3D finite element model of the chinchilla ear for characterizing middle ear functions

Wang, Xuelin; Gan, Rong Z.

doi:10.1007/s10237-016-0758-5

Cited by 25 publications

(23 citation statements)

References 42 publications

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“…More than this, in case of minipig (HaiJin et al, ), a synovial joint is described in case of the maleo‐incal joint, contrary to the one in humans (Isaacson, ) that remains a cartilaginous one throughout the entire life. The metrical data we obtained are about 10% lower than the data provided by other authors (Vrettakos et al, ; Wang & Gan, ) in chinchilla for the rotational axis of the maleo‐incal complex.…”

Section: Discussioncontrasting

confidence: 82%

“…Contrary to this state, the neck of the malleus is almost indistinguishable in chinchilla as in pig, rat and mouse (Hoffstetter et al, ; Mohammadpour, ) where this sector is quite elongated and clearly defined. For the measurement of the lever arm of the malleus, we note again a 10%–13% lower value than the ones published earlier (Vrettakos et al, ; Wang & Gan, ).…”

Section: Discussioncontrasting

confidence: 65%

“…The “free mobility” (Vrettakos et al, ; Whyte et al, ) and “microtype” apparatus and one axis of rotation of the ossicular assembly make chinchillas a suitable candidate for animal model ear surgery (Bergin et al, ) or audiometric studies (Dong, Varavva, & Olson, ; Lavender, Taraskin, & Mason, ). The general anatomy of the ear in rodents is described both by classical anatomy books (Dyce, Sack, & Wensig, ) and by detailed scientific papers (Li et al, ; Vrettakos et al, ; Wang & Gan, ). Unfortunately, it seems that the detailed description of the chinchilla model is still missing series of data, both functionally and morphologically.…”

Section: Discussionmentioning

confidence: 99%

“…Measurements on the auditory ossicles were made in accordance with the data suggested by a series of authors (Gürbüz et al, ; Kurtul et al, ; Vrettakos et al, ; Wang & Gan, ), combining these data sets for each of the measured ossicles.…”

Section: Methodsmentioning

confidence: 99%

“…Data related to the detailed anatomy of the auditory ossicles are relatively limited. A few elements were reported in case of birds (Mills, ), different rodents (Kerber & Sánchez‐Villagra, ; Kurtul et al, ; Lee, Park, Kang, & Choung, ; Li, Gao, Ding, & Salvi, ; Maier, Tröscher, & Ruf, ; Martins et al, ; Mohammadpour, , ; Şanlı, Sedat, & Oztürk, ), humans (García‐Real, Kass, Sturges, & Wisner, ; Isaacson, ), swine (Gurr, Kevenhörster, Stark, Pearson, & Dazert, ; Hoffstetter et al, ; Pracy, White, Mustafa, Smith, & Perry, ), miniature pigs (HaiJin et al, ), sheep (Ayres Seibel, Lavinsky, & Preto De Oliveira, ; Simaei, Soltanalinejad, Najafi, & Shalizar Jalali, ), chinchilla (Vrettakos, Dear, & Saunders, ; Wang & Gan, ), cat (Beck, Kilchling, & Meyer‐Lindenberg, ; Seifert et al, ), dog (Berghes, Parvu, Cucoanes, & Cuca, ) and wolf (Gürbüz et al, ), badger (Rozen‐Rechels, Peigné, Germain, & Ladevèze, ), horse (Blanke, Aupperle, Seeger, Kubick, & Schusser, ), donkey (Awal et al, ), common degu (32) or other subterranean cavimorphes (Argyle & Mason, ).…”

Section: Introductionmentioning

confidence: 99%

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Morphological and morphometrical study of the auditory ossicles in chinchilla

Martonos

Damian

Gudea

et al. 2019

Anat Histol Embryol

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| INTRODUC TI ONThe ear (organum vestibulocochleare) is a complex sense organ that shelters a series of anatomical entities involved in the hearing process and balance. Anatomically, the ear consists of three distinctive sectors: the external ear (auris externa), the middle ear (auris media) and the internal ear (auris interna). Placed in the dorsal part of the tympanic cavity (cavum tympany), within the temporal bone, the petrosal part (os temporale, pars petrosa), the assembly of the auditory ossicles (ossicula auditus) plays an important role in the sound transmission from the tympanic membrane (membrana tympany) to the internal ear (vestibular fenestra-fenestra vestibule) ( AbstractThis study is meant to illustrate and describe the features of the auditory ossicles of the chinchilla (Chinchilla lanigera), one of the species used more and more frequently in otology and ear surgery as animal model. Cephalic extremities of 12 C. lanigera individuals obtained from a private farm, where this species was bred for fur, were used in this study. The ossicles were obtained either by direct surgical harvesting by mastoid approach or after a dermestid beetle exposure followed by anatomical dissection. The three ossicles that form the assembly are the malleus, incus and stapes.After the removal of these ossicles, a series of anatomical descriptions were made, followed by seriate sets of measurements. The malleus and incus form a joined-single unit called the maleo-incal complex, with an elongated straight appearance, also due to the development of the anterior process. The handle of the malleus and the long process of incus are almost perpendicular to the main axis of the maleo-incal complex. The presence of the muscular process on the handle of the malleus is recorded.The overall shape of the incus is given by the uneven development of the two processes and the reduced neck part. The stapes is the smallest of the components that maintains the well-known architecture in accordance with the general model. The morphology of all three ossicles is backed by a series of measurements, some standard, some adapted to the morphology of the ossicles. From the very reduced comparative metrical data at our disposal, our study presents an average of 10% lower values for the ones presented earlier by other researchers in the same species. K E Y W O R D Sanatomy, auditory ossicles, chinchilla, middle ear, morphometry | 341 MARTONOS eT Al.

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Section: Discussioncontrasting

confidence: 82%

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Morphological and morphometrical study of the auditory ossicles in chinchilla

Martonos

Damian

Gudea

et al. 2019

Anat Histol Embryol

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Surface Motion of Tympanic Membrane in a Chinchilla Model of Acute Otitis Media

Wang

Gan

2018

JARO

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The conductive hearing loss caused by acute otitis media (AOM) is commonly related to a reduction of the tympanic membrane (TM) mobility in response to sound stimuli. However, spatial alterations of the TM surface motion associated with AOM have rarely been addressed. In this study, the TM surface motion was determined using scanning laser Doppler vibrometry (SLDV) in a chinchilla model of AOM. The AOM was established by transbullar injection of nontypeable Haemophilus influenzae. The TM surface vibration was measured in control (uninfected) animals and two AOM groups of animals: 4 days (4D) and 8 days (8D) post inoculation. To quantify the effect of middle ear pressure in those infected ears, the SLDV measurement was first conducted in unopened AOM ears and then in middle ear pressure released ears. Results showed that middle ear infection generally reduced the TM displacement across the entire surface, but the reduction in the umbo displacement over the time course, from 4 to 8 days post inoculation, was less than the reduction in the displacement at the center of each quadrant. The presence of middle ear fluid shifted the occurrence of traveling-wave-like motion on the TM surface to lower frequencies. The observation of the spatial variations of TM surface motion from this study will help refine our understanding of the middle ear sound transmission characteristics in relation to AOM.

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