3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties

Racette, Molly; saleh, Habib Al; Waller, Kenneth R.; Bleedorn, Jason A.; McCabe, Ronald P.; Vanderby, Ray; Markel, Mark D.; Brounts, Sabrina H.; Block, Walter F.; Muir, Peter

doi:10.1016/j.tvjl.2015.10.055

Cited by 9 publications

(18 citation statements)

References 24 publications

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“…In normal dogs ex vivo , estimation of CrCL ligament volume using MR imaging correlates with ligament structural properties, including yield load and load to failure [20]. In the present study, normalized CrCL ligament volume, estimated using both FSE Cube and VIPR-aTR sequences, did not correlate with synovitis or CrCL fiber damage in the partial CR stifle.…”

Section: Discussioncontrasting

confidence: 55%

Radiographic and magnetic resonance imaging predicts severity of cruciate ligament fiber damage and synovitis in dogs with cranial cruciate ligament rupture

et al. 2017

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Cruciate ligament rupture (CR) and associated osteoarthritis (OA) is a common condition in dogs. Dogs frequently develop a second contralateral CR. This study tested the hypothesis that the degree of stifle synovitis and cranial cruciate ligament (CrCL) matrix damage in dogs with CR is correlated with non-invasive diagnostic tests, including magnetic resonance (MR) imaging. We conducted a prospective cohort study of 29 client-owned dogs with an unstable stifle due to complete CR and stable contralateral stifle with partial CR. We evaluated correlation of stifle synovitis and CrCL fiber damage with diagnostic tests including bilateral stifle radiographs, 3.0 Tesla MR imaging, and bilateral stifle arthroscopy. Histologic grading and immunohistochemical staining for CD3+ T lymphocytes, TRAP+ activated macrophages and Factor VIII+ blood vessels in bilateral stifle synovial biopsies were also performed. Serum and synovial fluid concentrations of C-reactive protein (CRP) and carboxy-terminal telopeptide of type I collagen (ICTP), and synovial total nucleated cell count were determined. Synovitis was increased in complete CR stifles relative to partial CR stifles (P<0.0001), although total nucleated cell count in synovial fluid was increased in partial CR stifles (P<0.01). In partial CR stifles, we found that 3D Fast Spin Echo Cube CrCL signal intensity was correlated with histologic synovitis (SR = 0.50, P<0.01) and that radiographic OA was correlated with CrCL fiber damage assessed arthroscopically (SR = 0.61, P<0.001). Taken together, results of this study show that clinical diagnostic tests predict severity of stifle synovitis and cruciate ligament matrix damage in stable partial CR stifles. These data support use of client-owned dogs with unilateral complete CR and contralateral partial CR as a clinical trial model for investigation of disease-modifying therapy for partial CR.

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Section: Discussioncontrasting

confidence: 55%

Radiographic and magnetic resonance imaging predicts severity of cruciate ligament fiber damage and synovitis in dogs with cranial cruciate ligament rupture

et al. 2017

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“…Similarly, mechanical testing of the stifle joint was not possible in our clinically recruited patients. From the clinical standpoint, orthopedic assessment was used to assess stifle joint stability …”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance imaging is the preferred method for the diagnosis of anterior cruciate ligament tears in people . It offers improved soft tissue contrast and detail compared to computed tomography.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of 3 Tesla magnetic resonance imaging using detection of fiber loss and a visual analog scale for diagnosing partial and complete cranial cruciate ligament ruptures in dogs

Fazio

Muir

Schaefer

et al. 2017

Vet Radiology Ultrasound

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Canine cranial cruciate ligament rupture is often bilateral and asymmetrical, ranging from partial to complete rupture. The purpose of our diagnostic accuracy study was to assess the accuracy of 3 Tesla magnetic resonance imaging (MRI) detection of fiber loss and use of a visual analog scale in the diagnosis of complete versus partial cranial cruciate ligament rupture in 28 clinical dogs with unilateral complete rupture and contralateral partial rupture. Three Tesla MRI was performed on 56 stifles using sagittal sequences (T2-weighted fast spin echo with fat saturation, proton density fast spin echo, and T2-weighted 3D fast spin echo CUBE). Two MRI observers assessed the cranial cruciate ligament for fiber loss and completed a visual analog scale. The MRI data were compared to arthroscopy and clinical status. Accuracy classifying partial or complete rupture was assessed using receiver operating characteristic analysis. Compared to arthroscopy, for complete cranial cruciate ligament rupture, sensitivity, specificity, and accuracy of MRI detection of fiber loss were 0.78, 0.50-0.60, and 0.68-0.71, respectively, and, for partial tears, specificity was 1.00. An MRI In stifles with clinically unstable complete cranial cruciate ligament rupture, both MRI tests are sensitive though not specific compared to arthroscopy. As a diagnostic imaging method, MRI may help guide treatment in patients with cranial cruciate ligament damage, particularly for stable partial rupture.

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“…Arthroscopic stifle examination is the current gold standard for the identification of CrCL and CaCL fibre damage, as it provides a direct magnified view of the surface of the ligaments and enables ligament probing to assess rupture of fibre bundles . Ultrasound and magnetic resonance (MR) imaging can also be used to examine the cruciate ligaments and assess fibre damage. These imaging methods enable the examination of the entire volume of the ligament and not just surface features.…”

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confidence: 99%

“…In a recent study, ultrasonography had a low sensitivity of 50% in the diagnosis of CR . MR imaging using a 3 Tesla scanner with a 3D FSE CUBE sequence can provide excellent images of the cruciate ligaments, menisci, articular cartilage and soft tissue structures of the stifle, but availability for clinical imaging is limited.…”

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Correlation between orthopaedic and radiographic examination findings and arthroscopic ligament fibre damage in dogs with cruciate ligament rupture

2019

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Objective The objective is to study the correlations between physical examination and stifle radiography findings and severity of arthroscopic cranial cruciate ligament (CrCL) fibre damage in dogs with cruciate rupture (CR).Design Design Prospective clinical study.Methods Twenty-nine client-owned dogs with CR underwent physical examination, stifle radiography and arthroscopy, and the findings were recorded. Initial examination was repeated after sedation and after general anaesthesia. The Spearman rank correlations of examination variables with diagnostic imaging were examined.Results Overall, cranial tibial translation assessed by the tibial compression test in extension showed correlation with arthroscopic CrCL fibre damage (P < 0.05). Correlations between severity of cranial drawer laxity and arthroscopic CrCL fibre damage were not significant. Under general anaesthesia, stifle laxity tests were positively correlated with lameness severity grade (S R ≥ 0.41, P < 0.05). Meniscal damage was correlated with pain on the internal rotation of the tibia (S R = 0.42, P < 0.05) and severity of radiographic osteophytosis (S R = 0.53, P = 0.01).Conclusion Detection and estimation of severity of cranial tibial translation enable the diagnosis of CR and also the inference of the severity of CrCL fibre rupture, particularly with the tibial compression test in extension. Severity of joint laxity is best assessed under general anaesthesia. Such knowledge should reduce the risk of misdiagnosis and may enhance early diagnosis and treatment of dogs with CR over time.

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3D FSE Cube and VIPR-aTR 3.0 Tesla magnetic resonance imaging predicts canine cranial cruciate ligament structural properties

Cited by 9 publications

References 24 publications

Radiographic and magnetic resonance imaging predicts severity of cruciate ligament fiber damage and synovitis in dogs with cranial cruciate ligament rupture

Radiographic and magnetic resonance imaging predicts severity of cruciate ligament fiber damage and synovitis in dogs with cranial cruciate ligament rupture

Accuracy of 3 Tesla magnetic resonance imaging using detection of fiber loss and a visual analog scale for diagnosing partial and complete cranial cruciate ligament ruptures in dogs

Correlation between orthopaedic and radiographic examination findings and arthroscopic ligament fibre damage in dogs with cruciate ligament rupture

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