3D ECG- and respiratory-gated non-contrast-enhanced (CE) perfusion MRI for postoperative lung function prediction in non-small-cell lung cancer patients: A comparison with thin-section quantitative computed tomography, dynamic CE-perfusion MRI, and perfus

Abstract

Non-CE-perfusion MRI may be able to predict postoperative lung function more accurately than qualitatively assessed MDCT and perfusion scan.

Predicting Postoperative Lung Function Following Lung Cancer Resection: A Systematic Review and Meta-analysis

“…The tests broadly involve estimation of how much lung tissue is to be removed with or without estimation of the functionality of the lung. CT volume tests used the volume of the lobe to be resected as measured on CT relative to the total lung volumes as the proportion of function expected to be lost [13]. CT-VD tests take into account the density of lung tissue in Hounsfield units, a measure of emphysematous destruction, in addition to lung volumes to define functional lung tissue [13], [14], [15], [16], [17].…”

“…CT volume tests used the volume of the lobe to be resected as measured on CT relative to the total lung volumes as the proportion of function expected to be lost [13]. CT-VD tests take into account the density of lung tissue in Hounsfield units, a measure of emphysematous destruction, in addition to lung volumes to define functional lung tissue [13], [14], [15], [16], [17]. CT density masks to define functional lung tissue varied between − 1024 and − 910 for the lower limit − 650 and − 500 for the upper limit [13], [14], [15], [16].…”

“…CT-VD tests take into account the density of lung tissue in Hounsfield units, a measure of emphysematous destruction, in addition to lung volumes to define functional lung tissue [13], [14], [15], [16], [17]. CT density masks to define functional lung tissue varied between − 1024 and − 910 for the lower limit − 650 and − 500 for the upper limit [13], [14], [15], [16]. CT volumetry and partial densitometry used the volume of lung tissue but only defined a lower limit of Hounsfield units below which the tissue was considered emphysematous; an upper limit was not defined [18].…”

“…Three studies of FEV 1 prediction could not be meta-analysed but did describe comparisons of the accuracy different prediction techniques (Appendix 4). Yabuuchi et al reported change in FEV 1 rather than absolute values, they found CT-VD to outperform subsegment counting and CT volumetry [13]. Ohno et al 2015 reported FEV 1 percent of expected values rather than absolute values; they reported CT-VD and perfusion MRI (with and without contrast) to be comparable to each other but superior to both segment counting and perfusion scintigraphy [14].…”

Comparison of predicted postoperative forced expiratory volume in the first second (FEV1) using lung perfusion scintigraphy with observed forced expiratory volume in the first second (FEV1) post lung resection

“…[ 12 ] The dynamic perfusion MRI has shown good predictive capability, but it is expensive, technically difficult, and affected by motion and severe susceptibility artefacts. [ 13 ] Radionuclide perfusion scintigraphy is easily available, cost-effective, can noninvasively evaluate the regional lung function and is the most commonly used method to predict postoperative FEV1. [ 7 ] Many studies have shown good correlation between the actual postoperative FEV1 and PPO FEV1 obtained by lung perfusion scintigraphy.…”