3D fiber-deposited scaffolds for tissue engineering: Influence of pores geometry and architecture on dynamic mechanical properties

Moroni, Lorenzo; Wijn, J.R. de; Blitterswijk, Clemens A. van

doi:10.1016/j.biomaterials.2005.07.023

Cited by 458 publications

(357 citation statements)

References 43 publications

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“…Different types of polymer fibers can affect the rate of material degradation, loading and release of biomolecules, and material mechanical properties. 5,6 The flexibility in material selection allows for engineering scaffolds that can match specific tissue material properties and regeneration dynamics. 7,8 Polymer fibers may be synthesized by micro and submicron size extrusion, melt-blowing, force-spinning, flashspinning or coaxial spinneret electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Airbrushed Composite Polymer Zr-ACP Nanofiber Scaffolds with Improved Cell Penetration for Bone Tissue Regeneration

Hoffman

Škrtić²,

Sun³

et al. 2015

Tissue Engineering Part C: Methods

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Electrospun polymer nanofibers have multiple applications in the tissue engineering field despite limited cell penetration within the scaffolds and slow synthesis rates. Airbrushing, a proposed alternative to traditional electrospinning, is a technique capable of synthesizing open structure nanofiber scaffolds at high rates. In this study, three biocompatible polymers-poly-D,L-lactic acid (P-DL-LA), polycaprolactone (PCL), and poly (methyl methacrylate) (PMMA), were airbrushed to form networks for bone tissue regeneration. All three polymers were loaded with up to 20% (w/w) zirconium-modified amorphous calcium phosphate (Zr-ACP). A simple one-step mix and straightforward material deposition yielded open structure networks with welldistributed Zr-ACP. Cell penetration within the airbrushed scaffolds was found to be more than twice the cell penetration within conventional electrospun networks. The airbrushed polymer network supported cell growth and differentiation. Cells grown on the Zr-ACP in P-DL-LA fibers exhibited improved levels of osteocalcin protein with an increase in the Zr-ACP content by day 16. This airbrushing method promises to be a viable and attractive alternative to currently used electrospinning techniques in the formation of composite 3D nanofiber scaffolds for tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Airbrushed Composite Polymer Zr-ACP Nanofiber Scaffolds with Improved Cell Penetration for Bone Tissue Regeneration

Hoffman

Škrtić²,

Sun³

et al. 2015

Tissue Engineering Part C: Methods

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show abstract

“…Works have also been done on DMA of polymers. Moroni et al (2006) have carried out DMA on 3D fibredeposited scaffolds and investigated the influence of pore geometry and architecture on dynamic mechanical properties. Más et al (2002) investigated dynamic mechanical properties of Polycarbonate (PC) and ABS blends and compared the results with other techniques like dielectric and calorimetric analysis.…”

Section: Ajeasmentioning

confidence: 99%

Study of Dynamic Mechanical Properties of Fused Deposition Modelling Processed Ultem Material

Arivazhagan¹,

Saleem²,

Masood³

et al. 2014

American Journal of Engineering and Applied Sciences

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Fused Deposition Modelling (FDM), a renowned Rapid Prototyping (RP) process, has been successfully implemented in several industries to fabricate concept models and prototypes for rapid manufacturing. This study furnishes terse notes about the material damping properties of FDM made ULTEM samples considering the effect of FDM process parameters. Dynamic Mechanical Analysis (DMA) is carried out using DMA 2980 equipment to study the dynamic response of the FDM material subjected to single cantilever loading under periodic stress. Three FDM process parameters namely Build Style, Raster Width and Raster Angle were contemplated. ULTEM parts are fabricated using solid normal build style and three values each of raster width and raster angle. DMA is performed with temperature sweep at three different fixed frequencies of 1, 50 and 100 Hz. Results were obtained for dynamic properties such as Maximum Storage Modulus, Maximum Loss Modulus, Maximum Tan Delta and Maximum Complex Viscosity. The present work discusses the effect of increasing the frequencies and temperature on FDM made ULTEM samples using different FDM process parameters.

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“…2a). It is reported that this configuration is potentially the most effective in mimicking the biomechanical behavior of bovine cartilage [19]. The strands within each layer were laid with an offset with respect to the previous layers in order to form a staggered pattern (Fig.…”

Section: Scaffold Fabricationmentioning

confidence: 99%

“…Therefore, the emerging solid free-form fabrication (SFF) techniques are becoming the method of choice for tissue engineering applications. Among these processes, the 3D-plotting technique has shown a great potential in producing reproducible 3D scaffolds featuring interconnected pores and controlled architecture [19]. In contrast to conventional rapid prototyping systems, which are mainly focused on fused deposition, the 3D-plotting technique can be applied to a much larger variety of synthetic and natural materials, including aqueous solutions and pastes [20].…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

Yousefi¹,

Gauvin²,

Sun³

et al. 2007

Polymer Engineering & Sci

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Regenerating the load‐bearing tissues requires 3D scaffolds that balance the temporary mechanical function with the biological requirements. In functional tissue engineering, designing scaffolds with biomimetic mechanical properties could promote tissue ingrowth since the cells are sensitive to their local mechanical environment. This work aims to design scaffolds that mimic the mechanical response of the biological tissues under physiological loading conditions. Poly(L‐lactide) (PLLA) scaffolds with varying porosities and pore sizes were made by the 3D‐plotting technique. The scaffolds were tested under unconfined ramp compression to compare their stress profile under load with that of bovine cartilage. A comparison between the material parameters estimated for the scaffolds and for the bovine cartilage based on the biphasic theory enabled the definition of an optimum window for the porosity and pore size of these constructs. Moreover, the finite element prediction for the stress distribution inside the scaffolds, surrounded by the host cartilaginous tissue, demonstrated a negligible perturbation of the stress field at the site of implantation. The finite element modeling tools in combination with the developed methodology for optimal porosity/pore size determination can be used to improve the design of biomimetic scaffolds. POLYM. ENG. SCI., 47:608–618, 2007. © 2007 Society of Plastics Engineers.

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3D fiber-deposited scaffolds for tissue engineering: Influence of pores geometry and architecture on dynamic mechanical properties

Cited by 458 publications

References 43 publications

Airbrushed Composite Polymer Zr-ACP Nanofiber Scaffolds with Improved Cell Penetration for Bone Tissue Regeneration

Airbrushed Composite Polymer Zr-ACP Nanofiber Scaffolds with Improved Cell Penetration for Bone Tissue Regeneration

Study of Dynamic Mechanical Properties of Fused Deposition Modelling Processed Ultem Material

Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

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