distribution within a sample, as well as an indication of homogeneity and therefore accuracy in the calibration models.…”
Section: Spatial Mappingmentioning
confidence: 99%